GlpBio

Caspase

Caspase(半胱天冬酶蛋白)

Caspases (cysteine-dependent aspartate specific ptotease) are a family of cysteine proteases that play an essential role in cell apoptosis. Caspases contain a conserved QACXG pentapeptide active site motif and are characterized by specificity for aspartic acid in the P1 position. The synthesis of caspases involves the activation of inactive proenzymes, which contain an N-terminal peptide (prodomain) together with two subunits (one small and one large), following cleavage at specific aspartate cleavage sites. Caspases can be classified into three subfamilies, due to phylogenetic analysis, including an ICE subfamily (caspases-1, -4 and -5), a CED-3/CPP32 subfamily (caspases-3, -6, -7, -8, -9 and -10) and an ICH-1/Nedd2 subfamily (caspase-2).

Caspase 相关产品(113)

  • GC35395 structure
    GC35395Arnicolide D
    CAS: 34532-68-8
    纯度: >98.00%

    A sesquiterpene lactone with anticancer activity

  • GC35908 structure
    GC35908Duocarmycin A
    CAS: 118292-34-5

    Duocarmycin A 是众所周知的抗肿瘤抗生素之一，可有效地使 DNA 中富含 AT 的序列 3' 末端的腺嘌呤 N3 烷基化。Duocarmycin A 作为一种化学治疗剂，通常导致 HLC-2 细胞凋亡，包括染色质浓缩，DNA 直方图模式中的亚 G1 积累，以及procaspase-3 和 9 水平的降低。

  • GC35980 structure
    GC35980Emricasan
    CAS: 254750-02-2
    纯度: >99.50% / >98.00% / >98.50%

    Emricasan是一种口服有效、不可逆的广谱胱天蛋白酶抑制剂，具有良好的药代动力学特征。

  • GC36516 structure
    GC36516Lycopodine
    CAS: 466-61-5

    Lycopodine，一种石松 (Lycopodium clavatumspores) 孢子重要的生物活性成分，通过调节难治性前列腺癌细胞中 5-脂氧合酶 (5-lipoxygenase)，极化线粒体膜电位而不调节 p53 活性来诱导细胞凋亡。 Lycopodine 通过激活 caspase-3 诱导细胞凋亡来抑制 HeLa 细胞的增殖。

  • GC36652 structure
    GC36652MPT0B392
    CAS: 1346169-92-3

    MPT0B392 是一种口服活性的喹啉衍生物，作用于 c-Jun N末端激酶 (JNK) 和 apoptosis 的激活剂。MPT0B392 抑制微管蛋白聚合，通过激活 JNK 诱导细胞有丝分裂停滞，线粒体膜电位丧失和 caspases 裂解，最终导致细胞凋亡。MPT0B392 是一种新型微管解聚剂，可增强西罗莫司对耐药急性白血病细胞和多药耐药细胞系的细胞毒性。

  • GC36855 structure
    GC36855Paris saponin VII
    CAS: 68124-04-9
    纯度: >98.00% / >98.50%

    Chonglou Saponin VII (Dioscinin, Polyphyllin-VII, Paris saponin-VII), a kind of steroidal saponins from Chonglou (Rhizoma Paridis Chonglou), inhibits EMT and reduces the invasion of ovarian cancer cells via the GSK-3β/β-catenin signaling pathway.

  • GC36895 structure
    GC36895Phenoxodiol
    CAS: 81267-65-4
    纯度: >98.00%

    Phenoxodiol是一种异黄酮衍生物，具有抗肿瘤活性。

  • GC37745 structure
    GC37745Taurodeoxycholic acid sodium hydrate
    CAS: 110026-03-4
    纯度: >98.00%

    Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a bile acid, is an amphiphilic surfactant molecule synthesized from cholesterol in the liver. It activates S1PR2 pathway in addition to the TGR5 pathway.

  • GC37780 structure
    GC37780Thevetiaflavone
    CAS: 29376-68-9

    Thevetiaflavone 可以上调 Bcl?2 的表达，下调 Bax 和 caspase-3 的表达。

  • GC37974 structure
    GC37974ZYZ-488
    CAS: 1470302-79-4
    纯度: >99.50%

    ZYZ-488 是一种竞争性凋亡蛋白酶激活因子-1 (Apaf-1) 抑制剂，抑制结合蛋白 procaspase-9 和 procaspase-3 的激活。

  • GC38452 structure
    GC38452Dehydrotrametenolic acid
    CAS: 6879-05-6
    纯度: >99.50%

    Dehydrotrametenolic acid 是从茯苓 (Poria cocos) 的菌核中分离的甾醇。Dehydrotrametenolic acid 通过 caspase-3 途径诱导细胞凋亡。Dehydrotrametenolic acid 具有抗肿瘤活性，抗炎，抗糖尿病作用。

  • GC40118 structure
    GC40118Ac-AAVALLPAVLLALLAP-IETD-CHO (trifluoroacetate salt)
    纯度: >95.00%

    An inhibitor of caspase-8 and granzyme B

  • GC40122 structure
    GC40122Ac-AAVALLPAVLLALLAP-DEVD-CHO (trifluoroacetate salt)
    纯度: >95.00%

    A caspase-3 inhibitor

  • GC40123 structure
    GC40123Ac-AAVALLPAVLLALLAP-VAD-CHO (trifluoroacetate salt)
    纯度: >95.00%

    A non-selective caspase inhibitor

  • GC40125 structure
    GC40125Z-VA-DL-D(OMe)-FMK (trifluoroacetate salt)
    纯度: >95.00%

    A pan-caspase inhibitor

  • GC40149 structure
    GC40149Boc-AEVD-CHO (trifluoroacetate salt)
    纯度: >95.00%

    An inhibitor of caspase-8

  • GC40164 structure
    GC40164Ac-IETD-CHO (trifluoroacetate salt)
    纯度: >95.00%

    Ac-IETD-CHO (trifluoroacetate salt)是一种caspase 8抑制剂，可阻止focal adhesion kinase (Fak)被caspase裂解，IC 50 值为200nM。

  • GC42688 structure
    GC42688Ac-DMQD-CHO (trifluoroacetate salt)
    纯度: >95.00%

    An inhibitor of caspase-3

  • GC42709 structure
    GC42709Ac-LEVD-CHO (trifluoroacetate salt)
    纯度: >95.00%

    A caspase-4 inhibitor

  • GC42715 structure
    GC42715Ac-VDVAD-CHO (trifluoroacetate salt)
    纯度: >95.00%

    A caspase-2, caspase-3, and caspase-7 inhibitor

  • GC42718 structure
    GC42718Ac-VEID-CHO (trifluoroacetate salt)
    纯度: >95.00%

    A caspase-6 inhibitor

  • GC43146 structure
    GC43146Caspase-9 Inhibitor III (trifluoroacetate salt)
    纯度: >95.00%

    A caspase-9 inhibitor

  • GC43154 structure
    GC43154CAY10443
    CAS: 582314-48-5
    纯度: >98.00%

    A cytochrome c-dependent inducer of apoptosis

  • GC44409 structure
    GC44409Nivalenol
    CAS: 23282-20-4
    纯度: >99.00%

    A trichothecene mycotoxin