Racanisodamine is a natural tropane alkaloid shown to be a weak antagonist of α1-adrenoceptors, blocking WB-4101 and clonidine binding in brain membrane preparations with pKi values of 2.63 and 1.61, respectively.1 Racanisodamine also has antioxidant effects that may protect against free radical-induced cellular damage.2 Racanisodamine is predominantly found in the roots of A. tanguticus, which is used in traditional Chinese medicine for topical applications.3
1.Varma, D.R., and Yue, T.L.Adrenoceptor blocking properties of atropine-like agents anisodamine and anisodine on brain and cardiovascular tissues of ratsBr. J. Pharmacol.87(3)587-594(1986) 2.Poupko, J.M., Baskin, S.I., and Moore, E.The pharmacological properties of anisodamineJ. Appl. Toxicol.27(2)116-121(2007) 3.Ma, L., Gu, R., Tang, L., et al.Important poisonous plants in Tibetan ethnomedicineToxins (Basel)7(1)138-155(2015)