(S)-Canadine is an alkaloid and intermediate in the biosynthesis of berberine that has been found in H. canadensis and has insecticidal activity.1,2,3,4 (S)-Canadine induces mortality in D. melanogaster larvae (LC50 = 0.91 µmol/ml of diet) and adults (LD50 = 2.5 µg/insect).4
1.Malhotra, S., Taneja, S.C., and Dhar, K.L.Minor alkaloid from Coscinium fenestratumPhytochem.28(7)1998-1999(1989) 2.Galanie, S., and Smolke, C.D.Optimization of yeast-based production of medicinal protoberberine alkaloidsMicrob. Cell Fact.14144(2015) 3.Leyte-Lugo, M., Britton, E.R., Foil, D.H., et al.Secondary metabolites from the leaves of the medicinal plant goldenseal (Hydrastis canadensis)Phytochem. Lett.2054-60(2017) 4.Miyazawa, M., Yoshio, K., Ishikawa, Y., et al.Insecticidal alkaloid against Drosophila melanogaster from tubers of Corydalis bulbosaNat. Prod. Lett.8(4)299-302(1996)