Ac-LEVD-CHO is a caspase-4 inhibitor.[1] It inhibits IL-1α expression and secretion and caspase-4 activation induced by the T. denticola periodontal pathogen surface protein Td92 in human gingival fibroblasts when used at a concentration of 30 μM. Ac-LEVD-CHO (10 μM) also reduces apoptosis induced by expression of the dominant negative adenoviral RNA-dependent protein kinase (Ad-δ6PKR) in A549 and PC3 cancer cells.[2]
Reference:
[1]. Jun, H.-K., Jung, Y.-J., An, S.-J., et al. Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts. Cell Death Differ. 25(2), 380-391 (2018).
[2]. Pataer, A., Swisher, S.G., Roth, J.A., et al. Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity. Cancer Biol. Ther. 8(3), 245-252 (2009).