GlpBio

Lipoxygenase

Lipoxygenase(脂氧合酶)

Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.

Lipoxygenase 相关产品(254)

  • GC30277 structure
    GC302774',5-Dihydroxyflavone
    CAS: 6665-67-4

    4',5-Dihydroxyflavone inhibits soybean LOX-1 and yeast α-glucosidase.

  • GC30610 structure
    GC30610LY 178002
    CAS: 107889-32-7

    LY178002是一种有效的5-lipoxygenase，phospholipaseA2抑制剂，对5-lipoxygenase的IC50值为0.6μM，能够抑制人多形核白细胞产生LTB4，同时可相对较弱地抑制cyclooxygenase的活性。

  • GC31235 structure
    GC31235Cirsiliol
    CAS: 34334-69-5

    A flavonoid with diverse biological activities

  • GC31707 structure
    GC31707Chebulagic acid
    CAS: 23094-71-5
    纯度: >98.00%

    A polyphenol with diverse biological activities

  • GC31801 structure
    GC31801Enazadrem
    CAS: 107361-33-1

    Enazadrem是有效的5-脂氧合酶(5-lipoxygenase)抑制剂，具有抗炎功效。

  • GC31813 structure
    GC31813RWJ 63556
    CAS: 190967-35-2

    RWJ63556是一种可口服的COX-2selective/5-lipoxygenase抑制剂，具有抗炎活性。

  • GC31835 structure
    GC31835S-2474
    CAS: 158089-95-3

    S-2474是COX-2和5-lipoxygenase的抑制剂，在人完整的细胞中，对COX-2和COX-1的IC50值分别为11nM和27μM，为一种非甾体抗炎药。

  • GC31938 structure
    GC31938A-69412
    CAS: 123606-23-5

    A-69412是一种特异性的、亲水性5-脂氧合酶(5-LO)的可逆抑制剂。

  • GC31940 structure
    GC31940Docebenone (AA 861)
    CAS: 80809-81-0
    纯度: >99.00%

    A 5-LO inhibitor

  • GC31947 structure
    GC31947ICI 211965 (ZM-211965)
    CAS: 129424-08-4

    ICI 211965 (ZM-211965) (ZM-211965) 是一种选择性和口服有效的 5-脂氧合酶 (5-LPO) 抑制剂。

  • GC31961 structure
    GC31961CMI977 (LDP977)
    CAS: 175212-04-1

    CMI977 (LDP977) 是一种有效的 5-脂氧合酶 (5-LO) 抑制剂。

  • GC31967 structure
    GC31967COX/5-LO-IN-1
    CAS: 154355-75-6

    COX/5-LO-IN-1是cylooxygenase和5-lipoxygenase的抑制剂，用于炎症性和过敏性疾病的研究。

  • GC31978 structure
    GC31978Lonapalene (RS4317)
    CAS: 91431-42-4
    纯度: >99.00%

    Lonapalene (RS4317) (RS4317) 是一种局部有效的 5-脂氧合酶 (5-LO) 抑制剂。

  • GC31997 structure
    GC319975-Lipoxygenase-In-1
    CAS: 125235-15-6

    5-Lipoxygenase-In-1是5-脂氧合酶抑制剂，来自专利EP331232A2，table4，化合物实例4.10。

  • GC32002 structure
    GC32002Bunaprolast (U66858)
    CAS: 99107-52-5

    Bunaprolast (U66858) (U66858) 是人类全血中产生 LTB4 的有效抑制剂。

  • GC32035 structure
    GC32035AZD 4407 (ZD 4407)
    CAS: 166882-70-8

    AZD 4407 (ZD 4407) 是一种有效的 5-脂氧合酶抑制剂。

  • GC32038 structure
    GC32038PGS-IN-1 (KME-4)
    CAS: 102271-49-8
    纯度: >99.50%

    PGS-IN-1 (KME-4) 是一种有效的前列腺素合成酶 (PGS) 抑制剂，IC50 为 0.28 μM;也抑制 5-脂氧合酶，IC50 为 1.05 μM.

  • GC33905 structure
    GC33905CMI-392
    CAS: 205654-37-1

    CMI-392是一种双重5-lipoxygenese抑制剂和血小板活化因子(PAF)受体拮抗剂，IC50值分别为100和10nM。

  • GC33907 structure
    GC33907LP117
    CAS: 1056468-55-3

    LP117是一种新型且有效的5-脂氧合酶(5-LO)产品合成抑制剂，其IC50值为1.1μM。

  • GC35168 structure
    GC351685-O-Demethylnobiletin
    CAS: 2174-59-6
    纯度: >99.50%

    A flavonoid with diverse biological activities

  • GC35425 structure
    GC35425Atreleuton
    CAS: 154355-76-7

    A 5-LO inhibitor

  • GC36516 structure
    GC36516Lycopodine
    CAS: 466-61-5

    Lycopodine，一种石松 (Lycopodium clavatumspores) 孢子重要的生物活性成分，通过调节难治性前列腺癌细胞中 5-脂氧合酶 (5-lipoxygenase)，极化线粒体膜电位而不调节 p53 活性来诱导细胞凋亡。 Lycopodine 通过激活 caspase-3 诱导细胞凋亡来抑制 HeLa 细胞的增殖。

  • GC36628 structure
    GC36628ML355
    CAS: 1532593-30-8
    纯度: >98.00%

    A selective 12-LO inhibitor

  • GC36883 structure
    GC36883PF-4191834
    CAS: 1029317-21-2
    纯度: >98.00%

    PF-4191834 (PF-04191834) 是一种具有口服活性的，非铁螯合的，非氧化还原的 5-脂氧合酶 (5-LOX) 抑制剂(IC50=229 nM)，PF-4191834 对 5-LOX 的选择性约是 12-LOX 和 15-LOX 的 300 倍，对环氧合酶没有活性，对炎症和疼痛有效。