Arp2/3 Complex
Arp2/3 Complex(Arp2/3 复合体)
The intact ARP2/3 complex is first purified from Acanthamoeba castellanii based on its affinity for the actin-binding protein profilin, and is shown to consist of a stable assembly of seven polypeptides. Two of the subunits are actin-related proteins of the ARP2 and ARP3 subfamilies, giving the complex its name.
The ARP2/3 complex possesses little biochemical activity on its own. However, when engaged by nucleation-promoting factor (NPF) proteins, it is activated to initiate the formation of a new (daughter) filament that emerges from an existing (mother) filament in a y-branch configuration with a regular 70° branch angle. This coupling of nucleation and branching by the ARP2/3 complex is referred to as autocatalytic branching or dendritic nucleation, and is central to its functions in vivo.
Polymerization of actin filaments directed by the Arp2/3 complex supports many types of cellular movements.
Arp2/3 Complex 相关产品(8)
- GC32890Cytochalasin B (Phomin)CAS: 14930-96-2纯度: {{1-3}>99.00% / {4-13}>98.00%} / {14}>99.50%}
Cytochalasin B(细胞松弛素B)是一种可渗透细胞的真菌毒素,从Phoma属的子囊菌真菌中分离得到。
- GC43461Dihydrocytochalasin BCAS: 39156-67-7纯度: >95.00%
An inhibitor of actin assembly and cytokinesis
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC13440 | Cytochalasin D | 22144-77-0 | >95.00% / >98.00% | |
An inhibitor of actin polymerization | ||||
| GC14060 | CK 666 | 442633-00-3 | >99.50% | |
CK 666是一种可穿透细胞的肌动蛋白相关蛋白Arp2/3复合物抑制剂（IC 50 =12μM）。 | ||||
| GC15076 | CK 869 | 388592-44-7 | >99.50% | |
An inhibitor of the Arp2/3 complex | ||||
| GC15671 | Latrunculin A | 76343-93-6 | >95.00% | |
一种可逆抑制肌动蛋白聚合的药物 | ||||
| GC15894 | CK-636 | 442632-72-6 | >98.00% | |
An inhibitor of Arp2/3 complex action | ||||
| GC32890 | Cytochalasin B (Phomin) | 14930-96-2 | {{1-3}>99.00% / {4-13}>98.00%} / {14}>99.50%} | |
Cytochalasin B(细胞松弛素B)是一种可渗透细胞的真菌毒素,从Phoma属的子囊菌真菌中分离得到。 | ||||
| GC43461 | Dihydrocytochalasin B | 39156-67-7 | >95.00% | |
An inhibitor of actin assembly and cytokinesis | ||||
| GC61831 | Benproperine phosphate | 19428-14-9 | >98.00% | |
An antitussive agent and ARPC2 inhibitor | ||||