GlpBio

E1/E2/E3 Enzyme

E1/E2/E3 Enzyme(E1/E2/E3泛素酶)

Ubiquitin (UB) is a protein modifier that regulates many essential cellular processes. To initiate protein modification by UB, the E1 enzyme activates the C-terminal carboxylate of UB to launch its transfer through the E1-E2-E3 cascade onto target proteins. The E1 enzyme is the activating enzyme, to which ubiquitin is attached in an ATP-dependent reaction by a thioester bond. The E2 enzyme is the conjugating enzyme, to which the ubiquitin is transferred from the E1. The E3 is the ubiquitin ligase, which directly or indirectly catalyzes the transfer of the ubiquitin to the target protein (the substrate), with the formation of an isopeptide bond.

E1/E2/E3 Enzyme 相关产品(92)

  • GC10134 structure
    GC10134Ginkgolic Acid C15:1
    CAS: 22910-60-7
    纯度: >98.00%

    An inhibitor of SUMOylation

  • GC10408 structure
    GC104082-D08
    CAS: 144707-18-6
    纯度: >98.00%

    2-D08是一种合成黄酮和具有细胞通透性的小泛素样修饰蛋白（SUMO）抑制剂，也能抑制Axl靶点，IC 50 为0.49nM。

  • GC10470 structure
    GC10470Nutlin-3a chiral
    CAS: 675576-98-4
    纯度: >98.00%

    Nutlin-3a 手性是 Nutlin-3 的活性异构体，是鼠类双微体 2 (MDM2) 拮抗剂，IC50 值为 0.09μM。

  • GC10940 structure
    GC10940PRT 4165
    CAS: 31083-55-3
    纯度: >98.50%

    An inhibitor of PRC1 ubiquitin ligases

  • GC11445 structure
    GC11445YH239-EE
    CAS: 1364488-67-4
    纯度: >99.50%

    A prodrug form of YH 239

  • GC11547 structure
    GC11547MI-773 (SAR405838)
    CAS: 1303607-60-4
    纯度: >95.00% / >98.00%

    An inhibitor of MDM2-p53 protein-protein interactions

  • GC11594 structure
    GC11594RG7388
    CAS: 1229705-06-9
    纯度: >99.50%

    RG7388是一种具有口服活性的MDM2（IC 50 =6nM）拮抗剂，RG7388通过抑制MDM2-p53相互作用来激活p53通路。

  • GC11869 structure
    GC11869SZL P1-41
    CAS: 222716-34-9
    纯度: >98.00%

    SZL P1-41是一种特异性S期激酶相关蛋白2（Skp2）抑制剂。

  • GC12117 structure
    GC12117JNJ-26854165 (Serdemetan)
    CAS: 881202-45-5
    纯度: >99.00%

    An antagonist of MDM2 action

  • GC12508 structure
    GC12508Nutlin-3b
    CAS: 675576-97-3
    纯度: >98.00%

    The less active enantiomer of (–)-nutlin-3

  • GC12647 structure
    GC12647NVP-CGM097
    CAS: 1313363-54-0
    纯度: >98.50%

    An inhibitor of the MDM2-p53 interaction

  • GC13019 structure
    GC13019RG7112
    CAS: 939981-39-2
    纯度: >99.50%

    An inhibitor of the MDM2-p53 interaction

  • GC13590 structure
    GC13590SJ 172550
    CAS: 431979-47-4
    纯度: >98.00%

    A small molecule inhibitor of MDMX

  • GC15771 structure
    GC15771PYR-41
    CAS: 418805-02-4
    纯度: >98.00%

    PYR-41是一种不可逆的、细胞渗透性的泛素激活酶E1抑制剂，IC 50 值小于10μM，对E2和E3基本无作用。

  • GC15828 structure
    GC15828AMG232
    CAS: 1352066-68-2
    纯度: >98.00%

    An inhibitor of the MDM2 and p53 interaction

  • GC16051 structure
    GC16051Nutlin-3
    CAS: 890090-75-2
    纯度: >99.00% / >98.00%

    A racemic mixture of (?)-nutlin-3 and (+)-nutlin-3

  • GC16055 structure
    GC16055SMIP004
    CAS: 143360-00-3
    纯度: >98.50%

    SMIP004 是一种 SKP2 E3 连接酶抑制剂，可下调 SKP2 并稳定 p27。 SMIP004 是人前列腺癌细胞的癌细胞选择性凋亡诱导剂。

  • GC16296 structure
    GC16296MI-773
    CAS: 1303607-07-9
    纯度: >98.00%

    MI-773 是一种有效的 MDM2-p53 蛋白-蛋白相互作用 (PPI) 抑制剂，对 MDM2 具有高结合亲和力 (Kd=8.2 nM)。 MI-773 具有抗肿瘤活性。

  • GC16368 structure
    GC16368Indole-3-carbinol
    CAS: 700-06-1
    纯度: >98.00%

    A natural phytochemical

  • GC16371 structure
    GC16371Solasodine
    CAS: 126-17-0
    纯度: >98.00%

    An alkaloid with diverse biological activities

  • GC17801 structure
    GC17801PYZD-4409
    CAS: 423148-78-1
    纯度: >98.00%

    PYZD-4409 是泛素激活酶 UBA1 的特异性抑制剂，IC50 为 20 μM（无细胞酶测定）。 PYZD-4409 在恶性细胞中诱导细胞死亡并优先抑制原发性急性髓细胞白血病细胞的克隆形成。

  • GC18136 structure
    GC18136BH3I-1
    CAS: 300817-68-9
    纯度: >98.00%

    An inhibitor of anti-apoptotic Bcl-2 proteins

  • GC18561 structure
    GC18561TZ9
    CAS: 1002789-86-7
    纯度: >99.50%

    A Rad6B inhibitor

  • GC19088 structure
    GC19088CC122
    CAS: 1015474-32-4
    纯度: >99.50%

    A pleiotropic pathway modifier with anticancer activity