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Home >> Signaling Pathways >> Proteases >> Lipoxygenase

Lipoxygenase(脂氧合酶)

Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.

Products for  Lipoxygenase

  1. Cat.No. 产品名称 Information
  2. GC47574 Loratadine-d4

    Loratidine-d4; SCH 29851-d4

     A neuropeptide with diverse biological activities
  3. GC47575 Loratadine-d5

    五氘代氯雷他定,Loratidine-d5; SCH 29851-d5

     An internal standard for the quantification of loratadine
  4. GC33907 LP117 LP117是一种新型且有效的5-脂氧合酶(5-LO)产品合成抑制剂，其IC50值为1.1μM。
  5. GC30610 LY 178002

    LY178002是一种有效的5-lipoxygenase，phospholipaseA2抑制剂，对5-lipoxygenase的IC50值为0.6μM，能够抑制人多形核白细胞产生LTB4，同时可相对较弱地抑制cyclooxygenase的活性。
  6. GC36516 Lycopodine

    石松鹼

     Lycopodine，一种石松 (Lycopodium clavatumspores) 孢子重要的生物活性成分，通过调节难治性前列腺癌细胞中 5-脂氧合酶 (5-lipoxygenase)，极化线粒体膜电位而不调节 p53 活性来诱导细胞凋亡。 Lycopodine 通过激活 caspase-3 诱导细胞凋亡来抑制 HeLa 细胞的增殖。
  7. GC91594 LYS-006 (hydrochloride) LYS-006 is an inhibitor of leukotriene A4 (LTA4) hydrolase.
  8. GC14751 Malotilate

    马洛替酯; NKK 105

     A hepatoprotective agent
  9. GC47598 Maresin 1-d5

    7(R)-MaR1-d5, 7(R)-Maresin 1-d5

     A neuropeptide with diverse biological activities
  10. GC40980 Maresin 2

    3R,14S-diHDHA

     A 13R,14S-dihydroxy DHA produced by macrophages
  11. GC47599 Maresin 2-d5

    13R,14S-diHDHA-d5, 13R,14S-dihydroxy Docosahexaenoic Acid-d5, MaR2-d5

     A neuropeptide with diverse biological activities
  12. GC69434 Masoprocol

    meso-Nordihydroguaiaretic acid; meso-NDGA

     Masoprocol (meso-Nordihydroguaiaretic acid) 是一种有效且具有口服活性的脂氧合酶 (lipoxygenase) 抑制剂。Masoprocol 显示出抗高血糖活性。 Masoprocol 降低体内葡萄糖浓度和肝脏甘油三酯浓度。Masoprocol具有研究II型糖尿病的潜力。
  13. GC44138 MCTR1

    13-glutathionyl-14-hydroxy Docosahexaenoic Acid, Maresin Conjugates in Tissue Regeneration 1, Maresin Sulfido Conjugate 1

     A specialized pro-resolving mediator
  14. GC44139 MCTR2

    13-cysteinylglycinyl-14-hydroxy Docosahexaenoic Acid, Maresin Conjugates in Tissue Regeneration 2, Maresin Sulfido Conjugate 2

     A specialized pro-resolving mediator
  15. GC44140 MCTR3

    13-cysteinyl14-hydroxyDocosahexaenoic Acid, Maresin Conjugates in Tissue Regeneration 3, Maresin Sulfido Conjugate 3

     A specialized pro-resolving mediator
  16. GC74159 MK-0731 MK-0731是一种选择性、非竞争性和变构驱动蛋白纺锤体蛋白（KSP）抑制剂，IC50为2.2 nM，pKa为7.6。
  17. GC44212 MK-886 (sodium salt) A potent, selective inhibitor of 5-lipoxygenase-activating protein (FLAP)
  18. GC36628 ML355 A selective 12-LO inhibitor
  19. GC70448 MLS000545091 MLS000545091是一种有效的选择性脂氧合酶-2（LOX-2）抑制剂，对h15-LOX-2的IC50值为2.6μM。
  20. GC52105 Montelukast

    孟鲁司特,MK0476 free base

     A CysLT1 receptor antagonist
  21. GC47701 Montelukast-d6 (sodium salt)

    MK-476-d6

     A neuropeptide with diverse biological activities
  22. GC47716 Myxochelin A

    (S)-Myxochelin A

     A microbial metabolite with diverse biological activities
  23. GC44295 N-acetyl Leukotriene E4

