Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

Products for Cell Cycle/Checkpoint

Cat.No. 产品名称 Information
GC46796 Ac-WEHD-AFC (trifluoroacetate salt)

N-Acetyl-Trp-Glu-His-Asp-7-amino-4-Trifluoromethylcoumarin, Caspase1 Substrate (Fluorogenic), Caspase5 Substrate (Fluorogenic)
A neuropeptide with diverse biological activities
GC18021 Ac-YVAD-CHO

乙酰基-酪氨酰-缬氨酰-丙氨酰-天冬氨醛,L-709049
An inhibitor of caspase-1
GC42721 Ac-YVAD-CMK

Caspase-1 Inhibitor II
Ac-YVAD-CMK 是一种选择性不可逆的 caspase-1 抑制剂 (Ki=0.8nM)，可阻止促炎细胞因子 IL-1β 的激活。
GC10244 Ac2-12 Ac2-12 是一种膜联蛋白/脂皮质素 1 (LC1) 模拟肽，可抑制中性粒细胞外渗。
GC15598 Ac2-26 An annexin A1-mimetic peptide
GC46786 Acetyl Hexapeptide-3 (acetate)

Ac-EEMQRR-NH2, Acetyl-Glu-Glu-Met-Gln-Arg-Arg-NH2, Acetyl Hexapeptide-8
A synthetic hexapeptide
GC42701 Acetyl Tetrapeptide-3

乙酰基四肽-3
A biomimetic peptide
GC49699 Acetyl Tetrapeptide-9 (acetate)

AcTP1, N-acetyl-Gln-Asp-Val-His
A synthetic signal peptide
GC46790 Acibenzolar-S-methyl

S-甲基苯并[1,2,3]噻二唑-7-硫代羧酸酯,BTH
A fungicide inducer of systemic acquired resistance
GC68614 AcLys-PABC-VC-Aur0101 AcLys-PABC-VC-Aur0101 是抗体偶联活性分子 (抗 CXCR4 ADC) 的一部分。由 Aur0101 (一种 auristatin 微管抑制剂) 和可降解 linker AcLys-PABC-VC 连接而成。
GC49804 Acridine

吖啶
An azaarene
GC41242 Acridine Orange

吖啶橙,NSC 194350
Acridine Orange是一种可穿透细胞的核酸选择性荧光染料， Acridine Orange可与DNA或RNA结合时产生荧光，与双链DNA结合时产生绿色荧光（激发光为488nm；发射光为530nm绿色荧光）。
GC46810 Aflatoxin B1-13C17

黄曲霉毒素B1-(全碳-13)
An internal standard for the quantification of aflatoxin B₁
GC46811 Aflatoxin B2-13C17

黄曲霉毒素B2-(全碳-13)
An internal standard for the quantification of aflatoxin B₂
GC46814 Aflatoxin M1-13C17

AFM1-13C17
A neuropeptide with diverse biological activities
GC16475 Afuresertib

GSK2110183
A pan-Akt inhibitor
GC42747 Afuresertib (hydrochloride)

GSK2110183 hydrochloride
A pan-Akt inhibitor
GC35262 Afzelin

阿福豆苷,Kaempferol-3-O-rhamnoside
A polyphenolic glycoside flavone with diverse biological activities
GC62433 AKI603 AKI-603 is an inhibitor of Aurora kinase A (AurA), which is developed to overcome resistance mediated by BCR-ABL-T315I mutation.
GC46825 Alachlor

甲草胺
An herbicide
GC19897 Albendazole Sulfone

阿苯达唑砜
An active metabolite of albendazole
GC49773 Albendazole sulfone-d3

阿苯哒唑砜-D3
An internal standard for the quantification of albendazole sulfone
GC48848 Albendazole-d7

阿苯达唑-D7,SKF-62979-d7
An internal standard for the quantification of albendazole
GC92051 Alkyne-Cyclo(RGDyK) (trifluoroacetate salt)

Alkyne-c(RGDyK)
Alkyne-Cyclo(RGDyK) (trifluoroacetate salt)是αVβ3整合素环肽配体环（RGDyK）的可点击形式。
GC40094 all-trans Retinoic Acid-d5

atRA-d5, RA-d5, Vitamin A Acid-d5
An internal standard for the quantification of all-trans retinoic acid
GC49393 all-trans-13,14-Dihydroretinol A metabolite of all-trans retinoic acid
GC18539 all-trans-4-hydroxy Retinoic Acid

