San78-130 is a selective and potent ALK1 inhibitor with an IC50 of 62 nM. San78-130 also inhibits FLT4/VEGFR3, KDR/VEGFR2, MEK2, and FLT3 with IC50s of 114, 162, 186.7, and 188 nM, respectively[1]. ALK1|62 nM (IC50)|FLT4/VEGFR3|114 nM (IC50)|KDR/VEGFR2|162 nM (IC50)|MEK2|186.7 nM (IC50)|FLT3|188 nM (IC50)
[1]. Cho H, et al. Identification of the First Selective Activin Receptor-Like Kinase 1 Inhibitor, a Reversible Version of L-783277. J Med Chem. 2017 Feb 23;60(4):1495-1508.