ATM/ATR

ATM (ataxia telangiectasia mutated) and ATR (ATM- and Rad3-related) are two PIKKs (phosphatidylinositol 3-kinase-like kinases) that regulate the DNA damage response (DDR) pathways.

ATM/ATR 相关产品(29)

GC10196 ETP-46464
CAS: 1345675-02-6
纯度: >98.00%
An ATR inhibitor
GC11118 KU 55933
CAS: 587871-26-9
纯度: >99.50%
KU 55933是一种高效且特异的ATM激酶抑制剂，能够使人类肿瘤细胞对电离辐射和化疗药物更加敏感。KU 55933在体外的IC₅₀值为13nM，K i 值为2.2nM。
GC12054 KU-60019
CAS: 925701-46-8
纯度: >98.50% / >98.00%
A potent ATM kinase inhibitor
GC14526 CGK733
CAS: 905973-89-9
纯度: >99.50%
An anticancer compound
GC14949 AZ20
CAS: 1233339-22-4
纯度: >99.50%
A potent, selective ATR inhibitor
GC15337 Berzosertib (VE-822)
CAS: 1232416-25-9
Berzosertib (VE-822)是一种静脉给药的、高度强效且选择性的ATR抑制剂(IC 50 =19nM)。
GC16489 CP-466722
CAS: 1080622-86-1
纯度: >99.50%
An ATM kinase inhibitor
GC10293 VE-821
CAS: 1232410-49-9
纯度: >98.50%
An inhibitor of ATR
GC11593 AZD0156
CAS: 1821428-35-6
纯度: >98.00%
An ATM kinase inhibitor
GC13491 Mirin
CAS: 1198097-97-0
纯度: >99.50%
Mirin是一种Mre11-Rad50-Nbs1（MRN）复合物抑制剂（IC 50 =12μM），能够抑制Mre11相关的外切酶活性，Mirin可抑制MRN依赖的ATM的激活。通常用于与DNA修复机制相关的癌症的研究。
GC16941 AZD6738
CAS: 1352226-88-0
纯度: >98.50%
AZD6738是一种具有口服活性和高效选择性的共济失调毛细血管扩张和Rad3相关蛋白（ATR）激酶抑制剂，IC 50 值为1nM。
GC19047 AZ32
CAS: 2288709-96-4
纯度: >99.50%
An ATM kinase inhibitor
GC19468 AZD1390
CAS: 2089288-03-7
纯度: >99.50%
AZD1390是一种新型选择性共济失调毛细血管扩张突变激酶抑制剂，能够高效穿透血脑屏障。
GC25372 Elimusertib (BAY-1895344) hydrochloride
Elimusertib (BAY-1895344) hydrochloride is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.
GC33404 KU 59403
CAS: 845932-30-1
纯度: >98.50%
KU59403是ATM的一个有效抑制剂，其IC50值为3nM。
GC33420 BAY-1895344
CAS: 1876467-74-1
纯度: >99.50%
An ATR inhibitor
GC34374 BAY-1895344 hydrochloride
An ATR inhibitor
GC34999 (S)-Ceralasertib
CAS: 1352226-87-9
(S)-Ceralasertib 从专利 WO2011154737A1 中获取，化合物 II，IC50 为 2.578 nM。(S)-Ceralasertib 是一种有效的选择性亚砜亚胺吗啉代嘧啶 ATR 抑制剂，具有优异的临床前物化和药代动力学 (PK) 特征。(S)-Ceralasertib 水溶性改善，并且消除 CYP3A4 时间依赖性抑制。
GC50424 AZ 5704
CAS: 1941214-06-7
Potent and selective ATM kinase inhibitor; orally bioavailable
GC62108 Elimusertib hydrochloride
纯度: >99.50%
Elimusertib (BAY 1895344) hydrochloride 是一种有效、可口服、选择性的 ATR 抑制剂，IC50 值为 7 nM，具有抗肿瘤活性。Elimusertib hydrochloride 可用于实体瘤和淋巴瘤的研究。
GC64278 RP-3500
CAS: 2417489-10-0
RP-3500 (Camonsertib, ATR inhibitor) is a highly potent and selective inhibitor of ATR kinase with an IC50 of 1 nM.
GC64539 SKLB-197
CAS: 2713577-16-1
纯度: >99.00%
SKLB-197 exerts selectively inhibition against ataxia telangiectasia mutated and Rad3-related (ATR) kinase with IC50 of 0.013 μM, also displays potent antitumor activity against ATM-deficent tumors both in vitro and in vivo.
GC64938 AZD-7648
CAS: 2230820-11-6
纯度: >99.50%
An inhibitor of DNA-PK
GC65327 ATM Inhibitor-5
CAS: 2495096-26-7
M4076 inhibits Ataxia telangiectasia-mutated (ATM) kinase activity with a sub-nanomolar potency and shows remarkable selectivity against other protein kinases, suppresses DSB repair, clonogenic cancer cell growth, and potentiates antitumor activity of ionizing radiation in cancer cell lines.

