Docosatrienoic acid is a rare ω-3 fatty acid not readily detected in normal phospholipid PUFA pools. It is a polyunsaturated version of the fatty acid docosanoic acid . Docosatrienoic acid inhibits [3H]-LTB4 binding to pig neutrophils at a concentration of 5 ?M.1 It also dose-dependently inhibits the activity of mammalian DNA polymerases and human topoisomerases I and II, potentially by binding directly to the hydrophobic region of the enzymes.2 The cis configuration of the double bonds is important for this activity, and the carboxyl group is required as the methyl ester version has no activity at these enzymes.
1.Yagaloff, K.A., Franco, L., Simko, B., et al.Essential fatty acids are antagonists of the leukotriene B4 receptorProstaglandins, Leukot. Essent. Fatty Acids52(5)293-297(1995) 2.Yonezawa, Y., Hada, T., Uryu, K., et al.Inhibitory action of C22-fatty acids on DNA polymerases and DNA topoisomerasesInt. J. Mol. Med.18(4)583-588(2006)