维甲酸杂质

A metabolite of all-trans retinoic acid
GC40476 Allethrin

丙烯菊酯
A pyrethroid insecticide
GC45379 Alloxan (hydrate)

阿脲一水合物
A toxin that selectively eliminates pancreatic β-cells
GC18386 Aloisine RP106

7-丁基-6-(4-甲氧基苯基)-5H-吡咯并[2,3-B]吡嗪
An inhibitor of Cdk1, Cdk5, and GSK3
GC15841 Alsterpaullone

阿特波龙,9-Nitropaullone,NSC 705701
A dual CDK and GSK3 inhibitor
GC18437 Alternariol monomethyl ether

交链孢霉甲基醚
A mycotoxin
GC64698 AM-5308 AM-5308 是一种有效的驱动蛋白 KIF18A 抑制剂 (WO2021211549A1, C13)。
GC14974 AMG 925 A dual inhibitor of FLT3 and Cdk4
GC39156 AMG PERK 44 AMG PERK 44 是一种口服有效的，高选择性的 PERK 抑制剂，IC50 为 6 nM。AMG PERK 44 对 PERK 的选择性分别是 GCN2 (IC50=7300 nM) 和 B-Raf (IC50 >1000 nM) 的 1000 倍和 160 倍。
GC13198 AMG-900 A selective pan-Aurora kinase inhibitor
GC45809 AMG-Tie2-1

4-甲基-3-[[3-[2-(甲基氨基)-4-嘧啶基]-2-吡啶基]氧基]-N-[3-(三氟甲基)苯基]苯甲酰胺
A Tie2 and VEGFR2 inhibitor
GC46841 Amiloride (hydrochloride) (hydrate)

MK-870
具有多种生物活性的神经肽
GC65578 Aminobenzenesulfonic auristatin E TFA Aminobenzenesulfonic auristatin E TFA 是抗体偶联药物的一部分，由细胞毒性微管蛋白修饰剂 Auristatin E 和 ADC linker Aminobenzenesulfonic 连接而成，具有抗肿瘤活性。
GC42788 Aminopeptidase N Inhibitor Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM).
GC11410 Aminopurvalanol A

NG 97
A selective CDK inhibitor
GC18274 Amiprofos-methyl

甲基胺草磷,BAY-NTN 6867
An herbicide
GC33370 Amphethinile (Amphetinile)

Amphetinile; CRC 82-07
Amphetinile (Amphetinile) 是一种抗微管蛋白剂。 Amphetinile (Amphetinile) 与微管蛋白结合的亲和常数 (Ka) 为 1.3 μM。
GC16391 Amuvatinib (MP-470, HPK 56)

N-(1,3-苯并二氧戊环-5-基甲基)-4-苯并呋喃并[3,2-D]嘧啶-4-基-1-哌嗪硫代甲酰胺,MP470,MP 470,HPK56
A multi-targeted RTK inhibitor
GC33362 Amuvatinib hydrochloride (MP470 hydrochloride)

MP470 hydrochloride; HPK 56 hydrochloride
A multi-targeted RTK inhibitor
GC64273 AMXI-5001 AMXI-5001 是一种有效的、具有口服活性的 parp1/2 和微管聚合抑制剂。MXI-5001 对多种人类癌细胞表现出选择性抗肿瘤细胞毒性，其 IC50s 比现有的临床 PARP1/2 抑制剂低得多。AMXI-5001 诱导已建立的肿瘤完全消退，包括非常大的肿瘤。
GC67900 AMXI-5001 hydrochloride AMXI-5001 hydrochloride 是一种有效的、具有口服活性的 parp1/2 和微管聚合抑制剂。MXI-5001 hydrochloride 对多种人类癌细胞表现出选择性抗肿瘤细胞毒性，其 IC50s 比现有的临床 PARP1/2 抑制剂低得多。AMXI-5001 hydrochloride 诱导已建立的肿瘤完全消退，包括非常大的肿瘤。
GC17284 Anacardic acid

漆树酸; Hydroginkgolic acid; Ginkgolic Acid C15

A histone acetyltransferase inhibitor
GC49419 Aniline-d5

苯胺-2,3,4,5,6-d5
An internal standard for the quantification of aniline
GC11947 Ansamitocin P-3

安丝菌素P 3; Antibiotic C 15003P3; Maytansinol isobutyrate
A microtubule depolymerizing agent