Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

Products for Neuroscience

Cat.No. 产品名称 Information
GC91449 Ipamorelin (acetate)

Aib-His-D-2-Nal-D-Phe-Lys-NH₂; NNC 26-0161
Ipamorelin是一种五肽生长激素分泌素（GHS）和GHS受体1a（GHS-R1a）激动剂。
GC43906 Iperoxo (iodide) An agonist of muscarinic acetylcholine receptors
GC49299 Ipidacrine

伊匹达克林
An AChE inhibitor
GC12717 Ipratropium Bromide

异丙托溴铵; Sch 1000
A muscarinic receptor antagonist
GC68326 Ipratropium-d3 bromide

Sch 1000-d3
Ipratropium-d3 bromide (Sch 1000-d3) 是 Ipratropium bromide 的氘代物。Ipratropium bromide (Sch 1000) 是毒蕈碱的受体 (muscarinic receptor) 的拮抗剂，对 M1、M2 和 M3 受体的结合的 IC50 值分别为 2.9 nM、2 nM 和 1.7 nM。Ipratropium bromide 可用于 COPD 和哮喘等研究。
GC60938 Iprindole

伊普吲哚
Iprindole具有抗抑郁的生物活性，是一种弱的去甲肾上腺素和5-HT摄取的抑制剂。
GC60939 Iproniazid

异丙烟肼
Iproniazid (Marsilid, Iprazid) is a non-selective, irreversible monoamine oxidase (MAO) inhibitor (MAOI) that is used as an antidepressive agent.
GC33677 Iproniazid phosphate

磷酸异丙烟肼
Iproniazid (Marsilid, Iprazid) phosphate is a non-selective, irreversible monoamine oxidase (MAO) inhibitor (MAOI) that is used as an antidepressive agent.
GC13133 Ipsapirone

依普西隆,TVX Q 7821 free base
A partial agonist of serotonin 5-HT_1A receptors
GC91417 Ipsapirone (hydrochloride)

TVXQ 7821
伊普沙匹隆是一种5-羟色胺（5-HT）受体5-HT1A的部分激动剂（在海马膜中Ki = 10 nM）。它可以减少大鼠腹侧海马体内的5-HT释放。
GC63928 Iptakalim hydrochloride Iptakalim hydrochloride 是亲脂性的对氨基化合物，是 ATP 敏感的钾通道 (KATP) 的开放剂，也是包含α4β2 的烟碱乙酰胆碱受体 (nAChR)拮抗剂。
GC69290 Irdabisant

CEP-26401
Irdabisant (CEP-26401) 是一种具有选择性、口服活性和血脑屏障渗透性的组胺 H3 受体 (histamine H3 receptor, H3R) 拮抗剂/逆激动剂，对大鼠 H3R 和人 H3R 的 Ki 分别为 7.2 nM 和 2.0 nM。Irdabisant 对 hERG 电流的抑制活性相对较低，IC50 为 13.8 μM。Irdabisant 在大鼠社会认知模型中具有认知增强和唤醒作用。Irdabisant 可用于精神分裂症或认知障碍的研究。
GC31014 Irindalone (Lu 21-098)

茚达酮,Lu 21-?098
Irindalone (Lu 21-098) 是一种新型血清素 5-HT2 拮抗剂。
GC49493 IRL 1620 (trifluoroacetate salt)

PMZ-1620, SPI 1620, Suc-Glu9, Ala11,15-ET-1(8-21)
A peptide ET_B receptor agonist
GC13191 Irsogladine

伊索拉定; Dicloguamine
A gastroprotective agent
GC33878 Irsogladine maleate (Dicloguamine maleate)

马来酸伊索拉定; Dicloguamine maleate; MN1695
A gastroprotective agent
GC11984 Isamoltane hemifumarate Isamoltane hemifumarate 是 5-HT1B 受体的选择性拮抗剂，抑制 [125I]ICYP 与大鼠脑膜中 5-HT1B 识别位点的结合，IC50 为 39 nM。
GC12962 Isatin

靛红,Indoline-2,3-dione
Isatin (Indoline-2,3-dione) 是一种有效的单胺氧化酶 (MAO) 抑制剂，IC50 为 3 μM。
GC31104 Isocarboxazid

异卡波肼
An inhibitor of MAO
GN10186 Isocorynoxeine

异去氢钩藤碱; 7-Isocorynoxeine
An alkaloid with diverse biological activities
GC36334 Isoeugenol acetate

乙酸异丁香酚酯; Acetyl isoeugenol
Isoeugenol acetate 是一种肉豆蔻，丁香和肉桂的精油成分，对某些代谢酶如乙酰胆碱酯酶 (AChE) 酶 (IC50=77 nM; Ki=16 nM)，α-糖苷酶 (IC50=19.25 nM; Ki=21 nM) 和 α-淀粉酶 (IC50=411.5 nM) 具有良好的抑制作用。 Isoeugenol acetate 用于医疗和化妆品工业，具有抗氧化，抗癌，抗菌和抗炎特性。
GC45487 Isoflurane

