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Home >> Signaling Pathways >> Neuroscience >> mAChR

mAChR(毒蕈碱型乙酰胆碱受体)

mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.

Products for  mAChR

  1. Cat.No. 产品名称 Information
  2. GC34957 (+)-Cevimeline hydrochloride hemihydrate

    (-)-SNI-2011; (-)-AF102B hydrochloride hemihydrate

     (_addition_)-Cevimeline盐酸水合物是mAChR激动剂。
  3. GC70383 (-)-Vesamicol (-)-VesamicolAH5183是乙酰胆碱转运到突触小泡的抑制剂，IC50为75 nM。
  4. GC11219 (R)-(+)-Tolterodine

    托特罗定; (R)-(+)-Tolterodine; (+)-Tolterodine; (R)-Tolterodine; PNU-200583

     (R)-(+)-Tolterodine(PNU-200583) 是一种有效的毒蕈碱受体拮抗剂，在体内对膀胱的选择性优于唾液腺。
  5. GC71634 (R)-Oxybutynin hydrochloride (R)-Oxybutynin hydrochloride盐酸奥昔布宁的R-异构体，是一种口服活性毒蕈碱受体拮抗剂。
  6. GC63452 (Rac)-5-Hydroxymethyl Tolterodine

    苯甲醇,3-[3-[双(1-甲基乙基)氨基]-1-苯基丙基]-4-羟基-,(Rac)-Desfesoterodine; (Rac)-PNU-200577

     (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine) 是 Tolterodine 的一种活性代谢物，是一种 mAChR 拮抗剂 (M1、M2、M3、M4 和 M5 受体的 Ki 值分别为 2.3 nM、2 nM、2.5 nM、2.8 nM 和 2.9 nM)。(Rac)-5-Hydroxymethyl Tolterodine 可用于膀胱过度活动症研究。
  7. GC71582 (Rac)-5-Hydroxymethyl Tolterodine hydrochloride (Rac)-5-Hydroxymethyl Tolterodine hydrochloride是托特罗定的活性代谢产物，是mAChR拮抗剂。
  8. GC30859 AC260584 AC260584是M1毒蕈碱受体变构激动剂，pEC50值为7.6。
  9. GC64332 Aceclidine

    乙酰克里定,Quinuclidin-3-yl acetate

     A muscarinic receptor agonist
  10. GC14096 Aclidinium Bromide

    阿地溴铵; LAS 34273; LAS-W 330

     A muscarinic acetylcholine receptor antagonist
  11. GC10219 AF-DX 116

    11-((2-((二乙氨基)甲基)-1-哌啶基)乙酰基)-5,11-二氢-(6H)-吡啶并[2.3-B][1.4]苯并二氮杂-6-酮,AF-DX 116

     A muscarinic M2 receptor antagonist
  12. GC30996 Alvameline (Lu 25-109)

    Lu 25-109

     Alvameline (Lu 25-109) (Lu25-109) 是一种部分 M1 激动剂和 M2/M3 拮抗剂。
  13. GC31815 Ambutonium bromide (BL700)

    BL700

     Ambutonium bromide (BL700) 是一种乙酰胆碱拮抗剂。
  14. GC60049 Anisodamine hydrobromide

    氢溴酸山莨菪碱,6-Hydroxyhyoscyamine hydrobromide

     Anisodamine (6-Hydroxyhyoscyamine) is a naturally occurring atropine derivative and exhibits anti-inflammatory activity. It also inhibits α1-adrenergic receptors and muscarinic acetylcholine receptors (mAChRs).
  15. GC35381 Arborine

    山柑子碱

     Arborine 可从 Glycosmis arborea 中分离。Arborine 抑制乙酰胆碱的外周作用并诱导血压下降。
  16. GC10264 Arecoline hydrobromide

    氢溴酸槟榔碱

     Muscarinic acetylcholine receptor agonist
  17. GC16526 Atropine

    阿托品; Tropine tropate; DL-Hyoscyamine

     A non-selective muscarinic acetylcholine receptor antagonist
  18. GC35427 Atropine methyl bromide

    甲溴阿托品; Methylatropine bromide

     A muscarinic acetylcholine receptor antagonist
  19. GC35428 Atropine sulfate

    硫酸阿托品; 硫酸阿妥品; 硫酸阿托平; 硫酸阿脱品; Tropine tropate sulfate; DL-Hyoscyamine sulfate; Sulfatropinol

     A non-selective muscarinic acetylcholine receptor antagonist
  20. GC63827 Atropine sulfate monohydrate

    硫酸阿托品; Tropine tropate sulfate monohydrate; DL-Hyoscyamine sulfate monohydrate

     A non-selective muscarinic acetylcholine receptor antagonist
  21. GC31690 Batefenterol (GSK961081)

    GSK961081; TD-5959

     A muscarinic receptor antagonist and β2-adrenergic receptor agonist
  22. GC35492 Benzamide Derivative 1 Benzamide Derivative 1是来自专利EP0213775A1，化合物18，的苯甲酰胺衍生物。Benzamide Derivative 1可能用于治疗胃肠疾病的研究。
  23. GC30925 Benzetimide hydrochloride (R4929)

    盐酸苄替米特,R4929

    A muscarinic acetylcholine receptor antagonist
  24. GC16791 Benztropine mesylate

