GlpBio

Caspase

Caspase(半胱天冬酶蛋白)

Caspases (cysteine-dependent aspartate specific ptotease) are a family of cysteine proteases that play an essential role in cell apoptosis. Caspases contain a conserved QACXG pentapeptide active site motif and are characterized by specificity for aspartic acid in the P1 position. The synthesis of caspases involves the activation of inactive proenzymes, which contain an N-terminal peptide (prodomain) together with two subunits (one small and one large), following cleavage at specific aspartate cleavage sites. Caspases can be classified into three subfamilies, due to phylogenetic analysis, including an ICE subfamily (caspases-1, -4 and -5), a CED-3/CPP32 subfamily (caspases-3, -6, -7, -8, -9 and -10) and an ICH-1/Nedd2 subfamily (caspase-2).

Caspase 相关产品(113)

  • GC12861 structure
    GC12861Z-VAD-FMK
    CAS: 187389-52-2
    纯度: >98.00% / >99.00%

    Z-VAD-FMK（苄氧羰基-Val-Ala-Asp（OMe）氟甲基酮），是一种类似ICE的蛋白酶抑制剂，通过阻止CPP32转化为其活性形式来抑制细胞凋亡。

  • GC16316 structure
    GC16316Q-VD-OPh hydrate
    CAS: 1135695-98-5
    纯度: >99.50% / >97.00%

    Q-VD-OPh hydrate是一种广谱、可渗透细胞、高效且无毒的caspase抑制剂，对重组caspase1,3,8和9的IC 50 值在25-400nM范围内。

  • GC10661 structure
    GC10661Destruxin B
    CAS: 2503-26-6

    An insecticidal mycotoxin

  • GC10978 structure
    GC10978Terfenadine
    CAS: 50679-08-8
    纯度: >98.00%

    A selective histamine H 1 -receptor antagonist

  • GC11988 structure
    GC1198815-acetoxy Scirpenol
    CAS: 2623-22-5

    A trichothecene mycotoxin

  • GC12223 structure
    GC12223Z-Asp-CH2-DCB
    CAS: 153088-73-4
    纯度: >99.00%

    A pan-caspase inhibitor

  • GC12287 structure
    GC12287Z-DEVD-FMK
    CAS: 210344-95-9
    纯度: >95.00% / >98.00% / >98.50%

    Z-DEVD-FMK是一种特异性的不可逆的半胱氨酸-天冬氨酸蛋白酶3（caspase-3）抑制剂，IC 50 为18μM。

  • GC12545 structure
    GC125452-HBA
    CAS: 131359-24-5
    纯度: >98.00%

    An indirect inhibitor of Keap1-Nrf2 interactions

  • GC14188 structure
    GC14188Z-YVAD-FMK
    CAS: 210344-97-1
    纯度: >98.00%

    Z-YVAD-FMK是一种可穿透细胞的不可逆caspase-1和caspase-4 抑制剂。

  • GC15880 structure
    GC15880Penicillic Acid
    CAS: 90-65-3
    纯度: >99.50% / >98.00%

    A mycotoxin that inhibits quorum sensing

  • GC17425 structure
    GC17425Sodium Tauroursodeoxycholate (TUDC)
    CAS: 35807-85-3
    纯度: >98.00%

    Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium 是一种内质网 (ER) 应激抑制剂。 Tauroursodeoxycholate 显着降低凋亡分子的表达，例如 caspase-3 和 caspase-12。 Tauroursodeoxycholate 也抑制 ERK。

  • GC17658 structure
    GC17658Guggulsterone
    CAS: 95975-55-6
    纯度: >99.50%

    Guggulsterone是一种从植物Commiphora wightii的树脂中提取的植物甾醇。Guggulsterone可以抑制多种肿瘤细胞的生长，并通过下调抗凋亡基因产物（IAP1、xIAP、Bfl-1/A1、Bcl-2、cFLIP和survivin）、调节细胞周期蛋白（如Cyclin D1和c-Myc）、激活半胱氨酸蛋白酶、抑制Akt以及激活JNK来诱导细胞凋亡。

