Lipoxygenase
Lipoxygenase(脂氧合酶)
Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.
Lipoxygenase 相关产品(254)
- GC38000β-Boswellic acidCAS: 631-69-6纯度: >98.50%
A pentacyclic triterpene with diverse bioactivities
- GC39013FPL 62064CAS: 103141-09-9纯度: >98.00%
FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and prostaglandin synthetase (cyclooxygenase, COX) with IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and seminal vesicle prostaglandin synthetase, respectively. FPL 62064 has potent anti-inflammatory activity.
- GC4037112(S)-HEPECAS: 116180-17-7纯度: >98.00%
An anti-inflammatory monohydroxy fatty acid derived from EPA
- GC4044812(S)-HETECAS: 54397-83-0纯度: >98.00%
The predominant lipoxygenase product of mammalian platelets
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC38000 | β-Boswellic acid | 631-69-6 | >98.50% | |
A pentacyclic triterpene with diverse bioactivities | ||||
| GC39013 | FPL 62064 | 103141-09-9 | >98.00% | |
FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and prostaglandin synthetase (cyclooxygenase, COX) with IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and seminal vesicle prostaglandin synthetase, respectively. FPL 62064 has potent anti-inflammatory activity. | ||||
| GC40029 | 9(S),10(S),13(S)-TriHOME | 135214-44-7 | >98.00% | |
An oxylipin | ||||
| GC40278 | Leukotriene B3 | 88099-35-8 | >97.00% | |
The LTA hydrolase metabolite of LTA 3 | ||||
| GC40339 | Hepoxilin A3 methyl ester | - | >98.00% | |
A metabolite of arachidonic acid | ||||
| GC40349 | 12(S)-HETE-19,20-alkyne | - | >97.00% | |
A probe for 12(S)-HETE activity | ||||
| GC40357 | 9(S)-HpODE | 29774-12-7 | >98.00% | |
A 5-LO product derived from linoleic acid | ||||
| GC40368 | 11(R)-HEPE | 109430-11-7 | >98.00% | |
Produced by the oxidation of EPA by 11(R)-LO | ||||
| GC40371 | 12(S)-HEPE | 116180-17-7 | >98.00% | |
An anti-inflammatory monohydroxy fatty acid derived from EPA | ||||
| GC40372 | 12-OxoETE | 108437-64-5 | >90.00% | |
A 12-oxo derivative of arachidonic acid | ||||
| GC40373 | 15(S)-HEPE | 86282-92-0 | >98.00% | |
A monohydroxy fatty acid derived from EPA | ||||
| GC40376 | 15-OxoETE | 81416-72-0 | >98.00% | |
An oxylipin produced by oxidation of the 15-hydroxyl of 15-HETE | ||||
| GC40378 | 5(S)-HEPE | 92008-51-0 | >98.00% | |
A fatty acid produced by 5-LO oxidation of EPA | ||||
| GC40380 | 5-OxoETE | 106154-18-1 | >95.00% | |
A polyunsaturated keto acid?that stimulates neutrophil migration | ||||
| GC40382 | 8(S)-HEPE | 118492-81-2 | >98.00% | |
A monohydroxy fatty acid produced by lipoxygenase oxidation of EPA | ||||
| GC40383 | 9(S)-HEPE | 141545-44-0 | >98.00% | |
A monohydroxy fatty acid derived from EPA | ||||
| GC40427 | 15(S)-HEDE | 92693-04-4 | >98.00% | |
Isolated by the chromatographic resolution of (±)15-HEDE | ||||
| GC40445 | 11(R)-HETE | 73347-43-0 | >98.00% | |
An oxylipin | ||||
| GC40447 | 12(R)-HETE | 82337-46-0 | >98.00% | |
An active metabolite of arachidonic acid | ||||
| GC40448 | 12(S)-HETE | 54397-83-0 | >98.00% | |
The predominant lipoxygenase product of mammalian platelets | ||||
| GC40451 | 15(S)-HETE | 54845-95-3 | >98.00% | |
An active metabolite of arachidonic acid | ||||
| GC40459 | 5(R)-HETE | 61641-47-2 | >98.00% | |
A rare lipoxygenase product of arachidonic acid | ||||
| GC40462 | 8(R)-HETE | 105500-09-2 | >98.00% | |
A product of lipoxygenation of arachidonic acid in marine invertebrates | ||||
| GC40463 | 8(S)-HETE | 98462-03-4 | >98.00% | |
A PKC and PPARα activator | ||||