GlpBio

ROCK

ROCK(Rho相关蛋白激酶)

ROCK (Rho-associated protein kinase) is a kinase belonging to the AGC family of serine-threonine kinases and takes part in regulating the shape and movement of cells by acting on the cytoskeleton.

ROCK 相关产品(69)

  • GC12491 structure
    GC12491Narciclasine
    CAS: 29477-83-6
    纯度: >99.50%

    Narciclasine是一种具有抗有丝分裂和促凋亡活性的植物生长调节剂。

  • GC12827 structure
    GC12827SLx-2119
    CAS: 911417-87-3
    纯度: >99.50%

    SLx-2119是一种高效的Rho kinase (ROCK) 2抑制剂，IC 50 值为105nM。

  • GC14289 structure
    GC14289Fasudil (HA-1077) HCl
    CAS: 105628-07-7
    纯度: >99.50% / >98.00%

    Fasudil (HA-1077) HCl（法舒地尔；HA-1077；AT877）是一种非特异性RhoA/ROCK抑制剂，对ROCK1的K i 为0.33μM，IC 50 为0.158μM，对ROCK2和PKA、PKC、PKG的IC 50 分别为4.58μM、12.30μM、1.650μM。

  • GC15437 structure
    GC15437RKI-1447
    CAS: 1342278-01-6
    纯度: >98.00%

    A ROCK1 and ROCK2 inhibitor

  • GC16097 structure
    GC16097Chroman 1
    CAS: 1273579-40-0
    纯度: >99.00%

    A ROCK2 inhibitor

  • GC10512 structure
    GC10512Y-27632 dihydrochloride
    CAS: 129830-38-2
    纯度: >98.00%

    Y-27632 dihydrochloride 作为一种选择性 Rho 激酶抑制剂，是一种新型支气管扩张剂。

  • GC10716 structure
    GC10716Netarsudil (AR-13324)
    CAS: 1253952-02-1

    ROCK抑制剂

  • GC11181 structure
    GC11181Thiazovivin
    CAS: 1226056-71-8
    纯度: >99.00% / >98.00%

    Thiazovivin是一种选择性Rho相关激酶（ROCK）抑制剂。

  • GC12314 structure
    GC123143-(4-Pyridyl)indole
    CAS: 7272-84-6
    纯度: >98.00%

    A ROCK1 and ROCK2 inhibitor

  • GC12402 structure
    GC12402LX7101 HCL
    CAS: 1192189-69-7
    纯度: >99.50%

    A LIMK and ROCK inhibitor

  • GC12817 structure
    GC12817K-115 hydrochloride dihydrate
    CAS: 887375-67-9
    纯度: >99.50%

    K-115 hydrochloride dihydrate (K-115) 是 ROCK 的特异性抑制剂，对 ROCK2 和 ROCK1 的 IC50 分别为 19 和 51 nM。

  • GC13759 structure
    GC13759SAR407899
    CAS: 923359-38-0
    纯度: >99.00%

    A ROCK1 and ROCK2 inhibitor

  • GC15170 structure
    GC15170SB 772077B dihydrochloride
    CAS: 607373-46-6
    纯度: >98.50%

    A ROCK1 and ROCK2 inhibitor

  • GC16289 structure
    GC16289SAR407899 hydrochloride
    CAS: 923262-96-8
    纯度: >98.00%

    A ROCK1 and ROCK2 inhibitor

  • GC16475 structure
    GC16475Afuresertib
    CAS: 1047644-62-1
    纯度: >99.50%

    A pan-Akt inhibitor

  • GC17712 structure
    GC17712AT13148
    CAS: 1056901-62-2
    纯度: >99.50%

    A multi-AGC kinase inhibitor

  • GC17936 structure
    GC17936GSK269962A
    CAS: 850664-21-0
    纯度: >99.50%

    A ROCK1 and ROCK2 inhibitor

  • GC18119 structure
    GC18119GSK429286A
    CAS: 864082-47-3
    纯度: >98.50%

    A ROCK inhibitor

  • GC19034 structure
    GC19034AR-13324 mesylate
    CAS: 1422144-42-0

    AR-13324 是一种有效的 ROCK I 和 ROCK II 抑制剂，已被证明可在低浓度下诱导培养的人和猪 TM 细胞发生形态学变化。

  • GC19177 structure
    GC19177GSK180736A
    CAS: 817194-38-0
    纯度: >98.00% / >99.50%

    A ROCK1 and GRK2 inhibitor

  • GC25482 structure
    GC25482GSK269962A HCl
    CAS: 2095432-71-4

    GSK269962A HCl (GSK269962B, GSK269962) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.

  • GC31883 structure
    GC31883ROCK2-IN-2
    CAS: 1995065-79-6

    ROCK2-IN-2是一种选择性ROCK2抑制剂，IC50<1μM。详细信息请参考专利文献US20180093978A1中的化合物A-30。

  • GC31952 structure
    GC31952ROCK-IN-1
    CAS: 934387-35-6

    ROCK-IN-1是一种有效的ROCK抑制剂，能够抑制ROCK2的活性，IC50值为1.2nM。

  • GC32868 structure
    GC32868BDP5290
    CAS: 1817698-21-7
    纯度: >98.50%

    BDP5290对MRCKβ、ROCK1、ROCK2的IC50值分别为17nM、230nM、123nM和100nM，是ROCK和MRCK的有效抑制剂。