GlpBio

CK 869

目录号: GC15076纯度: >99.50%同义词: CK-0157869
An inhibitor of the Arp2/3 complex
CK 869
Cas No.: 388592-44-7
规格价格库存数量操作
1mg¥186.00现货
1
5mg¥490.00现货
1
10mg¥665.00现货
1
25mg¥1,064.00现货
1
50mg¥1,435.00现货
1
100mg¥1,937.00现货
1
10mM (in 1mL DMSO)¥539.00现货
1
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文献被引

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    610, 366–372 (2022)
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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

产品描述 Description

CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor, with an IC50 of 7 μM.

CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor, with an IC50 of 7 μM[1]. CK-869 significantly inhibits MT polymerization even at a concentration of 25 μM[2].

References:
[1]. Hetrick B, et al. Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol. 2013 May 23;20(5):701-12.
[2]. Yamagishi Y, et al. Use of CK-548 and CK-869 as Arp2/3 complex inhibitors directly suppresses microtubule assembly both in vitro and in vivo. Biochem Biophys Res Commun. 2018 Feb 12;496(3):834-839.

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号
388592-44-7
同义词
CK-0157869
化学名
2-(3-bromophenyl)-3-(2,4-dimethoxyphenyl)thiazolidin-4-one
SMILES
COC1=CC(OC)=C(N2C(CSC2C3=CC(Br)=CC=C3)=O)C=C1
分子式
C17H16BrNO3S
分子量
394.28 g/mol
溶解性
DMF: 1.5 mg/ml,DMSO: 2.5 mg/ml,DMSO:PBS (pH 7.2) (1:20): 0.05 mg/ml
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol