GlpBio

Glutathione Peroxidase

Glutathione Peroxidase(谷胱甘肽过氧化物酶)

Glutathione Peroxidase (GPx) is the general name of an enzyme family with peroxidase activity whose main biological role is to protect the organism from oxidative damage. Glutathione peroxidase functions to reduce lipid hydroperoxides to their corresponding alcohols and to reduce free hydrogen peroxide to water.

Glutathione peroxidase plays a role in the development of celiac disease. Several isozymes glutathione peroxidase are encoded by different genes, which vary in cellular location and substrate specificity. Glutathione peroxidase 1 (GPx1) is the most abundant version, existing in the cytoplasm of nearly all mammalian tissues, whose preferred substrate is hydrogen peroxide. Glutathione peroxidase 4 (GPx4) has a high preference for lipid hydroperoxides; it is expressed in almost all the mammalian cells, though at much lower levels. Glutathione peroxidase 2 is an intestinal and extracellular enzyme, while glutathione peroxidase 3 is extracellular, especially abundant in plasma. So far, eight different isoforms of glutathione peroxidase (GPx1-8) have been identified in humans.

Glutathione Peroxidase 相关产品(34)

  • GC12431 structure
    GC12431RSL3
    CAS: 1219810-16-8
    纯度: >98.00%

    RSL3被认为是一种强效的诱导铁死亡剂，其作用依赖于GPX4的活性。

  • GC18256 structure
    GC18256PF-06281355
    CAS: 1435467-38-1
    纯度: >99.50%

    A myeloperoxidase inhibitor

  • GC18705 structure
    GC18705ML-210
    CAS: 1360705-96-9
    纯度: >99.50% / >98.00%

    ML-210是一种前体药物，能够选择性共价抑制GPX4，EC 50 值为30nM。

  • GC19285 structure
    GC19285PF-06282999
    CAS: 1435467-37-0
    纯度: >99.00%

    A myeloperoxidase inhibitor

  • GC19706 structure
    GC19706Propacetamol hydrochloride
    CAS: 66532-86-3

    A prodrug form of acetaminophen

  • GC20109 structure
    GC20109Cefotiam hexetil hydrochloride
    CAS: 95789-30-3

    Cefotiam hexetil hydrochloride 是可口服的第三代头孢菌素，是 cefotiam 的前药，但无抗菌作用。Cefotiam 是一种抗生素。

  • GC30237 structure
    GC30237Verdiperstat (AZD3241)
    CAS: 890655-80-8
    纯度: >99.50%

    Verdiperstat (AZD3241, BHV-3241) is a selective, orally active and irreversible inhibitor of myeloperoxidase (MPO) with IC50 of 630 nM. Verdiperstat (AZD3241) can be used in the research of neurodegenerative brain disorders.

  • GC30783 structure
    GC30783AZD5904
    CAS: 618913-30-7
    纯度: >99.50%

    A myeloperoxidase inhibitor

  • GC31882 structure
    GC31882Tinoridine hydrochloride (Y-3642 hydrochloride)
    CAS: 25913-34-2
    纯度: >98.00%

    Tinoridine hydrochloride (Y-3642) is a non-steroidal anti-inflammatory drug with a potent antiperoxidative activity.

  • GC35139 structure
    GC351394-Methylesculetin
    CAS: 529-84-0
    纯度: >95.00%

    4-methylesculetin is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase (MPO) activity and reduces IL-6 level.

  • GC36650 structure
    GC36650MPO-IN-28
    CAS: 37836-90-1
    纯度: >98.00%

    MPO-IN-28 (Compound 28) is an inhibitor of myeloperoxidase (MPO) with IC50 of 44 nM.

  • GC40555 structure
    GC40555Tiopronin
    CAS: 1953-02-2
    纯度: >98.00%

    Tiopronin is an antioxidant that has diverse biological activities.

  • GC41151 structure
    GC41151Decursinol angelate
    CAS: 130848-06-5
    纯度: >98.00%

    Decursinol angelate is a pyranocoumarin that has been found in the Korean medicinal herb A.

  • GC60263 structure
    GC60263N-Acetyl lysyltyrosylcysteine amide
    CAS: 1287585-40-3

    N-Acetyllysyltyrosylcysteineamide是一种有效的，可逆的，特异性且无毒的髓过氧化物酶(MPO)三肽抑制剂。N-Acetyllysyltyrosylcysteineamide在体内可有效抑制MPO产生有毒氧化剂。N-Acetyllysyltyrosylcysteineamide减轻中风后大脑的神经元损伤，并保留脑组织和神经功能。N-Acetyllysyltyrosylcysteineamide抑制MPO依赖性次氯酸(HOCl)的生成，蛋白质硝化和LDL氧化。

  • GC63729 structure
    GC63729GPX4-IN-3
    CAS: 2761004-85-5
    纯度: >99.50%

    GPX4-IN-3 (26a) 是有效的谷胱甘肽过氧化物酶4 (GPX4) 抑制剂，可选择性诱导铁死亡 (ferroptosis)。GPX4-IN-3 (26a) 在1 μM 的浓度可抑制GPX4 71.7% 活性。

  • GC63975 structure
    GC63975Acanthoside B
    CAS: 7374-79-0

    Acanthoside B 是一种具有抗炎、抗遗忘活性的生物活性木脂素。Acanthoside B 可用于阿尔茨海默病和肺部炎症等疾病的研究。

  • GC64119 structure
    GC64119Saponarin
    CAS: 20310-89-8

    A flavonoid glycoside with diverse biological activities

  • GC67918 structure
    GC67918MPO-IN-1
    CAS: 2471981-21-0

    MPO-IN-1 是一种有效的, 具有口服活性的，不可逆的含有吲哚结构的髓过氧化物酶 (MPO) 抑制剂，对 MPO 和甲状腺过氧化物 (TPO) 的 IC50 值分别为 2.6 μM 和 5.3 μM。MPO-IN-1 在急性炎症小鼠模型中抑制 MPO 活性。

  • GC68468 structure
    GC68468MPO-IN-3
    CAS: 1435469-45-6

    MPO-IN-3 是一种有效的 myeloperoxidase 抑制剂 (WO2013068875A1, example 191)。髓过氧化物酶 (MPO) 是一种含血红素的酶，属于过氧化物酶超家族。

  • GC69468 structure
    GC69468Mitiperstat
    CAS: 1933460-19-5
    纯度: >97.00%

    Mitiperstat (AZD4831) 是髓过氧化物酶 (MPO) 的有效抑制剂。Mitiperstat 在预防心血管疾病 (例如心力衰竭和冠状动脉疾病相关疾病) 的研究中特别有用 (信息提取自专利 US20160152623A1)。

  • GC71917 structure
    GC71917Moracin N
    CAS: 135248-05-4
    纯度: >99.00%

    Moracin N是一种可以从桑叶中分离出来的铁中毒抑制剂。

  • GC72788 structure
    GC72788HLF1-11
    CAS: 183623-03-2
    纯度: >99.00%

    HLF1-11人乳铁蛋白衍生肽是一种广谱抗菌剂。

  • GC73066 structure
    GC73066GPX4-IN-2
    CAS: 2485005-22-7
    纯度: >98.00%

    GPX4-IN-2是一种强效的GPX4抑制剂。

  • GC73223 structure
    GC73223PROTAC GPX4 degrader-1
    CAS: 2916433-81-1
    纯度: >99.00%

    PROTAC GPX4 degrader-1 (DC-2)是一种基于protac的GPX4降解剂，在HT1080细胞中的DC50为0.03 μM。