Lipoxygenase(脂氧合酶)

Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.

Products for Lipoxygenase

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Cat.No. 产品名称 Information
GC41150 14,15-Leukotriene E4

Eoxin E4, EXE4, 14,15LTE4
A metabolite of 14,15-LTC₄ with pro-inflammatory activity
GC41415 15(R)-Lipoxin A4

AT-Lipoxin A4
An aspirin-triggered lipoxin
GC40427 15(S)-HEDE Isolated by the chromatographic resolution of (±)15-HEDE
GC40373 15(S)-HEPE

15S-hydroxy-Eicosapentaenoic Acid
A monohydroxy fatty acid derived from EPA
GC46441 15(S)-HEPE-d5

15S-Hydroxyeicosapentaenoic Acid-d5
A neuropeptide with diverse biological activities
GC40451 15(S)-HETE

15(S)-Hydroxyeicosatetraenoic Acid
An active metabolite of arachidonic acid
GC41925 15(S)-HETE Ethanolamide

15(S)-HAEA, 15(S)-Hydroxyeicosatetraenoic Acid Ethanolamide
A CB₁ receptor ligand and FAAH inhibitor
GC40839 15(S)-HETE methyl ester

15(S)-Hydroxyeicosatetraenoic Acid methyl ester
A synthetic derivative of 15(S)-HETE
GC41926 15(S)-HETE-biotin

15(S)-Hydroxyeicosatetraenoic Acid-biotin
Used to detect 15(S)-HETE binding proteins and/or receptors
GC46442 15(S)-HETE-d8

15(S)-Hydroxyeicosatetraenoic Acid-d8
An internal standard for the quantification of 15(S)-HETE
GC49894 15(S)-HETE-d8 ethyl ester

15(S)-Hydroxyeicosatetraenoic Acid-d8 ethyl ester
An internal standard for the quantification of 15(S)-HETE ethyl ester
GC41927 15(S)-HETrE A 5-LO inhibitor
GC41403 15(S)-HpEDE A 15-LO product derived from eicosadienoic acid
GC41101 15(S)-HpEPE Produced by the action of 15-lipoxygenase on EPA
GC41124 15(S)-HpETE

15-羟基二十碳-5Z,8Z,11Z,13E-四烯酸
A product of 15-LO metabolism of arachidonic acid
GC41938 15-Lipoxygenase Inhibitor 1

15LO Inhibitor 1
An inhibitor of 15-LO
GC41940 15-OxoEDE

15KEDE
A PUFA produced by oxidation of 15-HEDE
GC40376 15-OxoETE

15KETE
An oxylipin produced by oxidation of the 15-hydroxyl of 15-HETE
GC41951 17(R)-Resolvin D1

Aspirin-triggered Resolvin D1
An aspirin-triggered epimer of RvD1
GC41227 17(R)-Resolvin D1 methyl ester

AspirintriggeredResolvin D1 methyl ester, ATRvD1 methyl ester, 17epiResolvin D1 methyl ester, 17(R)RvD1 methyl ester
Methyl ester of an aspirin-triggered resolvin
GC46457 17(R)-Resolvin D1-d5

Aspirin-triggered Resolvin D1-d5, 17-epi-Resolvin D1-d5, AT-RvD1-d5, 17(R)-RvD1-d5
A neuropeptide with diverse biological activities
GC41952 17(R)-Resolvin D4

4(S),5(R),17(R)-trihydroxy-DHA, 17(R)-RvD4
An aspirin-triggered epimer of RvD4
GC41208 17(S)-HDHA

17(S)hydroxy Docosahexaenoic Acid, 17(S)HDoHE
An oxidation product of DHA
GC46048 17(S)-HDHA-d5

17(S)-Hydroxy docosahexaenoic acid-d5, 17(S)-HDoHE-d5
A neuropeptide with diverse biological activities
GC49356 17(S)-HDoTE

17(S)-HDTA, 17(S)-hydroxy Docosatetraenoic Acid
A metabolite of adrenic acid
GC40975 17(S)-HpDHA

17(S)hydroperoxy Docosahexaenoic Acid, 17(S)HpDoHE
A mono-oxygenation product of DHA
GC41529 17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid

EFOX, 17oxo4(Z),7(Z),10(Z),13(Z),15(E),19(Z)DHA, 17-oxo-DHA
A metabolite of DHA with anti-inflammatory properties
GC41209 17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid

EFOX, 17-oxo-DPA, 17oxo7(Z),10(Z),13(Z),15(E),19(Z)DPA
A metabolite of DPA with anti-inflammatory properties
GC41980 18-carboxy dinor Leukotriene B4

18carboxy dinor LTB4
β-oxidation metabolite of LTB₄
GC46057 2,5-Dihydroxycinnamic Acid phenethyl ester An inhibitor of 5-LO
GC42082 20-carboxy Leukotriene B4

20-羧基白三烯B4
A LTB₄ metabolite
GC41421 20-hydroxy Leukotriene B4

20-羟基白三烯B4
A LTB₄ metabolite
GC49849 3-Aminosalicylic Acid

3-氨基水杨酸
A salicylic acid derivative
GC49364 3-Hydroxycoumarin

3-羟基香豆素
A coumarin with diverse biological activities
GC64078 3-O-Acetyl-11-hydroxy-beta-boswellic acid

3α-O-乙酰基-11α-羟基-β-乳香酸
3-O-Acetyl-11-hydroxy-beta-boswellic acid 是一种5-脂氧合酶 (5-LO) 抑制剂。
GC30277 4',5-Dihydroxyflavone

5,4'-二羟基黄酮
4',5-Dihydroxyflavone inhibits soybean LOX-1 and yeast α-glucosidase.
GC45931 4(S),11(R)-DiHDoHE A neuropeptide with diverse biological activities
GC64621 4-Nitrocatechol

4-硝基儿茶酚
4-Nitrocatechol 是一种有效的脂氧合酶 (lipoxygenase) 抑制剂。
GC40459 5(R)-HETE

5(R)-Hydroxyeicosatetraenoic Acid
A rare lipoxygenase product of arachidonic acid
GC41126 5(S),12(S)-DiHETE A natural bioactive lipid
GC41127 5(S),15(S)-DiHETE A dihydroxy fatty acid synthesized by 15-LO from 5(S)-HETE
GC41128 5(S),6(R)-11-trans DiHETE A metabolite of LTA₄
GC41129 5(S),6(R)-DiHETE A dihydroxy hydrolysis product of LTA₄
GC41131 5(S),6(S)-DiHETE A hydrolysis product of LTA₄
GC40378 5(S)-HEPE A fatty acid produced by 5-LO oxidation of EPA
GC40460 5(S)-HETE

5(S)-Hydroxyeicosatetraenoic Acid
A 5-LO metabolite of arachidonic acid
GC40829 5(S)-HETE lactone

5(S)-Hydroxyeicosatetraenoic Acid lactone
A potential 5-LO inhibitor
GC46679 5(S)-HETE-d8

5(S)-Hydroxyeicosatetraenoic Acid-d8
An internal standard for the quantification of 5-HETE
GC42479 5(S)-HETrE A monohydroxy fatty acid synthesized by 5-LO from mead acid
GC41105 5(S)-HpEPE Produced by the action of 5-LO on EPA; LTA₅ precursor