GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC15952 structure
    GC15952CL 82198 hydrochloride
    CAS: 1188890-36-9
    纯度: >98.00%

    An inhibitor of MMP-13

  • GC16774 structure
    GC16774Boc-D-FMK
    CAS: 634911-80-1
    纯度: >95.00%

    Boc-D-FMK is a cell-permeable broad-spectrum caspase inhibitor that fully inhibits the pro-apoptotic effect of tumor necrosis factor-α (TNFα) with the half maximal inhibition concentration IC50 value of 39 μM .

  • GC10968 structure
    GC10968Ac-LEHD-AFC
    CAS: 210345-03-2

    A caspase-4, -5, and -9 fluorogenic substrate

  • GC12157 structure
    GC12157CP 471474
    CAS: 210755-45-6

    A broad-spectrum MMP inhibitor

  • GC13099 structure
    GC13099BMS 299897
    CAS: 290315-45-6
    纯度: >98.50%

    A γ-secretase inhibitor

  • GC15335 structure
    GC15335Saquinavir
    CAS: 127779-20-8
    纯度: >99.00%

    Saquinavir (Ro 31-8959) 是一种 HIV 蛋白酶抑制剂，用于抗逆转录病毒治疗。

  • GC10327 structure
    GC10327Retaspimycin
    CAS: 857402-23-4

    Retaspimycin 是一种有效的 Hsp90 抑制剂，对 Hsp90 和 Grp9 的 EC50 均为 119 nM。

  • GC15005 structure
    GC15005ONO 4817
    CAS: 223472-31-9

    An inhibitor of MMP-2 and MMP-9

  • GC15785 structure
    GC15785Saquinavir mesylate
    CAS: 149845-06-7
    纯度: >98.50%

    An HIV protease inhibitor

  • GC12111 structure
    GC12111PD 166793
    CAS: 199850-67-4
    纯度: >99.00%

    An broad-spectrum MMP inhibitor

  • GC12190 structure
    GC12190Z-WEHD-FMK
    CAS: 210345-00-9
    纯度: >98.50%

    Z-WEHD-FMK 是一种有效的、细胞渗透性和不可逆的 caspase-1/5 抑制剂。 Z-WEHD-FMK 还表现出对组织蛋白酶 B 活性的强大抑制作用 (IC50=6 μM)。 Z-WEHD-FMK 可用于研究细胞凋亡的证据。

  • GC14454 structure
    GC14454Tipranavir
    CAS: 174484-41-4
    纯度: >98.00%

    A nonpeptidic HIV protease inhibitor

  • GC10805 structure
    GC10805Ro 32-3555
    CAS: 190648-49-8

    Ro 32-3555 是一种有效的、竞争性的人类胶原酶 1、2 和 3 抑制剂，Kis 分别为 3.0、4.4 和 3.4 nM。

  • GC13946 structure
    GC13946SNX-2112
    CAS: 908112-43-6

    SNX-2112是一种强效的合成型热休克蛋白（Hsp 90）抑制剂，IC 50 值为30nM。

  • GC16579 structure
    GC16579UK 370106
    CAS: 230961-21-4

    UK 370106 是一种有效且高度选择性的 MMP-3（IC50 为 23 nM）和 MMP-12（IC50 为 42 nM）抑制剂，其效力比 MMP-1、MMP-2、MMP-9 和 MMP 高 1200 倍以上-14，大约是 MMP-13 和 MMP-8 的 100 倍。

  • GC13707 structure
    GC13707WAY 170523
    CAS: 307002-73-9

    WAY 170523 是一种有效的选择性 MMP-13（基质金属蛋白酶 13）抑制剂，IC50 为 17 nM。 WAY 170523 可以直接减弱 ERK1/2 磷酸化。 WAY 170523抑制PC-3细胞的侵袭，可用于前列腺癌研究。

  • GC10258 structure
    GC10258Ac-IEPD-AFC
    CAS: 1135417-31-0

    Ac-IEPD-AFC 是颗粒酶 B 的底物。

  • GC12139 structure
    GC12139Gambogic Acid
    CAS: 2752-65-0

    Gambogic Acid 是一种细胞渗透性 caspase 激活剂和细胞凋亡诱导剂，常用于乳腺癌、肺癌和肝癌等的研究。

  • GC15891 structure
    GC15891Nesbuvir
    CAS: 691852-58-1
    纯度: >98.50%

    Nesbuvir 是丙型肝炎病毒 (HCV) 非结构蛋白 5B (NS5B) 聚合酶的非核苷抑制剂。

  • GC11513 structure
    GC11513Zofenopril calcium
    CAS: 81938-43-4
    纯度: >99.50%

    A prodrug form of zofenoprilat

  • GC11615 structure
    GC11615GW311616
    CAS: 198062-54-3
    纯度: >99.50%

    GW-311616 是一种有效的、可口服的、长效的、选择性的人中性粒细胞弹性蛋白酶 (HNE) 抑制剂，IC50 值为 22 nM，Ki 值为 0.31 nM。

  • GC13851 structure
    GC13851GW311616 hydrochloride
    CAS: 197890-44-1
    纯度: >98.50%

    An inhibitor of neutrophil elastase

  • GC13952 structure
    GC13952Trandolapril
    CAS: 87679-37-6
    纯度: >99.50%

    A prodrug form of trandolaprilat