  • GC18476 structure
    GC18476Biotin-VAD-FMK
    CAS: 1135688-15-1
    纯度: >98.00%

    A biotin-conjugated pan-caspase inhibitor

  • GC26092 structure
    GC26092Z-LEHD-FMK TFA
    CAS: 524746-03-0

    Z-LEHD-FMK TFA是一种不可逆的caspase-9抑制剂。

  • GC31390 structure
    GC31390EP1013 (F1013)
    CAS: 223568-55-6

    EP1013 (F1013) (F1013) 是一种广谱 caspase 选择性抑制剂，用于 1 型糖尿病的研究。

  • GC31886 structure
    GC31886Chelidonic acid
    CAS: 99-32-1

    A pyran with diverse biological activities

  • GC32695 structure
    GC32695Ac-DEVD-CHO
    CAS: 169332-60-9
    纯度: >98.00%

    Ac-DEVD-CHO是一种Caspase-3抑制剂，IC 50 值为0.016μM。

  • GC32998 structure
    GC32998Ginsenoside Rh4
    CAS: 174721-08-5
    纯度: >98.00%

    Ginsenoside Rh4 is an important active ingredient of traditional Chinese medicine ginseng, which has been shown to inhibit Wnt/β-Catenin, JAK2/STAT3, TGF-β/Smad2/3 and other signaling pathways.

  • GC33309 structure
    GC33309ML132 (NCGC 00185682)
    CAS: 1230628-71-3
    纯度: >98.00%

    ML132 (NCGC 00185682) (NCGC-00183434) 是一种选择性 caspase 1 抑制剂，IC50 为 34.9 nM。

  • GC33825 structure
    GC33825Taurochenodeoxycholic acid (12-Deoxycholyltaurine)
    CAS: 516-35-8
    纯度: >98.00% / >99.00%

    Taurochenodeoxycholic acid (12-Deoxycholyltaurine)是一种牛磺酸结合胆汁酸。

  • GC34181 structure
    GC34181Tauroursodeoxycholate (TUDCA)
    CAS: 14605-22-2
    纯度: >98.00%

    牛磺酸脱氧胆酸盐(TUDCA)是包括肝细胞在内的多种细胞的细胞保护剂,也是癌症细胞凋亡的诱导剂。

  • GC34831 structure
    GC34831Tauroursodeoxycholate dihydrate
    CAS: 117609-50-4
    纯度: >98.00%

    Tauroursodeoxycholatedihydrate(TUDCAdihydrate;UR906dihydrate;Taurolitedihydrate)是一种内质网应激抑制剂。Tauroursodeoxycholate显著降低凋亡分子如caspase-3和caspase-12表达。Tauroursodeoxycholate也抑制ERK。

  • GC35150 structure
    GC351505,7,4'-Trimethoxyflavone
    CAS: 5631-70-9
    纯度: >99.50%

    4',5,7-Trimethoxyflavone (5,7,4'-Trimethoxyflavone, TMF) is a flavonoid isolated from Kaempferia parviflora (KP) that induces apoptosis. 4',5,7-Trimethoxyflavone increases sub-G1 phase, DNA fragmentation, annexin-V/PI staining and Bax/Bcl-xL ratio, activates caspase-3 and degrades poly (ADP-ribose) polymerase (PARP) protein.

  • GC35388 structure
    GC35388Aristolactam I
    CAS: 13395-02-3
    纯度: >99.50%

    Aristololactam I (AL-I) 是马兜铃酸I (AA-I) 的主要代谢产物，参与导致肾损伤的过程。Aristololactam I (AL-I) 直接损伤肾近端小管细胞，AL-I 的细胞毒性效力高于AA-I，并且这些分子的细胞毒性作用是通过 caspase-3 依赖性细胞凋亡介导。