Clidinium is a gastrointestinal muscarinic receptor antagonist (Ki = 3 nM against [3H]quinuclidinyl benzilate binding in rat colonic enterocytes).1 Administration of clidinium, at a dose of 1 mg/kg, slows intestinal transit and induces constipation in mice.2 This clidinium-induced constipation induces serum hyperammonemia and decreases clonic, myoclonic, and tonic seizure thresholds in a murine pentylenetetrazole-induced epilepsy model.
1.Zimmerman, T.W., and Binder, H.J.Muscarinic receptors on rat isolated colonic epithelial cells. A correlation between inhibition of [3H]quinuclidinyl benzilate binding and alteration in ion transportGastroenterology83(6)1244-1251(1982) 2.Moezi, L., Pirsalami, F., and Inaloo, S.Constipation enhances the propensity to seizure in pentylenetetrazole-induced seizure models of miceEpilepsy Behav.44200-206(2015)