GlpBio

Cyclin-Dependent Kinases

Cyclin-Dependent Kinases(细胞周期蛋白依赖性激酶)

Cyclin-dependent kinases is a group of serine/threonine kinases. It is activated by binding to cyclin and participates in the regulation of cell cycle.

Cyclin-Dependent Kinases 相关产品(69)

  • GC10840 structure
    GC10840THZ1
    CAS: 1604810-83-4
    纯度: >98.50%

    A covalent Cdk7 inhibitor

  • GC10842 structure
    GC10842LEE011
    CAS: 1211441-98-3
    纯度: >99.50%

    LEE011是一种具有口服活性的特异性细胞周期蛋白依赖性激酶CDK4/6抑制剂。LEE011以纳摩尔浓度靶向cyclin D1/CDK4和cyclin D3/CDK6。

  • GC12438 structure
    GC12438AZD-5438
    CAS: 602306-29-6
    纯度: >99.50%

    A potent inhibitor of CDKs

  • GC17648 structure
    GC17648Dinaciclib(SCH727965)
    CAS: 779353-01-4
    纯度: >98.00%

    A CDK inhibitor

  • GC11396 structure
    GC11396SNS-032 (BMS-387032)
    CAS: 345627-80-7
    纯度: >99.00%

    A Cdk2, Cdk7, and Cdk9 inhibitor

  • GC11401 structure
    GC11401Roscovitine (Seliciclib,CYC202)
    CAS: 186692-46-6
    纯度: >98.50% / >98.00%

    Roscovitine (Seliciclib,CYC202)是一种有效的Cdk2/cyclin E抑制剂，IC 50 值为0.1μM。Roscovitine还抑制Cdk7/cyclin H、Cdk5/p35以及（cdc）/cyclin B，IC 50 值分别为0.49、0.16和0.65μM。

  • GC11410 structure
    GC11410Aminopurvalanol A
    CAS: 220792-57-4

    A selective CDK inhibitor

  • GC11564 structure
    GC11564Cdk4/6 Inhibitor IV
    CAS: 359886-84-3

    A cell-permeable inhibitor of Cdk4/6

  • GC11634 structure
    GC11634NSC 693868
    CAS: 40254-90-8

    A selective inhibitor of Cdk1 and Cdk5

  • GC11785 structure
    GC11785CDK4 inhibitor
    CAS: 1256963-02-6

    An antiproliferative cyclin D1/Cdk4 inhibitor

  • GC11823 structure
    GC11823LY2835219 free base
    CAS: 1231929-97-7
    纯度: >99.50% / >97.00% / >99.00%

    LY2835219 free base是 CDK4 和 CDK6 的强效选择性抑制剂，在非细胞实验中的 IC 50 分别为 2nM 和 10nM。

  • GC11835 structure
    GC11835Deferasirox
    CAS: 201530-41-8
    纯度: >99.50%

    Deferasirox是一种具口服活性的铁螯合剂，用于治疗铁过载疾病。

  • GC11944 structure
    GC11944PF 4800567 hydrochloride
    CAS: 1391052-28-0

    A selective CK1ε inhibitor

  • GC11971 structure
    GC11971LY2857785
    CAS: 1619903-54-6
    纯度: >98.50%

    A Cdk9 inhibitor

  • GC12001 structure
    GC12001BS-181
    CAS: 1092443-52-1

    A selective Cdk7 inhibitor

  • GC12064 structure
    GC12064SB1317
    CAS: 937270-47-8
    纯度: >99.50%

    A multi-kinase inhibitor

  • GC12348 structure
    GC12348Ro 3306
    CAS: 872573-93-8
    纯度: >98.00%

    Ro 3306是一种ATP竞争性抑制剂，主要靶向CDK1/cyclin B1（K i 值为35nmol/L）和CDK1/cyclin A复合物（K i 值为110nmol/L）。

  • GC12425 structure
    GC12425CDK inhibitor II
    CAS: 1269815-17-9
    纯度: >98.50%

    CDK inhibitor II 是一种有效且特异性的 CDK9 抑制剂，IC50 <8 nM，取自参考文献 1，实施例 4。

  • GC12826 structure
    GC12826AZD-5597
    CAS: 924641-59-8

    Potent CDK inhibitor

  • GC12865 structure
    GC12865BMS265246
    CAS: 582315-72-8
    纯度: >99.00%

    A cell-permeable inhibitor of Cdk1 and Cdk2

  • GC12871 structure
    GC12871CDK9 inhibitor
    CAS: 1415559-43-1
    纯度: >98.50%

    CDK9 inhibitor 是一种新型的选择性 CDK9 抑制剂，用于治疗 HIV 感染，对 CDK9/CycT1 的 IC50 为 39 nM，从参考化合物 87 中提取。

  • GC12886 structure
    GC12886NSC 625987
    CAS: 141992-47-4

    A Cdk4/cyclin D1 complex inhibitor

  • GC13100 structure
    GC13100[Ala92]-p16 (84-103)
    CAS: 189064-08-2

    inhibitor of cyclin-dependent kinase-4 (cdk4)/cyclin D1

  • GC13511 structure
    GC13511THZ2
    CAS: 1604810-84-5
    纯度: >99.50%

    A Cdk7 inhibitor