Leukotriene A4 (LTA4) is synthesized in mast cells, eosinophils, and neutrophils from arachidonic acid by 5-lipoxygenase (5-LO), which exhibits both lipoxygenase and LTA4 synthase activities. LTA4 is rapidly metabolized by LTA4 hydrolase or LTC4 synthase to LTB4 or LTC4, respectively. LTA4, from leukocytes, is known to undergo transcellular metabolism in platelets, erythrocytes, and endothelial cells. Further metabolism of LTA4 by 15-LO leads to lipoxin biosynthesis. LTA4 as a free acid is highly unstable. The methyl ester is stable and can be readily hydrolyzed to the free acid as needed.
Leukotriene A4 methyl ester
目录号: GC18835纯度: >97.00%同义词: LTA4 methyl ester
A stable form of LTA4
Cas No.: 73466-12-3
| 规格 | 价格 | 库存 | 数量 | 操作 |
|---|---|---|---|---|
| 25μg | ¥2,218.00 | 现货 | 1 | |
| 50μg | ¥4,220.00 | 现货 | 1 | |
| 100μg | ¥7,993.00 | 现货 | 1 |
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Nature628, 630–638 (2024)
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Nature618, 1017–1023 (2023)
Nature610, 366–372 (2022)
Cell187(9):2288-2304 (2024)
Cell183(7):1867-1883 (2020)
Science388(6745) (2025)
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Cell Research35, 97–116 (2025)
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产品描述 Description
产品文档 Product Documents
Purity:>97.00%
化学性质Chemical Properties
CAS 号
73466-12-3
同义词
LTA4 methyl ester
化学名
5S-trans-5,6-oxido-7E,9E,11Z,14Z-eicosatetraenoic acid, methyl ester
SMILES
CCCCC/C=C\C/C=C\C=C\C=C\[C@H](O1)[C@@H]1CCCC(OC)=O
分子式
C21H32O3
分子量
332.5 g/mol
溶解性
Acetone: >50 mg/ml,DMF: >50 mg/ml,DMSO: >50 mg/ml,Ethanol: >50 mg/ml,PBS pH 7.2: insoluble and unstable.
保存条件
Store at -80°C; protect from light
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。
计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度
g/mol