GlpBio

Wee1

Wee1(Wee1蛋白激酶)

Wee1 is a tyrosine kinase nuclear protein that catalyzes tyrosine phosphorylation of CDC2/Cyclin B kinase. It negatively regulates the entry to mitosis by protecting nucleus from cytoplasmically activated CDC2 kinase.

Wee1 相关产品(8)

  • GC16030 structure
    GC16030MK-1775
    CAS: 955365-80-7
    纯度: >99.50%

    MK-1775 是一种有效的选择性 Wee1 激酶小分子抑制剂，IC50 值为 5.2 nM。

  • GC32853 structure
    GC32853PD0166285
    CAS: 185039-89-8
    纯度: >99.00%

    PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations (IC50=24 nM for Wee1 and 72 nM for Myt1). PD0166285 is also a novel G2 checkpoint abrogator. PD0166285 induces apoptosis.

  • GC50045 structure
    GC50045PD 166285 dihydrochloride
    CAS: 212391-63-4

    A tyrosine kinase inhibitor

  • GC62449 structure
    GC62449WEE1-IN-3
    CAS: 2272976-28-8
    纯度: >98.00%

    WEE1-IN-3 是一种有效的 Wee1 激酶抑制剂，其 IC50 <10 nM。WEE1-IN-3 具有抗癌活性。

  • GC62697 structure
    GC62697ZN-c3
    CAS: 2376146-48-2
    纯度: >99.50%

    ZN-c3 is an oral active, highly effective and selective Wee1 inhibitor with IC50 of 3.9 nM, which can be used in cancer research.

  • GC65994 structure
    GC65994WEE1-IN-5
    CAS: 2243882-74-6

    Debio 0123 is an inhibitor of Wee1 kinase which is a key regulator of the G2/M and S phase checkpoints.

  • GC71010 structure
    GC71010RSS0680
    CAS: 2769753-48-0
    纯度: >98.00%

    RSS0680（实施例22）是一种靶向激酶蛋白质降解的双功能化合物。

  • GC72924 structure
    GC72924PD173952
    CAS: 305820-75-1
    纯度: >99.00%

    PD173952是一种酪氨酸激酶抑制剂，对Lyn、Abl和Csk的ic50分别为0.3、1.7和6.6 nM。