GlpBio

Cell Cycle/Checkpoint

Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

研究方向

Cell Cycle/Checkpoint 相关产品(1379)

  • GC10008 structure
    GC10008GSK1070916
    CAS: 942918-07-2
    纯度: >98.50%

    A potent inhibitor of Aurora B and C kinases

  • GC10030 structure
    GC10030EHop-016
    CAS: 1380432-32-5
    纯度: >99.00%

    EHop-016是一种高效的Rac GTP酶Rac1抑制剂，IC 50 值为1.1μM。

  • GC10069 structure
    GC10069NSC 23766 trihydrochloride
    CAS: 1177865-17-6
    纯度: >99.50% / >99.00%

    NSC 23766 trihydrochloride是一种选择性Rac1 GTPase抑制剂，通过特异性阻断Rac1的鸟嘌呤核苷酸交换因子Trio和Tiam1来抑制Rac1的激活，对Rac1的IC₅₀约为50μM。

  • GC10115 structure
    GC10115360A iodide
    CAS: 737763-37-0
    纯度: >98.00%

    360A iodide是一种G-四联体（G-quadruplex）的稳定剂，360A iodide还是有效的端粒酶（telomerase；IC 50 =300nM）的活性抑制剂

  • GC10163 structure
    GC10163MLN0905
    CAS: 1228960-69-7
    纯度: >97.00%

    A Plk1 inhibitor

  • GC10196 structure
    GC10196ETP-46464
    CAS: 1345675-02-6
    纯度: >98.00%

    An ATR inhibitor

  • GC10251 structure
    GC10251FRAX1036
    CAS: 1432908-05-8
    纯度: >99.00%

    A selective PAK1 inhibitor

  • GC10334 structure
    GC10334INH6
    CAS: 1001753-24-7
    纯度: >99.00%

    A Hec1/Nek2 inhibitor

  • GC10479 structure
    GC10479PHA-680632
    CAS: 398493-79-3
    纯度: >99.50%

    An Aurora kinase inhibitor

  • GC10521 structure
    GC10521Podophyllotoxin
    CAS: 518-28-5
    纯度: >99.50%

    A lignan with diverse biological activities

  • GC10638 structure
    GC10638AT9283
    CAS: 896466-04-9
    纯度: >99.50%

    A broad spectrum kinase inhibitor

  • GC10840 structure
    GC10840THZ1
    CAS: 1604810-83-4
    纯度: >98.50%

    A covalent Cdk7 inhibitor

  • GC10842 structure
    GC10842LEE011
    CAS: 1211441-98-3
    纯度: >99.50%

    LEE011是一种具有口服活性的特异性细胞周期蛋白依赖性激酶CDK4/6抑制剂。LEE011以纳摩尔浓度靶向cyclin D1/CDK4和cyclin D3/CDK6。

  • GC11007 structure
    GC11007VO-Ohpic trihydrate
    CAS: 476310-60-8
    纯度: >98.00%

    A specific inhibitor of PTEN

  • GC11085 structure
    GC11085TAK-901
    CAS: 934541-31-8
    纯度: >98.00%

    A non-selective inhibitor of Aurora kinases

  • GC11118 structure
    GC11118KU 55933
    CAS: 587871-26-9
    纯度: >99.50%

    KU 55933是一种高效且特异的ATM激酶抑制剂，能够使人类肿瘤细胞对电离辐射和化疗药物更加敏感。KU 55933在体外的IC₅₀值为13nM，K i 值为2.2nM。

  • GC11202 structure
    GC11202Epothilone A
    CAS: 152044-53-6
    纯度: >98.50%

    An antimicrotubule agent

  • GC11224 structure
    GC11224BI6727(Volasertib)
    CAS: 755038-65-4
    纯度: >99.00%

    BI6727(Volasertib)是一种口服ATP竞争性Polo样激酶（PLK）抑制剂，可强效抑制PLK1、PLK2和PLK3活性，IC 50 值分别为0.87nM、5nM和56nM。

  • GC11310 structure
    GC11310CCT129202
    CAS: 942947-93-5
    纯度: >98.00%

    An Aurora kinase inhibitor

  • GC11324 structure
    GC11324PHA-767491
    CAS: 845714-00-3

    A potent Cdc7 kinase inhibitor

  • GC11511 structure
    GC11511Vincristine sulfate
    CAS: 2068-78-2
    纯度: >99.50%

    An antimitotic inhibitor of tubulin polymerization

  • GC11549 structure
    GC11549VX-680 (MK-0457,Tozasertib)
    CAS: 639089-54-6
    纯度: >99.50%

    VX-680 (MK-0457,Tozasertib)是一种有效的Aurora激酶抑制剂，对Aurora A/B/C的K i 值分别为0.6、18、4.6nM，具有抗癌活性。

  • GC11621 structure
    GC11621GW843682X
    CAS: 660868-91-7
    纯度: >99.50%

    A reversible polo-like kinase inhibitor

  • GC11648 structure
    GC11648BML-277
    CAS: 516480-79-8
    纯度: >98.00%

    A selective DNA damage control kinase inhibitor