Lipoxygenase(脂氧合酶)

Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.

Products for Lipoxygenase

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Cat.No. 产品名称 Information
GC38000 β-Boswellic acid

β-乳香酸
A pentacyclic triterpene with diverse bioactivities
GC48738 (±)12-HETE-d8

(±)12-Hydroxyeicosatetraenoic Acid-d8
An internal standard for the quantification of 12-HETE
GC41649 (±)13-HODE cholesteryl ester A 15-LO product derived from cholesteryl linoleate
GC48739 (±)15-HETE-d8

(±)15-Hydroxyeicosatetraenoic Acid-d8
An internal standard for the quantification of 15-HETE
GC40828 (±)5-HETE lactone

(±)5-Hydroxyeicosatetraenoic Acid lactone
A 5-LO inhibitor
GC41666 (±)9-HODE cholesteryl ester A racemic monohydroxy fatty acid cholesteryl ester
GC90533 (-)-Pinoresinol
一种具有多种生物活性的木脂素
GC41770 1,2,3-Trieicosapentaenoyl-rac-glycerol

二十碳五烯酸甘油三酯(CIS-5,8,11,14,17)
A polyunsaturated triacylglycerol
GC45948 1,2,3-Trilinoelaidoyl-rac-glycerol

十八碳二烯酸甘油三酯(TRANS-9,12)
A triacylglycerol
GC42039 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC

15(S)-HETE-SAPC, 15(S)-Hydroxyeicostetraenoic Acid-SAPC, 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylcholine
An oxidized phospholipid
GC42040 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE

15(S)-HETE-SAPE, 15(S)-Hydroxyeicosatetraenoic Acid-SAPE, 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylethanolamine

An oxidized phospholipid
GC49730 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11

15(S)-HETE-SAPE-d11, 15(S)-Hydroxyeicosatetraenoic Acid-SAPE-d11, 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylethanolamine-d11
An internal standard for the quantification of 1-stearoyl-2-15(S)-HETE-sn-glycero-3-PE
GC42041 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC

15(S)-HpETE-SAPC, 15(S)-Hydroperoxyeicostetraenoic Acid-SAPC, 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Phosphatidylcholine

An oxidized phospholipid
GC42042 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE

1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-phosphoethanolamine, 15(S)-HpETE-SAPE, 15(S)-hydroperoxyeicostetraenoic acid-SAPE

An oxidized phospholipid
GC40971 10(S),17(S)-DiHDHA

10(S),17(S)-DiHDoHE; PDX
A DHA derivative with anti-inflammatory and anti-platelet activity
GC40368 11(R)-HEPE Produced by the oxidation of EPA by 11(R)-LO
GC40445 11(R)-HETE

11(R)-Hydroxyeicosatetraenoic Acid
An oxylipin
GC10821 11-keto-β-Boswellic Acid

11-酮基-BETA-乳香酸,11-oxo-β-Boswellic acid,KBA
A 5-LO inhibitor
GC41144 11-trans Leukotriene C4

11trans LTC4
A C-11 double bond isomer of LTC₄
GC41147 11-trans Leukotriene D4

11trans LTD4
A C-11 double bond isomer of LTD₄
GC41149 11-trans Leukotriene E4

11trans LTE4
The C-11 double bond isomer of LTE₄
GC40447 12(R)-HETE

12(R)-Hydroxyeicosatetraenoic Acid
An active metabolite of arachidonic acid
GC40371 12(S)-HEPE An anti-inflammatory monohydroxy fatty acid derived from EPA
GC40448 12(S)-HETE

12(S)-Hydroxyeicosatetraenoic Acid
The predominant lipoxygenase product of mammalian platelets
GC40349 12(S)-HETE-19,20-alkyne

Click Tag 12(S)-HETE-19,20-alkyne, Click Tag 12(S)-Hydroxyeicosatetraenoic Acid-19,20-alkyne
A probe for 12(S)-HETE activity
GC41882 12(S)-HETrE An inhibitor of platelet activation
GC41095 12(S)-HpEPE A 12-LO product derived from EPA
GC41122 12(S)-HpETE
A 12-LO metabolite of arachidonic acid
GC41123 12-epi Leukotriene B4

12epi LTB4
LTB₄ isomer with weak agonist activity at BLT₁ and BLT₂ receptors
GC46416 12-epi Leukotriene B4-d4

12epi LTB4d4
A neuropeptide with diverse biological activities
GC41096 12-oxo Leukotriene B4

12keto LTB4, 12oxo LTB4
A natural metabolite of LTB₄
GC46418 12-oxo-13-HOME An oxylipin
GC90652 12-oxo-9(Z)-Dodecenoic Acid

12-keto-9Z-Dodecenoic Acid, 12-oxo-9-cis-Dodecenoic Acid

亚油酸和亚麻酸的代谢产物。
GC40372 12-OxoETE

12-KETE
A 12-oxo derivative of arachidonic acid
GC19462 13(R)-HODE An enantiomer of 13(S)-HODE
GC19463 13(S)-HODE

13(S)-HODE

Product of 15-LO metabolism of linoleic acid
GC41220 13(S)-HODE methyl ester Hydroxy fatty acid methyl ester
GC41896 13(S)-HODE-biotin A biotinylated PUFA
GC46420 13(S)-HODE-d4 An internal standard for the quantification of 13-HODE
GC41897 13(S)-HOTrE A 15-LO product derived from GLA
GC41898 13(S)-HOTrE(γ) A 15-LO product derived from GLA
GC19474 13(S)-HpODE Stimulates EGF-dependent mitogenesis and tyrosine phosphorylation
GC41899 13(S)-HpOTrE
A product of soybean LO-2 metabolism of α-linolenic acid
GC41900 13(S)-HpOTrE(γ) Produced by the action of soybean LO-1 on γ-linolenic acid
GC41911 13-epi-12-oxo Phytodienoic Acid

13-EPI-12-氧代植物二烯酸
A lipoxygenase metabolite of α-linolenic acid
GC46436 13-OxoODE-d3

13KODEd3
A neuropeptide with diverse biological activities
GC41206 14(S)-HDHA

14(S)-HDoHE
An anti-inflammatory lipid produced by macrophages
GC41100 14,15-dehydro Leukotriene B4

14,15dehydro LTB4
A LTB₄ receptor antagonist
GC41145 14,15-Leukotriene C4

Eoxin C4, EXC4, 14,15LTC4
A pro-inflammatory arachidonic acid metabolite
GC41148 14,15-Leukotriene D4

Eoxin D4, EXD4, 14,15-LTD4
A pro-inflammatory arachidonic acid metabolite