异氟醚
Isoflurane是一种广泛应用的吸入麻醉药，具有强效麻醉、起效迅速和清除快的特点。
GC39134 Isofraxidin

异嗪皮啶
Isofraxidin (6,8-Dimethoxyumbelliferone), a bioactive coumarin compound isolated from the functional foods Siberian ginseng and Apium graveolens, is an anti-bacterial, anti-oxidant, and anti-inflammatory agent.
GC13567 Isoguvacine hydrochloride

异四氢烟酸
A GABA_A receptor agonist
GN10352 Isoimperatorin

异欧前胡素
A furanocoumarin that inhibits CYP1A
GC52027 Isolariciresinol

异落叶松脂素,(+)-Cyclolariciresinol
A lignan with diverse biological activities
GC36336 Isomerazin

异橙皮内酯
A coumarin with antioxidant and anti-inflammatory activities
GC25531 Isonipecotic acid

4-Piperidinecarboxylic acid, 4-Carboxypiperidine, Hexahydroisonicotinic acid
Isonipecotic acid (4-Piperidinecarboxylic acid, 4-Carboxypiperidine, Hexahydroisonicotinic acid) is a heterocyclic compound that mainly acts as a GABAA receptor partial agonist.
GC49306 Isopimaric Acid

异海松酸
A diterpenoid resin acid
GC49600 Isopropyl 5-(Diphenylphosphoryl)pentanoate

DPP isopropyl ester
A potential impurity in latanoprost preparations
GC39076 Isopteropodine

钩藤碱 E
Isopteropodine 是从 Uncaria tomentosa 分离得到的一种异育亨宾型辛吲哚生物碱，是 M1 型毒蕈碱乙酰胆碱 (muscarinic M1) 受体及 5-HT2 受体的正向调节剂。
GC48554 Isoreserpiline

3-Isoreserpilinic Acid, methyl ester, Neoreserpiline
An indole alkaloid with diverse biological activities
GC36340 Isorosmanol

异迷迭香酚
Isorosmanol 是从鼠尾草叶中分离出的一种松香烷型二萜，具有抗氧化、神经保护和神经营养作用。Isorosmanol 能抑制 AChE 活性和黑色素的合成。
GC48752 Isothipendyl (hydrochloride)

盐酸异西喷他
An antihistamine
GC39534 Isoxicam

伊索昔康
Isoxicam 是一种口服有效的非甾体抗炎剂，可用于关节炎的研究。Isoxicam 是一种非选择性的 COX-1 和 COX-2 抑制剂。
GC47471 Isoxsuprine-d6 (hydrochloride)

异舒普林盐酸盐 d6 (盐酸盐)
A neuropeptide with diverse biological activities
GC63548 Ispronicline

(2S,4E)-5-(5-异丙基吡啶-3-)-N-甲基戊-4-烯-2-胺,TC-1734; ACD3480
Ispronicline (TC-1734) 是一种有效的，具有口服活性的大脑选择性的 α4β2 nAChR 部分激动剂，具有增强记忆的特性和良好的耐受性。Ispronicline 高亲和力与 α4β2 nAChR 结合，Ki= 11 nM。
GC15895 Itopride hydrochloride

盐酸伊托必利; HSR803
An AChE inhibitor and a prokinetic agent
GC17575 Ivermectin B1a-d2 Deuterated ivermectin B1a
GC52403 Ivermectin-d2

22,23-dihydro Avermectin B1-d2
An internal standard for the quantification of ivermectin
GC12056 J 104129 fumarate M3 muscarinic receptor antagonist
GC10988 J 147 J 147 是一种非常有效的口服活性神经保护剂，用于增强认知能力。
GC41645 Jacaric Acid

8(Z),10(E),12(Z)-Octadecatrienoic Acid
A conjugated PUFA
GN10645 Jaceosidin

棕矢车菊素
A natural methylated trihydroxyflavone
GC91148 JAK Inhibitor 31

Janus-Associated Kinase Inhibitor 31

一种JAK2抑制剂
GC47476 Janthitrem A

11,12-Epoxyjanthitrem B
A mycotoxin
GC38433 Jatrorrhizine

药根碱
An alkaloid with diverse biological activities
GC43926 Jatrorrhizine (chloride)

盐酸药根碱
An alkaloid with diverse biological activities
GC60957 Jatrorrhizine hydroxide Jatrorrhizine (Neprotin, Yatrorizine), one of the active constituents of Coptis chinensis Franch, has multiple bioactivities, such as hypoglycemic, antimicrobial, and antioxidant activities. It is an inhibitor of AChE with IC50 of 872 nM and demonstrates >115-fold selectivity for AChE over BuChE.
GC50681 JHU 37152 JHU 37152 是一种有效的脑渗透性 DREADD 激动剂，在 HEK-293 细胞中对 hM3Dq 和 hM4Di DREADD 的 EC50 分别为 5 nM 和 0.5 nM。