分类产品列表
货号	产品名称	CAS号	纯度
GC10196	ETP-46464	1345675-02-6	>98.00%
GC10196	An ATR inhibitor
GC11118	KU 55933	587871-26-9	>99.50%
GC11118	KU 55933是一种高效且特异的ATM激酶抑制剂，能够使人类肿瘤细胞对电离辐射和化疗药物更加敏感。KU 55933在体外的IC₅₀值为13nM，K i 值为2.2nM。
GC12054	KU-60019	925701-46-8	>98.50% / >98.00%
GC12054	A potent ATM kinase inhibitor
GC14526	CGK733	905973-89-9	>99.50%
GC14526	An anticancer compound
GC14949	AZ20	1233339-22-4	>99.50%
GC14949	A potent, selective ATR inhibitor
GC15337	Berzosertib (VE-822)	1232416-25-9	-
GC15337	Berzosertib (VE-822)是一种静脉给药的、高度强效且选择性的ATR抑制剂(IC 50 =19nM)。
GC16489	CP-466722	1080622-86-1	>99.50%
GC16489	An ATM kinase inhibitor
GC10293	VE-821	1232410-49-9	>98.50%
GC10293	An inhibitor of ATR
GC11593	AZD0156	1821428-35-6	>98.00%
GC11593	An ATM kinase inhibitor
GC13491	Mirin	1198097-97-0	>99.50%
GC13491	Mirin是一种Mre11-Rad50-Nbs1（MRN）复合物抑制剂（IC 50 =12μM），能够抑制Mre11相关的外切酶活性，Mirin可抑制MRN依赖的ATM的激活。通常用于与DNA修复机制相关的癌症的研究。
GC16941	AZD6738	1352226-88-0	>98.50%
GC16941	AZD6738是一种具有口服活性和高效选择性的共济失调毛细血管扩张和Rad3相关蛋白（ATR）激酶抑制剂，IC 50 值为1nM。
GC19047	AZ32	2288709-96-4	>99.50%
GC19047	An ATM kinase inhibitor
GC19468	AZD1390	2089288-03-7	>99.50%
GC19468	AZD1390是一种新型选择性共济失调毛细血管扩张突变激酶抑制剂，能够高效穿透血脑屏障。
GC25372	Elimusertib (BAY-1895344) hydrochloride	-	-
GC25372	Elimusertib (BAY-1895344) hydrochloride is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.
GC33404	KU 59403	845932-30-1	>98.50%
GC33404	KU59403是ATM的一个有效抑制剂，其IC50值为3nM。
GC33420	BAY-1895344	1876467-74-1	>99.50%
GC33420	An ATR inhibitor
GC34374	BAY-1895344 hydrochloride	-	-
GC34374	An ATR inhibitor
GC34999	(S)-Ceralasertib	1352226-87-9	-
GC34999	(S)-Ceralasertib 从专利 WO2011154737A1 中获取，化合物 II，IC50 为 2.578 nM。(S)-Ceralasertib 是一种有效的选择性亚砜亚胺吗啉代嘧啶 ATR 抑制剂，具有优异的临床前物化和药代动力学 (PK) 特征。(S)-Ceralasertib 水溶性改善，并且消除 CYP3A4 时间依赖性抑制。
GC50424	AZ 5704	1941214-06-7	-
GC50424	Potent and selective ATM kinase inhibitor; orally bioavailable
GC62108	Elimusertib hydrochloride	-	>99.50%
GC62108	Elimusertib (BAY 1895344) hydrochloride 是一种有效、可口服、选择性的 ATR 抑制剂，IC50 值为 7 nM，具有抗肿瘤活性。Elimusertib hydrochloride 可用于实体瘤和淋巴瘤的研究。
GC64278	RP-3500	2417489-10-0	-
GC64278	RP-3500 (Camonsertib, ATR inhibitor) is a highly potent and selective inhibitor of ATR kinase with an IC50 of 1 nM.
GC64539	SKLB-197	2713577-16-1	>99.00%
GC64539	SKLB-197 exerts selectively inhibition against ataxia telangiectasia mutated and Rad3-related (ATR) kinase with IC50 of 0.013 μM, also displays potent antitumor activity against ATM-deficent tumors both in vitro and in vivo.
GC64938	AZD-7648	2230820-11-6	>99.50%
GC64938	An inhibitor of DNA-PK
GC65327	ATM Inhibitor-5	2495096-26-7	-
GC65327	M4076 inhibits Ataxia telangiectasia-mutated (ATM) kinase activity with a sub-nanomolar potency and shows remarkable selectivity against other protein kinases, suppresses DSB repair, clonogenic cancer cell growth, and potentiates antitumor activity of ionizing radiation in cancer cell lines.