Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that selectively inhibits HIV-1 reverse transcriptase over DNA polymerase α and δ in vitro (IC50s = 0.26, 440, and >550 μM, respectively).1 It inhibits growth of clinical isolates of HIV-1 (ED50s = <0.005-0.69 μM). Delavirdine blocks replication of 25 primary HIV-1 isolates, including strains resistant to 3'-azido-2',3'-deoxythymidine (AZT) or 2',3'-dideoxyinosine, with a mean ED50 value of 0.066 μM. Delavirdine also inhibits growth of L. infantum promastigotes (IC50 = 26.1 μM).2 Formulations containing delavirdine have been used in the treatment of HIV.
1.Dueweke, T.J., Poppe, S.M., Romero, D.L., et al.U-90152, a potent inhibitor of human immunodeficiency virus type 1 replicationAntimicrob. Agents Chemother.37(5)1127-1131(1993) 2.Costa, S., Machado, M., Cavadas, C., et al.Antileishmanial activity of antiretroviral drugs combined with miltefosineParasitol Res.115(10)3881-3887(2016)