GlpBio

Tyrosinases

Tyrosinases(酪氨酸酶)

Tyrosinase is an oxidase that is the rate-limiting enzyme for controlling the production of melanin. The enzyme is mainly involved in two distinct reactions of melanin synthesis. Tyrosinase is a copper-containing enzyme present in plant and animal tissues that catalyzes the production of melanin and other pigments from tyrosine by oxidation, as in the blackening of a peeled or sliced potato exposed to air. It is found inside melanosomes which are synthesised in the skin melanocytes. In humans, the tyrosinase enzyme is encoded by the TYR gene. Tyrosinase is one of the key enzymes in mammalian melanin synthesis.

Tyrosinases 相关产品(50)

  • GC13621 structure
    GC13621Hexylresorcinol
    CAS: 136-77-6
    纯度: >98.00%

    An alkylresorcinol

  • GC16079 structure
    GC16079Deoxyarbutin
    CAS: 53936-56-4
    纯度: >98.00%

    A tyrosinase inhibitor

  • GC19385 structure
    GC19385XMD16-5
    CAS: 1345098-78-3
    纯度: >98.50%

    A TNK2 inhibitor

  • GC19387 structure
    GC19387XMD8-87
    CAS: 1234480-46-6
    纯度: >98.50%

    A selective TNK2 inhibitor

  • GC25188 structure
    GC25188Calcium 2-oxoglutarate
    CAS: 71686-01-6

    Calcium 2-oxoglutarate (Calcium oxoglurate, Calcium 2-oxopentanedioate, Calcium α-ketoglutarate, Calcium AKG, Calcium 2-ketoglutaric acid, Calcium oxoglutaric acid) is the Calcium salt form of 2-oxoglutarate. 2-oxoglutarate is naturally found in organisms and is a well-known intermediate in the production of ATP or GTP in the Krebs cycle. 2-oxoglutarate is a reversible inhibitor of tyrosinase with IC50 of 15 mM.

  • GC30136 structure
    GC301362-Ketoglutaric acid
    CAS: 328-50-7

    2-Ketoglutaric acid是一种可逆的酪氨酸酶抑制剂，IC 50 值为15 ± 0.5mM。

  • GC30513 structure
    GC305134-Butylresorcinol (Butylresorcinol)
    CAS: 18979-61-8
    纯度: >98.00%

    4-Butylresorcinol (4-n-Butylresorcinol, Rucinol) is a potent inhibitor of tyrosinase and is used in cosmetics as a depigmenting agent.

  • GC30564 structure
    GC305642-Hydroxy-4-methoxybenzaldehyde
    CAS: 673-22-3
    纯度: >99.50%

    A phenol with diverse biological activities

  • GC31549 structure
    GC31549Glycolic acid
    CAS: 79-14-1

    Glycolic acid (dicarbonous acid, hydroxyacetic acid, hydroacetic acid) is the smallest alpha-hydroxy acid. Due to its excellent capability to penetrate skin, glycolic acid is often used in skin care products, most often as a chemical peel. Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.

  • GC33464 structure
    GC33464Oxyresveratrol (trans-Oxyresveratrol)
    CAS: 29700-22-9
    纯度: >98.50%

    A resveratrol analog

  • GC35494 structure
    GC35494Benzoyloxypaeoniflorin
    CAS: 72896-40-3

    Benzoyloxypaeoniflorin 分离于 Paeonia suffruticosa 的根，是 tyrosinase 抑制剂，对蘑菇 tyrosinase 的 IC50为 0.453 mM。Benzoyloxypaeoniflorin 是 NF-κB 抑制剂，Benzoyloxypaeoniflorin 通过对血小板聚集和凝血的抑制作用，有助于改善血液循环。