    Nacetyl LTE4

     The major inactive metabolite of LTE4 found in bile
  24. GC44415 N-methyl Leukotriene C4

    Nmethyl LTC4

    A stable LTC4 mimetic
  25. GC18089 Nordihydroguaiaretic acid

    去甲二氢愈创木酸; NDGA

     A non-selective LO inhibitor
  26. GC49098 Olsalazine-13C6 An internal standard for the quantification of olsalazine
  27. GC44579 PCTR1

    Protein Conjugates in Tissue Regeneration 1

     A specialized pro-resolving mediator
  28. GC44580 PCTR2

    Protein Conjugates in Tissue Regeneration 2

     A specialized pro-resolving mediator
  29. GC44581 PCTR3

    Protein Conjugates in Tissue Regeneration 3

     A specialized pro-resolving mediator
  30. GC36883 PF-4191834

    PF-04191834

    PF-4191834 (PF-04191834) 是一种具有口服活性的，非铁螯合的，非氧化还原的 5-脂氧合酶 (5-LOX) 抑制剂(IC50=229 nM)，PF-4191834 对 5-LOX 的选择性约是 12-LOX 和 15-LOX 的 300 倍，对环氧合酶没有活性，对炎症和疼痛有效。
  31. GC32038 PGS-IN-1 (KME-4)

    KME-4

     PGS-IN-1 (KME-4) 是一种有效的前列腺素合成酶 (PGS) 抑制剂，IC50 为 0.28 μM;也抑制 5-脂氧合酶，IC50 为 1.05 μM.
  32. GC61180 Phenidone

    菲尼酮

     Phenidone (1-phenyl-3-pyrazolidinone), a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), is an organic compound that is primarily used as a photographic developer.
  33. GC45768 Pranlukast-d4

    ONO-1078-d4

     A neuropeptide with diverse biological activities
  34. GC40981 Protectin D1

    保护素D1,Neuroprotectin D1; NPD1

    A specialized pro-resolving mediator
  35. GC48993 Protectin D1-d5

    Neuroprotectin D1-d5, NPD1-d5, PD1-d5

     An internal standard for the quantification of protectin D1
  36. GC14847 Psoralidin

    补骨脂定

     A furanocoumarin with anti-cancer activity
  37. GC48035 RCTR1

    Resolvin Glutathione Conjugate in Tissue Regeneration 1, Resolvin Sulfido Conjugate 1

     A specialized pro-resolving mediator
  38. GC41230 Resolvin D1 methyl ester

    RvD1 methyl ester

     Derivative of resolvin D1
  39. GC48041 Resolvin D1-d5

    RvD1-d5

     An internal standard for the quantification of RvD1
  40. GC41231 Resolvin D2 methyl ester

    7(S),16(R),17(S)Resolvin D2 methyl ester, RvD2 methyl ester

     Methyl ester form of RvD2
  41. GC48042 Resolvin D2-d5

    RvD2-d5

     An internal standard for the quantification of RvD2
  42. GC41232 Resolvin D3 methyl ester

    RvD3 methyl ester

     A methyl ester form of resolvin D3
  43. GC48043 Resolvin D3-d5

    RvD3-d5

     A neuropeptide with diverse biological activities
  44. GC44818 Resolvin D4

    RvD4

     A pro-resolving mediator
  45. GC40982 Resolvin D5

    7(S),17(S)-diHDHA

     A potent anti-inflammatory, pro-resolving lipid mediator
  46. GC48044 Resolvin E1-d4

    RvE1d4, 5S,12R,18R-trihydroxy-EPA-d4, 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-EPA-d4, 5,12,18R-triHEPE-d4

     A neuropeptide with diverse biological activities
  47. GC48972 Resolvin E2

    (-)-Resolvin E2

     A specialized pro-resolving mediator
  48. GC48045 Resolvin E4

    RvE4

     A specialized pro-resolving mediator
  49. GC41189 Ricinelaidic Acid An LTB4 antagonist
  50. GC31813 RWJ 63556 RWJ63556是一种可口服的COX-2selective/5-lipoxygenase抑制剂，具有抗炎活性。
  51. GC30027 S-(+)-Marmesin ((+)-Marmesin)

    异紫花前胡内酯,(+)-Marmesin; (S)-Marmesin

     A coumarin with anticancer activity

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