GlpBio

Cell Cycle/Checkpoint

Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

研究方向

Cell Cycle/Checkpoint 相关产品(1379)

  • GC16273 structure
    GC16273Dolastatin 10
    CAS: 110417-88-4
    纯度: >98.50%

    Dolastatin 10 (DLS 10) 是一种有效的抗有丝分裂肽，可抑制微管蛋白聚合。

  • GC17067 structure
    GC17067LDC000067
    CAS: 1073485-20-7
    纯度: >98.50%

    A Cdk9 inhibitor

  • GC17388 structure
    GC17388K-Ras(G12C) inhibitor 6
    CAS: 2060530-16-5

    K-Ras(G12C) inhibitor 6 是一种不可逆的 K-Ras(G12C) 变构抑制剂。

  • GC17400 structure
    GC17400R547
    CAS: 741713-40-6
    纯度: >99.50%

    A selective Cdk inhibitor

  • GC10722 structure
    GC10722SR-3677
    CAS: 1072959-67-1
    纯度: >99.50%

    A ROCK1 and ROCK2 inhibitor

  • GC10442 structure
    GC10442MK-8745
    CAS: 885325-71-3
    纯度: >99.00%

    An Aurora A kinase inhibitor

  • GC12515 structure
    GC12515NMS-1286937
    CAS: 1034616-18-6
    纯度: >99.00% / >98.00%

    NMS-1286937是一种口服有效的小分子化合物，能够高效且选择性地抑制Polo样激酶1（PLK1）的活性，半数抑制浓度（IC 50 ）为2nM。

  • GC12642 structure
    GC12642THZ1 Hydrochloride
    CAS: 1604810-83-4
    纯度: >98.00%

    A covalent Cdk7 inhibitor

  • GC13869 structure
    GC13869Fasudil
    CAS: 103745-39-7
    纯度: >98.00%

    Fasudil（法舒地尔；HA-1077；AT877）是一种非特异性RhoA/ROCK抑制剂，对ROCK1的K i 为0.33μM，IC 50 为0.158μM，对ROCK2和PKA、PKC、PKG的IC 50 分别为4.58μM、12.30μM、1.650μM。

  • GC14735 structure
    GC14735Poloxime
    CAS: 17302-61-3

    Poloxime 是 poloxin 的水解产物，是一种非 ATP 竞争性 Plk1 抑制剂，具有中等的 Plk1 抑制活性。

  • GC15571 structure
    GC15571SU 9516
    CAS: 377090-84-1
    纯度: >99.50%

    A pro-apoptotic Cdk2/cyclin A inhibitor