Propantheline is an anticholinergic agent.1,2,3 It inhibits contraction of isolated guinea pig ileum induced by acetylcholine and reduces intensity of vagal-stimulated gastric contractions in rats.1 Propantheline (5 mg/kg, s.c.) increases gastric pH and prevents pyloric ligature-induced gastric ulcer formation in Shay rats.2 It also inhibits basal and pentagastrin-, but not histamine-, stimulated gastric secretion in a rhesus monkey model of chronic gastric fistula.3 Formulations containing propantheline have been used to treat stomach and intestinal spasms associated with irritable bowel syndrome.
1.Aarsen, P.N., and Noordwijk, J.V.The effect of atropine, propantheline and poldine on the vagally stimulated gastric motility and the histamine-stimulated acid gastric secretion in the ratBr. J. Pharmacol. Chemother.1741-50(1961) 2.Kowalewski, K., MacKenzie, W.C., Shnitka, T.K., et al.Protective action of pro-banthine (SC-3171) on experimental gastric ulcers of ratsCan. Med. Assoc. J.71(5)477-482(1954) 3.Dajani, E.Z., Callison, D.A., and Bianchi, R.G.Gastric antisecretory effects of propantheline bromide and metiamide in rhesus monkeysArch. Int. Pharmacodyn. Ther.234(1)107-117(1978)