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Home >> Signaling Pathways >> Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for  Proteases

  1. Cat.No. 产品名称 Information
  2. GC71814 α-1-3,4 Fucosyltransferase, helicobacter pylori α-1-3,4 Fucosyltransferase幽门螺杆菌中存在α1,3/4FucT（EC 2.4.1.65）（Hp3/4FT）。
  3. GC71815 α-2,3-Sialyltransferase, pasteurella multocida α-2,3-Sialyltransferase, pasteurella multocida是一种β-半乳糖苷。
  4. GC41183 α-Carotene

    α-胡萝卜素

    A precursor of vitamin A
  5. GC45204 α-Ecdysone

    蜕皮激素; α-Ecdysone

    蜕皮激素（α-蜕皮激素）是一种存在于昆虫和植物中的类固醇蜕皮激素，可激活盐皮质激素受体（MR），从而导致肾小球疾病。
  6. GC45208 α-hydroxy Metoprolol

    Α-羟基美托洛尔

     An active metabolite of metoprolol
  7. GC72837 α-Hydroxyglutaric acid-d4 disodium

    2-Hydroxyglutarate-d4 disodium; 2-Hydroxyglutaric acid-d4 disodium; 2-Hydroxypentanedioic acid-d4 disodium

     α-Hydroxyglutaric acid-d4 disodium为氘标记的α-羟基戊二酸二钠。
  8. GC48948 α-Ketoglutaric Acid (sodium salt)

    LPHA-酮戊二酸钠(2-8℃),Alpha-Ketoglutaric acid Sodium

     An intermediate in the citric acid cycle
  9. GC40718 α-Muricholic Acid

    5β-Cholanic Acid-3α,6β,7α-triol

     A murine-specific primary bile acid
  10. GC40480 α-Phenyl-α-(2-pyridyl)acetonitrile

    alpha-(2-吡啶基)-苯乙腈

     The major metabolite of α-phenyl-α-(2-pyridyl)thioacetamide
  11. GC38287 α-Pyridone

    2-羟基吡啶,Pyridin-2-one; α-Hydroxypyridine

     2-Hydroxypyridine (2-Pyridino, 2-Pyridone) is used in peptide synthesis.
  12. GC71810 β-1,4-Galactosyltransferase, neisseria meningitides β-1,4-Galactosyltransferase, neisseria meningitides通常用于生化研究。
  13. GC45226 β-BHC

    β-HCH, β-Hexachlorocyclohexane, β-Lindane

     β-BHC is an isomer of the organochlorine pesticide γ-lindane that is a potential impurity found in commercial preparations of lindane.
  14. GC38000 β-Boswellic acid

    β-乳香酸

     A pentacyclic triterpene with diverse bioactivities
  15. GC71980 β-Caryophyllene-d2 β-Caryophyllene-d2是氘标记的β-石竹烯。
  16. GC63275 β-Cryptoxanthin

    隐黄质,(3R)-β-Cryptoxanthin

     β-Cryptoxanthin ((3R)-β-Cryptoxanthin) 是从萨摩橘中分离的一种含氧类胡萝卜素，也是有效的抗氧化剂。β-Cryptoxanthin 具有抗应激作用。
  17. GC40777 β-D-Glucose

    D-无水葡萄糖

     A cyclic monosaccharide
  18. GC66842 β-Methylcrotonyl coenzyme A lithium β-Methylcrotonyl coenzyme A lithium 是亮氨酸代谢的中间体，可被用作底物来研究 β-甲基巴豆酰辅酶 A 羧化酶 (MCCase) 的特异性和动力学。
  19. GC40719 β-Muricholic Acid

    Β-鼠胆酸,5β-Cholanic Acid-3α,6β,7β-triol, β-MCA

     β-胆酸β-muricholic acid是一种天然存在的三羟基亲水性胆汁酸，作为胆道胆固醇去饱和剂，促进胆固醇胆结石的溶解。
  20. GC67484 β-Nicotinamide adenine dinucleotide reduced dipotassium β-Nicotinamide adenine dinucleotide reduced dipotassium 是一种口服有效的还原型辅酶。β-Nicotinamide adenine dinucleotide reduced dipotassium 还是 ADP-核糖基转移酶反应中的 ADP-核糖单元的供体和环状 ADP-核糖的前体。β-Nicotinamide adenine dinucleotide reduced dipotassium 在细胞的能量代谢过程中起到再生电子供体的作用，包括糖酵解，β-氧化和三羧酸 (TCA) 循环。
  21. GC70185 β-Sitostenone

    δ4-Sitosterol-3-one; β-Rosasterol oxide

     β-Sitostenone 是一种从 Cochlospermum vitifolium 中分离得到的甾醇。β-Sitostenone 可抑制酪氨酸酶 (tyrosinase) 活性，并具有抗黑色素生成和抗肿瘤活性。
  22. GC38010 γ-Aminobutyric acid

    γ-氨基丁酸

     γ-氨基丁酸（γ-Aminobutyric acid，GABA）是成人大脑中的主要抑制性神经递质。
  23. GC63279 γ-Glu-Gly TFA γ-Glu-Gly 是一种 γ-谷氨酰二肽，是一种人体脂质代谢物。γ-Glu-Gly 与 GABA (γ-氨基丁酸)结构相似，可作为兴奋性氨基酸的拮抗剂。
  24. GC38011 γ-Secretase modulator 4 γ-Secretase modulator 4 是一种有效的 γ- 分泌酶调节剂 (γ-secretase)，在人类和小鼠中降低 Aβ42 产生的 IC50 值分别为 0.014 μM 和 0.017 μM。
  25. GC66048 δ-Secretase inhibitor 11 Compound 11, a non-toxic and selective δ-secretase inhibitor (IC50=0.7 μM, in fluorescence-based assay) that interacts with both the active site and allosteric site of δ-secretase in Co-crystal structure analysis. The IC50 value of the compound 11 towards δ-secretase in Pala cells is 0.8 μM.
  26. GC15975 α-Estradiol

