Mps1
Mps1(单极纺锤体1激酶)
MPS1 (monopolar spindle 1 kinase) is a crucial part of the spindle assembly checkpoint. It facilitates the formation of C-MAD2 (closed MAD2) conformer and the MCC (mitotic checkpoint complex) assembly, and involved in the tumor growth.
Mps1 相关产品(13)
- GC32846BOS-172722CAS: 1578245-44-9纯度: >99.00%
BOS172722 is a monopolar spindle 1 (MPS1) checkpoint inhibitor with IC50 of 11 nM, Ki of 0.11 nM.
- GC34073Empesertib (BAY 1161909)CAS: 1443763-60-7纯度: >98.00%
Empesertib (BAY1161909, Mps1-IN-5), a derivative of triazolopyridine, is an orally bioavailable, selective inhibitor of the serine/threonine monopolar spindle 1 (Mps1) kinase with IC50 of <1 nM. Empesertib has potential antineoplastic activity.
- GC65339Mps1-IN-3 hydrochloride纯度: >98.00%
Mps1-IN-3 hydrochloride 是一种有效且具有选择性的 Mps1 抑制剂，IC50 为 50 nM。Mps1-IN-3 hydrochloride 可抑制胶质母细胞瘤细胞的增殖，并在原位异种移植瘤模型中能有效地使胶质母细胞瘤对长春新碱敏感。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC15283 | AZ3146 | 1124329-14-1 | >99.50% | |
A selective inhibitor of the spindle checkpoint kinase Mps1 | ||||
| GC10083 | MPI-0479605 | 1246529-32-7 | >99.00% | |
A potent inhibitor of MPS1 | ||||
| GC11292 | Mps1-IN-1 | 1125593-20-5 | >99.50% | |
A selective Mps1 kinase inhibitor | ||||
| GC13727 | TC Mps1 12 | 1206170-62-8 | >99.00% | |
TC Mps1 12 是一种有效的选择性单极纺锤体 1 (Mps1) 抑制剂，IC50 为 6.4 nM。 | ||||
| GC19058 | BAY1217389 | 1554458-53-5 | >99.50% / >98.00% | |
An orally bioavailable inhibitor of Mps1 | ||||
| GC32846 | BOS-172722 | 1578245-44-9 | >99.00% | |
BOS172722 is a monopolar spindle 1 (MPS1) checkpoint inhibitor with IC50 of 11 nM, Ki of 0.11 nM. | ||||
| GC33213 | CCT251455 | 1400284-80-1 | >98.00% | |
CCT251455是有效和选择性的有丝分裂激酶单极纺锤体1(MPS1)抑制剂，IC50值为3nM。 | ||||
| GC34073 | Empesertib (BAY 1161909) | 1443763-60-7 | >98.00% | |
Empesertib (BAY1161909, Mps1-IN-5), a derivative of triazolopyridine, is an orally bioavailable, selective inhibitor of the serine/threonine monopolar spindle 1 (Mps1) kinase with IC50 of <1 nM. Empesertib has potential antineoplastic activity. | ||||
| GC36651 | Mps1-IN-3 | 1609584-72-6 | >99.00% | |
Mps1-IN-3 是一种有效的，选择性的 MPS1 抑制剂，IC50 值为 50 nM。 | ||||
| GC36752 | NMS-P715 | 1202055-32-0 | >99.50% | |
An Mps1/TTK inhibitor | ||||
| GC50110 | Mps1-IN-1 dihydrochloride | 1883548-93-3 | - | |
A selective Mps1 kinase inhibitor | ||||
| GC65339 | Mps1-IN-3 hydrochloride | - | >98.00% | |
Mps1-IN-3 hydrochloride 是一种有效且具有选择性的 Mps1 抑制剂，IC50 为 50 nM。Mps1-IN-3 hydrochloride 可抑制胶质母细胞瘤细胞的增殖，并在原位异种移植瘤模型中能有效地使胶质母细胞瘤对长春新碱敏感。 | ||||
| GC15745 | Mps1-IN-2 | 1228817-38-6 | >98.00% | |
An inhibitor of Mps1 | ||||