  • GC35675 structure
    GC35675Chimonanthine
    CAS: 5545-89-1

    Chimonanthine 是腊梅中的生物碱，抑制酪氨酸酶及酪氨酸酶相关蛋白 1 mRNA 的表达，抑制黑色素的形成。

  • GC36144 structure
    GC36144Glabrene
    CAS: 60008-03-9

    Glabrene 是一种来源于甘草根的异黄酮，具有雌激素样活性。Glabrene 是 tyrosinase 抑制剂，IC50 值为 3.5 μM。

  • GC36402 structure
    GC36402Kushenol A
    CAS: 99217-63-7
    纯度: >99.50%

    Kushenol A 是从苦参 (Sophora flavescent) 的根中分离出来的，一种非竞争性酪氨酸酶 (tyrosinase) 抑制剂，IC50 和 Ki 值分别为 1.1 μM 和 0.4 μM。Kushenol A 是一种黄酮类抗氧化剂，对 α-葡萄糖苷酶 (alpha-glucosidase) 和 β-淀粉酶(beta-amylase)具有抑制作用。Kushenol A 被证实是可用于化妆品的针对皮肤美白和衰老的潜在物质。

  • GC36595 structure
    GC36595Methyl rosmarinate
    CAS: 99353-00-1
    纯度: >99.00%

    Methyl rosmarinate 是一种从 Rabdosia serra 中分离得到的非竞争性 tyrosinase 抑制剂，对蘑菇酪氨酸酶作用的 IC50 值为 0.28 mM，也能抑制 a-glucosidase[1]。

  • GC36663 structure
    GC36663Mulberroside F
    CAS: 193483-95-3

    Mulberroside F 是桑树 (Morus alba L.) 中的主要生物活性成分之一。Mulberroside F 抑制酪氨酸酶 (tyrosinase) 活性和黑色素形成。Mulberroside F 还具有超氧化物清除活性。

  • GC37707 structure
    GC37707Swertiajaponin
    CAS: 6980-25-2

    Swertiajaponin 是一种酪氨酸酶抑制剂，与酪氨酸酶结合囊形成多个氢键和疏水相互作用，IC50 值为 43.47 μM。Swertiajaponin 还能通过抑制氧化应激介导的 MAPK/MITF 信号导致酪氨酸酶蛋白水平下降。Swertiajaponin 能抑制黑色素积累，具有较强的抗氧化活性。

  • GC38166 structure
    GC38166Trifolirhizin
    CAS: 6807-83-6
    纯度: >99.50% / >98.50%

    A flavonoid with anticancer and vasorelaxant activities

  • GC38720 structure
    GC38720(R)-Trolox
    CAS: 53101-49-8
    纯度: >98.00%

    (R)-Trolox 是水溶性维生素 E 类似物，是一种竞争性酪氨酸酶抑制剂，Ki 值为 0.83 mM，ID50 值为 1.88 mM。(R)-Trolox 具有比 (S) 对映异构体更强的酪氨酸酶亲和力 (Ki 值为 0.61 mM)。

  • GC38815 structure
    GC38815Methyl cinnamate
    CAS: 103-26-4
    纯度: >99.00%

    Methyl cinnamate, an active component of Zanthoxylum armatum, is a widely used natural flavor compound with antimicrobial and tyrosinase inhibitor activities. Methyl Cinnamate Inhibits Adipocyte Differentiation via Activation of the CaMKK2--AMPK Pathway in 3T3-L1 Preadipocytes.

  • GC38818 structure
    GC38818Mirificin
    CAS: 103654-50-8

    Mirificin (Puerarin apioside) 是葛根中的异黄酮。Mirificin 抑制酪氨酸酶 (TYR)，IC50 为 12.66 μM。

  • GC39327 structure
    GC393273,4-Dimethoxyphenol
    CAS: 2033-89-8
    纯度: >96.00%

    3,4-Dimethoxyphenol 是植物来源的苯基丙烷化合物，可在化妆品中用作增白剂。3,4-Dimethoxyphenol 具有酪氨酸酶 (tyrosinase) 抑制活性。从细菌发酵液中分离出的 3,4-Dimethoxyphenol 具有有效的抗氧化作用。

  • GC40259 structure
    GC40259(±)-β-Tocopherol
    CAS: 148-03-8
    纯度: >99.50%

    A lipid-soluble form of vitamin E

  • GC40260 structure
    GC40260(±)-γ-Tocopherol
    CAS: 7616-22-0
    纯度: >95.00%

    A form of vitamin E