    α-雌二醇; Alfatradiol; Epiestradiol; Epiestrol

     A weak estrogen with neuroprotective effects
  27. GC30187 γ-Glu-Phe (γ-Glutamylphenylalanine)

    γ-Glutamylphenylalanine

     γ-Glu-Phe (γ-Glutamylphenylalanine) (γ-Glutamylphenylalanine) 由解淀粉芽孢杆菌 (GBA) 和米曲霉 (GAO) 合成。
  28. GC41552 ω-3 Arachidonic Acid

    ω3 AA

     A rare, natural 20:4 ω-3 polyunsaturated fatty acid
  29. GC40259 (±)-β-Tocopherol

    β-生育酚

     A lipid-soluble form of vitamin E
  30. GC40260 (±)-γ-Tocopherol

    3,4-二氢-2,7,8-三甲基-2-(4,8,12-三甲基十三烷)-2H-1-苯并吡喃-6-醇

     A form of vitamin E
  31. GC41661 (±)-4-hydroxy Propranolol β-D-Glucuronide

    (+/-)-4-羟基普萘洛尔葡糖苷酸

     A metabolite of propranolol
  32. GC34961 (±)-BI-D

    人BH3结构域凋亡诱导蛋白(BID)ELISA试剂盒

     (_plusmn_)-BI-D是HIV整合酶（integrase）变构抑制剂，作用于整合酶与LEDGF/p75结合部位。
  33. GC46284 (±)-Cotinine-d3

    氘代甲基可替宁,(±)-Cotinine-d3; (Rac)-NIH-10498-d3

     An internal standard for the quantification of cotinine
  34. GC41670 (±)-Epinephrine (hydrochloride)

    肾上腺素盐酸盐

     An adrenergic receptor agonist
  35. GC41671 (±)-Equol 4'-sulfate (sodium salt)

    R,S-Equol 4'-Sulfate

     A metabolite of (±)-equol
  36. GC41315 (±)-Ketoprofen Glucuronide

    (酮洛芬酰基)-Β-D-葡糖苷酸

     A metabolite of ketoprofen
  37. GC38369 (±)-Leucine

    DL-亮氨酸,DL-Leucine; (RS)-Leucine

     (±)-Leucine 是一种内源性代谢产物。
  38. GC65599 (±)-Leucine-d10

    DL-亮氨酸-2,3,3,4,5,5,5,5′,5′,5′-D10,DL-Leucine-d10; (RS)-Leucine-d10

     (±)-Leucine-d10 (DL-Leucine-d10) 是 (±)-Leucine 的氘代物。(±)-Leucine (DL-Leucine)，亮氨酸的异构体，是一种化学杀菌剂和膳食添加剂。(±)-Leucine 抑制大肠杆菌的生长达92.08%。
  39. GC49875 (±)-N-desmethyl Venlafaxine (hydrochloride)

    盐酸文拉法辛杂质D

     A minor active metabolite of venlafaxine
  40. GC39271 (±)-Naringenin

    (±)-柚皮素

     A citrus-derived flavonoid
  41. GC13890 (±)-Palmitoylcarnitine chloride

    C16:0 Carnitine, CAR 16:0, DL-Carnitine hexadecanoyl ester, DL-Carnitine palmitoyl ester, Hexadecanoyl-DL-carnitine, DL-Hexadecanoylcarnitine, NSC 628323, DL-Palmitoylcarnitine

     A long-chain acylcarnitine with intracellular and extracellular roles
  42. GC46308 (±)-Sitagliptin-d4 (hydrochloride) A neuropeptide with diverse biological activities
  43. GC40229 (±)-Warfarin-d5

    4-羟基-3-[3-氧代-1-(苯基-D5)丁基]-2H-1-苯并吡喃-2-酮,WARF-42-d5; Athrombine-K-d5

     An internal standard for the quantification of warfarin
  44. GC40539 (±)12(13)-EpOME

    (±)12,13-EODE, Isoleukotoxin, (±)-Vernolic Acid

     The 12,13-cis epoxide form of linoleic acid
  45. GC48738 (±)12-HETE-d8

    (±)12-Hydroxyeicosatetraenoic Acid-d8

     An internal standard for the quantification of 12-HETE
  46. GC41649 (±)13-HODE cholesteryl ester A 15-LO product derived from cholesteryl linoleate
  47. GC48739 (±)15-HETE-d8

    (±)15-Hydroxyeicosatetraenoic Acid-d8

     An internal standard for the quantification of 15-HETE
  48. GC19444 (±)20-HDHA

    (±)20-HDoHE

     An autoxidation product of DHA and potential marker of oxidative stress
  49. GC40828 (±)5-HETE lactone

    (±)5-Hydroxyeicosatetraenoic Acid lactone

     A 5-LO inhibitor
  50. GC40442 (±)8-HETE

    (±)8-Hydroxyeicosatetraenoic Acid

     A monohydroxy fatty acid produced by the non-enzymatic oxidation of arachidonic acid
  51. GC40801 (±)9(10)-DiHOME

    (±)-苏式-9,10-二羟基-12(Z)-十八碳烯酸

     A diol form of (±)9(10)-EpOME

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