    甲磺酸苯扎托品; Benzatropine mesylate; Benzotropine mesylate; Benztropine methanesulfonate

     An M1 muscarinic acetylcholine receptor antagonist
  25. GC31942 Beperidium iodide (SX 810)

    贝哌碘铵,SX 810

     Beperidium iodide (SX 810) 对乙酰胆碱受体具有竞争性拮抗作用，pA2 为 7.93。
  26. GC14419 Bethanechol chloride

    氯贝胆碱; Carbamyl-β-methylcholine chloride

     A muscarinic acetylcholine receptor agonist
  27. GC35524 Biperiden

    比哌立登; 碧卜利旦; KL 373

     Biperiden(KL 373)有抗帕金森症活性，是中枢M1胆碱受体阻断剂。
  28. GC10621 Biperiden HCl

    盐酸比哌立登; KL 373 hydrochloride

    A muscarinic acetylcholine receptor antagonist
  29. GC15758 BQCA

    1-(4-甲氧基苄基)-4-氧代-1,4-二氢喹啉-3-羧酸

     A positive allosteric modulator of the M1 mAChR
  30. GC32039 BTM-1086 BTM-1086是一种有效的抗溃疡和胃分泌抑制剂。
  31. GC31072 Camylofine

    卡米罗芬

    Camylofin是一种抗胆碱剂,是一种平滑肌松弛剂。
  32. GC16937 Carbamoylcholine chloride

    Carbachol

    Cholinergic receptor agonist
  33. GC31255 CDD0102 (CDD0102A)

    CDD0102A

     CDD0102 (CDD0102A) 是一种有效的 M1 毒蕈碱受体激动剂。
  34. GC14215 Cevimeline

    西维美林; AF102B

     A muscarinic receptor agonist
  35. GC43232 Cevimeline (hydrochloride)

    盐酸西维美林; AF102B hydrochloride

     A muscarinic receptor agonist
  36. GC17157 Cevimeline hydrochloride hemihydrate

    盐酸西维美林半水合物; SNI-2011; AF102B hydrochloride hemihydrate

     Cevimeline hydrochloride hemihydrate (SNI-2011) 是乙酰胆碱的奎宁环衍生物，是一种选择性和口服活性的毒蕈碱 M1 和 M3 受体激动剂。
  37. GC38693 Choline bitartrate

    酒石酸氢胆碱

     Choline bitartrate (2-hydroxyethyl(trimethyl)azanium, 2,3,4-trihydroxy-4-oxobutanoate) is a form of the nutrient choline which is found in foods. Choline is necessary for normal liver and kidney function and a component of the neurotransmitter acetylcholine, a chemical that facilitates communication between the nerves and muscles.
  38. GC30955 Cimetropium Bromide (DA-3177)

    西托溴铵; DA-3177

     Cimetropium Bromide (DA-3177) (DA-3177) 是一种 mAChR 拮抗剂，用于长期治疗肠易激综合征。
  39. GC31048 Clidinium bromide (Ro 2-3773)

    克利溴铵,Ro 2-3773

     A muscarinic receptor antagonist
  40. GC17760 Clozapine

    氯氮平; HF 1854

     An atypical antipsychotic
  41. GC50193 Clozapine - d8

    HF 1854-d8

     Clozapine - d8 (HF 1854-d8) 是氘标记的氯氮平。
  42. GC10822 Clozapine N-oxide (CNO)

    氯氮平N-氧化物

     Clozapine N-oxide（CNO）是一种强效的多巴胺拮抗剂，也是一种选择性肌动蛋白M4受体（EC50=11 nM）激动剂。
  43. GC31209 Cyclodrine hydrochloride

    盐酸环戊君

     Cyclodrinehydrochloride是一种胆碱能(毒蕈碱，烟碱)受体(mAChR和nAChR)拮抗剂。
  44. GC43347 Cyclopentolate (hydrochloride)

    盐酸环喷托酯,DL-Cyclopentolate hydrochloride

     A muscarinic receptor antagonist
  45. GC72907 Cycrimine

    赛克立明

     Cycrimine是一种口服活性毒蕈碱胆碱能受体（mAChR）M1拮抗剂，可降低帕金森模型中的乙酰胆碱水平。
  46. GC31136 Darenzepine

    达仑西平

     Darenzepine是一种毒蕈碱受体抑制剂，来自专利US20170095465A1。
  47. GC35810 Darifenacin

    达非那新,(±)-UK-88525

     Darifenacin HBr (UK-88525) is a selective M3 muscarinic receptor antagonist with pKi of 8.9.
  48. GC15772 Darifenacin HBr

    氢溴酸达非那新; UK-88525 hydrobromide

     A muscarinic M3 receptor antagonist
  49. GC60758 Deschloroclozapine

    氯氮平杂质

     Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs (muscarinic Designer Receptors Exclusively Activated by Designer Drugs) agonist, and binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively.
  50. GC74124 Deschloroclozapine dihydrochloride Deschloroclozapine dihydrochloride氯氮平的代谢产物，是一种强效毒蕈碱类DREADDs激动剂。
  51. GC35842 Desfesoterodine

    (R)-5-羟甲基托特罗定; PNU-200577; 5-Hydroxymethyl Tolterodine

     5-hydroxymethyl Tolterodine (PNU 200577, 5-HMT, 5-HM,Desfesoterodine) is a new muscarinic receptor antagonist with Kb of 0.84 nM.

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