GlpBio

ROCK

ROCK(Rho相关蛋白激酶)

ROCK (Rho-associated protein kinase) is a kinase belonging to the AGC family of serine-threonine kinases and takes part in regulating the shape and movement of cells by acting on the cytoskeleton.

ROCK 相关产品(69)

  • GC33120 structure
    GC33120ZINC00881524
    CAS: 557782-81-7
    纯度: >99.00%

    A ROCK inhibitor

  • GC33310 structure
    GC33310Rho-Kinase-IN-1
    CAS: 1035094-83-7
    纯度: >99.50%

    Rho-Kinase-IN-1是一个rho激酶抑制剂，来自专利US20090325960A1，化合物1.008。

  • GC33901 structure
    GC33901Pentanoic acid
    CAS: 109-52-4
    纯度: >99.00%

    Pentanoicacid是一种短链脂肪酸，是细菌代谢产物，与过敏性皮肤病有关系。Pentanoicacid能够激活ROCK信号通路。

  • GC34300 structure
    GC34300AR-13324 analog mesylate
    CAS: 2095432-73-6

    AR-13324类似物甲磺酸盐是AR-13324的类似物。

  • GC35442 structure
    GC35442Azaindole 1
    CAS: 867017-68-3
    纯度: >98.00%

    A ROCK1 and ROCK2 inhibitor

  • GC36207 structure
    GC36207H-1152
    CAS: 451462-58-1

    A ROCK inhibitor

  • GC36208 structure
    GC36208H-1152 dihydrochloride
    CAS: 871543-07-6
    纯度: >99.50%

    H-1152 dihydrochloride (2HCl) is a membrane-permeable and selective inhibitor of Rho-associated protein kinase (ROCK). H-1152 inhibits ROCK2, PKA, PKC, PKG, AuroraA and CaMK2 with IC50 of 0.0120 μM, 3.03 μM, 5.68 μM, 0.360 μM, 0.745 μM and 0.180 μM, respectively.

  • GC37534 structure
    GC37534Ripasudil free base
    CAS: 223645-67-8

    Ripasudil free base (K-115 free base) 是 ROCK 特异性抑制剂，能够抑制 ROCK2 和 ROCK1 的活性，IC50 值分别为 19 和 51 nM。

  • GC37551 structure
    GC37551ROCK inhibitor-2
    CAS: 1127308-52-4
    纯度: >98.00% / >99.50%

    ROCK inhibitor-2是一种选择性Rho激酶（ROCK）抑制剂，抑制ROCK1和ROCK2的IC 50 值分别为17nM和2nM，具有抗肿瘤活性。

  • GC37947 structure
    GC37947Y-33075
    CAS: 199433-58-4
    纯度: >98.00%

    Y-33075是一种有效的ROCK（Rho相关蛋白激酶）抑制剂，IC 50 值为3.6nM。

  • GC38791 structure
    GC38791GSK-25
    CAS: 874119-56-9
    纯度: >99.50%

    GSK-25 是一种有效的、选择性的，具有口服活性的 ROCK1 抑制剂 (IC50=7 nM)。GSK-25 对 31 种激酶以及 RSK1 和 p70S6K 保持良好的选择性 (RSK1: IC50=398 nM, p70S6K: IC50=1 μM)。GSK-25 可抑制 P450 (CYP2C9、CYP2D6、CYP3A4的IC50 分别为2.5、5.2、2.5 μM)。

  • GC38898 structure
    GC38898CCG-222740
    CAS: 1922098-69-8
    纯度: >99.50%

    CCG-222740 is a Rho/MRTF pathway inhibitor. CCG-222740 decreases the activation of stellate cells in vitro and in vivo, by reducing the levels of alpha smooth muscle actin(α-SMA) expression.

  • GC41737 structure
    GC41737(S)-Glycyl-H-1152 (hydrochloride)
    CAS: 913844-45-8
    纯度: >98.00%

    A ROCK inhibitor

  • GC42747 structure
    GC42747Afuresertib (hydrochloride)
    CAS: 1047645-82-8
    纯度: >98.00%

    A pan-Akt inhibitor

  • GC43184 structure
    GC43184CAY10622
    CAS: 1038549-25-5
    纯度: >98.00%

    A ROCK1 and ROCK2 inhibitor

  • GC43286 structure
    GC43286CMPD101
    CAS: 865608-11-3
    纯度: >98.50%

    CMPD101是一种高效、高选择性且具有膜通透性的小分子G蛋白偶联受体激酶2（GRK2）和GRK3抑制剂，其对GRK2和GRK3的IC 50 值分别为18nM和5.4nM。

  • GC43803 structure
    GC43803HA-1077 (hydrochloride)
    CAS: 203911-27-7
    纯度: >98.00%

    A ROCK inhibitor

  • GC44094 structure
    GC44094LX7101 (hydrochloride)
    CAS: 2319882-48-7
    纯度: >98.00%

    A LIMK and ROCK inhibitor

  • GC44847 structure
    GC44847RKI-1313
    CAS: 1342276-76-9
    纯度: >98.00%

    A ROCK1 and ROCK2 inhibitor

  • GC45414 structure
    GC45414CRT0066854
    CAS: 1438881-19-6
    纯度: >99.00%

    A PKCι and PKCζ inhibitor

  • GC49334 structure
    GC49334Chroman 1 (hydrochloride hydrate)
    纯度: >98.00%

    A ROCK2 inhibitor

  • GC50043 structure
    GC50043SR 3677 dihydrochloride
    CAS: 1781628-88-3

    A ROCK1 and ROCK2 inhibitor

  • GC50092 structure
    GC50092RKI 1447 dihydrochloride
    CAS: 1782109-09-4
    纯度: >98.00%

    A ROCK1 and ROCK2 inhibitor

  • GC50116 structure
    GC50116OXA 06 dihydrochloride
    CAS: 1825455-91-1

    Potent ROCK inhibitor