GlpBio

mAChR

mAChR(毒蕈碱型乙酰胆碱受体)

mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.

mAChR 相关产品(183)

  • GC33434 structure
    GC33434Methacholine chloride
    CAS: 62-51-1
    纯度: >98.00%

    Methacholine chloride是一种有效的毒蕈碱受体激动剂。Methacholine chloride能够直接作用于平滑肌上的乙酰胆碱受体，导致支气管收缩和气道变窄。

  • GC33878 structure
    GC33878Irsogladine maleate (Dicloguamine maleate)
    CAS: 84504-69-8

    A gastroprotective agent

  • GC34957 structure
    GC34957(+)-Cevimeline hydrochloride hemihydrate
    CAS: 153504-70-2
    纯度: >98.00%

    (_addition_)-Cevimeline盐酸水合物是mAChR激动剂。

  • GC35381 structure
    GC35381Arborine
    CAS: 6873-15-0

    Arborine 可从 Glycosmis arborea 中分离。Arborine 抑制乙酰胆碱的外周作用并诱导血压下降。

  • GC35427 structure
    GC35427Atropine methyl bromide
    CAS: 2870-71-5

    A muscarinic acetylcholine receptor antagonist

  • GC35428 structure
    GC35428Atropine sulfate
    CAS: 55-48-1
    纯度: >98.00%

    A non- selective muscarinic acetylcholine receptor antagonist

  • GC35492 structure
    GC35492Benzamide Derivative 1
    CAS: 108226-05-7

    Benzamide Derivative 1是来自专利EP0213775A1，化合物18，的苯甲酰胺衍生物。Benzamide Derivative 1可能用于治疗胃肠疾病的研究。

  • GC35524 structure
    GC35524Biperiden
    CAS: 514-65-8

    Biperiden(KL 373)有抗帕金森症活性，是中枢M1胆碱受体阻断剂。

  • GC35810 structure
    GC35810Darifenacin
    CAS: 133099-04-4
    纯度: >98.00%

    Darifenacin HBr (UK-88525) is a selective M3 muscarinic receptor antagonist with pKi of 8.9.

  • GC35842 structure
    GC35842Desfesoterodine
    CAS: 207679-81-0
    纯度: >99.00%

    5-hydroxymethyl Tolterodine (PNU 200577, 5-HMT, 5-HM,Desfesoterodine) is a new muscarinic receptor antagonist with Kb of 0.84 nM.

  • GC35845 structure
    GC35845Dexetimide
    CAS: 21888-98-2
    纯度: >99.00%

    Dexetimide ((+)-Benzetimide) 是一种高亲和力的毒蕈碱受体拮抗剂，也是强效持久抗胆碱药，可用于治疗神经抑制性帕金森病。

  • GC36442 structure
    GC36442Levetimide
    CAS: 21888-99-3
    纯度: >99.00%

    Levetimide 是一种有效的立体选择性 [3H](+)pentazocine 结合抑制剂，Ki 为 2.2 nM。

  • GC36523 structure
    GC36523mAChR-IN-1
    CAS: 119391-56-9

    mAChR-IN-1是mAChR高效抑制剂，IC50值为17nM。

  • GC36524 structure
    GC36524mAChR-IN-1 hydrochloride
    CAS: 119391-73-0
    纯度: >99.50%

    mAChR-IN-1 hydrochloride是毒蕈碱的胆碱能受体 mAChR 的有效抑制剂，其IC50值为17nM。

  • GC37064 structure
    GC37064Racanisodamine
    CAS: 17659-49-3
    纯度: >98.50%

    A natural α 1 -adrenoceptor antagonist

  • GC37652 structure
    GC37652Smilagenin
    CAS: 126-18-1
    纯度: >98.00%

    Smilagenin (SMI) 是一种脂溶性小分子甾体皂苷元，来自知母 Rhizoma anemarrhenae 和天竺葵 Radix asparagi，广泛用于治疗慢性神经退行性疾病的中药。Smilagenin (SMI) 通过增加毒蕈碱受体亚型 1 (M1)-受体的的密度来改善老年大鼠的记忆。Smilagenin (SMI) 通过刺激脑源性神经营养因子的基因表达减弱 Aβ(25-35) 诱导的神经变性，可能代表 AD 的新型治疗策略。

  • GC37731 structure
    GC37731Talsaclidine
    CAS: 147025-53-4

    Talsaclidine 是一种毒蕈碱激动剂，具有优先神经刺激特性。Talsaclidine 是 M1 亚型的完全激动剂，M2 和M3 亚型的部分激动剂。

  • GC37749 structure
    GC37749TBPB
    CAS: 634616-95-8
    纯度: >99.50%

    An allosteric agonist of M 1 receptors

  • GC37928 structure
    GC37928VU 6008667
    CAS: 2092923-21-0
    纯度: >99.00%

    VU 6008667 是毒蕈碱乙酰胆碱受体亚型 5（M5 NAM）的选择性负变构调节剂，对于人和大鼠的 IC50 值分别为1.2 μM 和 1.6 μM。 VU 6008667具有高CNS渗透率。

  • GC37932 structure
    GC37932VU6005806
    CAS: 2180914-37-6

    VU6005806 (AZN-00016130) 是一种有效的毒蕈乙酰胆碱受体亚型 4 (M4) 的正向别构调节剂，对人、大鼠、狗、猴 M4 的 EC50 值分别为 94 nM，28 nM，87 nM 和 68 nM。用于神经疾病的研究。

  • GC38111 structure
    GC38111Rac-VU 6008667
    CAS: 2092917-63-8

    Rac-VU 6008667 是毒蕈碱乙酰胆碱受体亚型 5 (M5 NAM) 的选择性负变构调节剂，对于人和大鼠的 IC50 值分别为 1.2 μM 和 1.6 μM。Rac-VU 6008667 具有高 CNS 渗透性。

  • GC38658 structure
    GC38658Oxotremorine M iodide
    CAS: 3854-04-4

    Oxotremorine M iodide 是一种有效的，选择性毒蕈碱型乙酰胆碱受体 (mAChR) 激动剂。Oxotremorine M iodide 通过毒蕈碱受体依赖和独立机制增强 NMDA 受体。

  • GC38693 structure
    GC38693Choline bitartrate
    CAS: 87-67-2
    纯度: >99.00%

    Choline bitartrate (2-hydroxyethyl(trimethyl)azanium, 2,3,4-trihydroxy-4-oxobutanoate) is a form of the nutrient choline which is found in foods. Choline is necessary for normal liver and kidney function and a component of the neurotransmitter acetylcholine, a chemical that facilitates communication between the nerves and muscles.

  • GC38933 structure
    GC38933Nebracetam hydrochloride
    CAS: 1177279-49-0

    Nebracetam hydrochloride 是 M1 毒蕈碱的激动剂，会引起胞内 Ca2+ 浓度升高。其 EC50 值为1.59 mM。