mAChR
mAChR(毒蕈碱型乙酰胆碱受体)
mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.
mAChR 相关产品(183)
- GC31017ENS-163 phosphate (ENS 213-163)CAS: 117707-51-4
ENS-163 phosphate (ENS 213-163) 是一种选择性毒蕈碱 M1 受体激动剂。
- GC31209Cyclodrine hydrochlorideCAS: 78853-39-1
Cyclodrinehydrochloride是一种胆碱能(毒蕈碱，烟碱)受体(mAChR和nAChR)拮抗剂。
- GC31262Vinconate (Chanodesethylapovinc amine)CAS: 70704-03-9
Vinconate (Chanodesethylapovinc amine) 是一种吲哚萘啶衍生物，可刺激毒蕈碱乙酰胆碱受体。
- GC31690Batefenterol (GSK961081)CAS: 743461-65-6纯度: >99.00%
A muscarinic receptor antagonist and β 2 -adrenergic receptor agonist
- GC31761Revefenacin (TD-4208)CAS: 864750-70-9纯度: >98.00%
Revefenacin (TD-4208, GSK-1160724) is a potent, lung-selective, long-acting muscarinic antagonist that may be for the treatment of respiratory disease.
- GC31942Beperidium iodide (SX 810)CAS: 86434-57-3纯度: >99.50%
Beperidium iodide (SX 810) 对乙酰胆碱受体具有竞争性拮抗作用，pA2 为 7.93。
- GC31946Methylbenactyzium BromideCAS: 3166-62-9纯度: >98.00%
Methylbenactyzine Bromide (Gastrimade, Noinarin, Paragone, Semulgin) is a kind of muscarinic cholinergic receptor antagonist with antispasmodic activity.
- GC32049Oxitropium BromideCAS: 30286-75-0
Oxitropiumbromide是毒蕈碱受体拮抗剂。它是一种用于治疗哮喘和慢性阻塞性肺疾病的抗胆碱能支气管扩张剂药物。
- GC32666Timepidium bromide (Sesden)CAS: 35035-05-3
Timepidium bromide (Sesden) (Sesden; SA504) 是一种抗胆碱能药物。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC31017 | ENS-163 phosphate (ENS 213-163) | 117707-51-4 | - | |
ENS-163 phosphate (ENS 213-163) 是一种选择性毒蕈碱 M1 受体激动剂。 | ||||
| GC31035 | Rispenzepine | 96449-05-7 | - | |
Rispenzepine是一种选择性毒蕈碱受体(M1和M3受体亚型)拮抗剂。 | ||||
| GC31042 | Propantheline bromide | 50-34-0 | - | |
An anticholinergic agent | ||||
| GC31048 | Clidinium bromide (Ro 2-3773) | 3485-62-9 | >98.00% | |
A muscarinic receptor antagonist | ||||
| GC31056 | Piperidolate | 82-98-4 | >99.00% | |
Piperidolate是一种抗胆碱剂，作用于大鼠和狗，可抑制乙酰胆碱引起的肠抽筋。 | ||||
| GC31072 | Camylofine | 54-30-8 | - | |
Camylofin是一种抗胆碱剂,是一种平滑肌松弛剂。 | ||||
| GC31086 | TAK-071 | 1820812-16-5 | >98.50% | |
TAK-071是一种新型,高效，选择性的毒蕈碱乙酰胆碱受体1(M1R)正变构调节剂。TAK-071激活M1R的EC50为520nM。 | ||||
| GC31136 | Darenzepine | 84629-61-8 | - | |
Darenzepine是一种毒蕈碱受体抑制剂，来自专利US20170095465A1。 | ||||
| GC31209 | Cyclodrine hydrochloride | 78853-39-1 | - | |
Cyclodrinehydrochloride是一种胆碱能(毒蕈碱，烟碱)受体(mAChR和nAChR)拮抗剂。 | ||||
| GC31255 | CDD0102 (CDD0102A) | 146422-58-4 | - | |
CDD0102 (CDD0102A) 是一种有效的 M1 毒蕈碱受体激动剂。 | ||||
| GC31262 | Vinconate (Chanodesethylapovinc amine) | 70704-03-9 | - | |
Vinconate (Chanodesethylapovinc amine) 是一种吲哚萘啶衍生物，可刺激毒蕈碱乙酰胆碱受体。 | ||||
| GC31265 | Tematropium (CDDD3602) | 113932-41-5 | - | |
Tematropium (CDDD3602) (CDDD3602) 是一种软性抗胆碱能药。 | ||||
| GC31690 | Batefenterol (GSK961081) | 743461-65-6 | >99.00% | |
A muscarinic receptor antagonist and β 2 -adrenergic receptor agonist | ||||
| GC31761 | Revefenacin (TD-4208) | 864750-70-9 | >98.00% | |
Revefenacin (TD-4208, GSK-1160724) is a potent, lung-selective, long-acting muscarinic antagonist that may be for the treatment of respiratory disease. | ||||
| GC31815 | Ambutonium bromide (BL700) | 115-51-5 | - | |
Ambutonium bromide (BL700) 是一种乙酰胆碱拮抗剂。 | ||||
| GC31942 | Beperidium iodide (SX 810) | 86434-57-3 | >99.50% | |
Beperidium iodide (SX 810) 对乙酰胆碱受体具有竞争性拮抗作用，pA2 为 7.93。 | ||||
| GC31946 | Methylbenactyzium Bromide | 3166-62-9 | >98.00% | |
Methylbenactyzine Bromide (Gastrimade, Noinarin, Paragone, Semulgin) is a kind of muscarinic cholinergic receptor antagonist with antispasmodic activity. | ||||
| GC31984 | M3 receptor antagonist 1 | 1004312-94-0 | - | |
M3 受体拮抗剂 1 是一种选择性、长效和竞争性毒蕈碱 M3 受体拮抗剂。 | ||||
| GC32039 | BTM-1086 | 72293-17-5 | - | |
BTM-1086是一种有效的抗溃疡和胃分泌抑制剂。 | ||||
| GC32049 | Oxitropium Bromide | 30286-75-0 | - | |
Oxitropiumbromide是毒蕈碱受体拮抗剂。它是一种用于治疗哮喘和慢性阻塞性肺疾病的抗胆碱能支气管扩张剂药物。 | ||||
| GC32416 | YM-46303 | 171722-81-9 | - | |
YM-46303是一种毒蕈碱受体拮抗剂，对M1和M3受体表现出最高的亲和力，对M3受体的选择性较M2受体高。 | ||||
| GC32478 | Pirmenol hydrochloride (Cl-845) | 61477-94-9 | >98.00% | |
A class I antiarrhythmic agent | ||||
| GC32666 | Timepidium bromide (Sesden) | 35035-05-3 | - | |
Timepidium bromide (Sesden) (Sesden; SA504) 是一种抗胆碱能药物。 | ||||
| GC32667 | Nuvenzepine | 96487-37-5 | >99.00% | |
Nuvenzepine是mAChR的拮抗剂，之前在临床一期试验中用来治疗胃痉挛。 | ||||