GlpBio

Cell Cycle/Checkpoint

Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

研究方向

Cell Cycle/Checkpoint 相关产品(1379)

  • GC13282 structure
    GC13282ARRY-520 R enantiomer
    CAS: 885060-08-2
    纯度: >98.50%

    ARRY-520 R 对映异构体 ((R)-ARRY-520) 是 Filanesib 的 R-对映异构体。 Filanesib 是一种合成的纺锤体驱动蛋白 (KSP) 抑制剂，IC50 为 6 nM。

  • GC13328 structure
    GC13328XL413 hydrochloride
    CAS: 2062200-97-7
    纯度: >99.50%

    A potent inhibitor of Cdc7

  • GC13394 structure
    GC13394Ispinesib (SB-715992)
    CAS: 336113-53-2
    纯度: >98.00%

    An Eg5 inhibitor

  • GC13543 structure
    GC13543Poloxin
    CAS: 321688-88-4
    纯度: >98.50%

    An inhibitor of the Plk1 polo-box domain

  • GC13837 structure
    GC13837SNS-314 Mesylate
    CAS: 1146618-41-8
    纯度: >99.50%

    A pan-Aurora kinase inhibitor

  • GC13903 structure
    GC13903Ro3280
    CAS: 1062243-51-9
    纯度: >99.00%

    A selective Plk1 inhibitor

  • GC14234 structure
    GC14234PF-477736
    CAS: 952021-60-2
    纯度: >99.00%

    A selective inhibitor of checkpoint kinase 1

  • GC14289 structure
    GC14289Fasudil (HA-1077) HCl
    CAS: 105628-07-7
    纯度: >99.50% / >98.00%

    Fasudil (HA-1077) HCl（法舒地尔；HA-1077；AT877）是一种非特异性RhoA/ROCK抑制剂，对ROCK1的K i 为0.33μM，IC 50 为0.158μM，对ROCK2和PKA、PKC、PKG的IC 50 分别为4.58μM、12.30μM、1.650μM。

  • GC14354 structure
    GC14354Eribulin
    CAS: 253128-41-5
    纯度: >99.50%

    Eribulin (E7389) 是一种微管靶向剂，用于研究转移性乳腺癌。艾日布林通过结合微管蛋白和微管来抑制癌细胞的增殖。

  • GC14409 structure
    GC14409ZM 447439
    CAS: 331771-20-1
    纯度: >98.00%

    Selective inhibitor of Aurora B kinase

  • GC14517 structure
    GC14517KPT-185
    CAS: 1333151-73-7

    An inhibitor of XPO1/CRM1

  • GC14526 structure
    GC14526CGK733
    CAS: 905973-89-9
    纯度: >99.50%

    An anticancer compound

  • GC14566 structure
    GC14566CCT137690
    CAS: 1095382-05-0
    纯度: >99.00%

    An inhibitor of Aurora kinases and FLT3

  • GC14615 structure
    GC14615KPT-9274
    CAS: 1643913-93-2

    Orally acitve allosteric inhibitor of PAK4

  • GC14651 structure
    GC14651Reversine
    CAS: 656820-32-5
    纯度: >98.00%

    Reversine是一种靶向Aurora A激酶、Aurora B激酶和MPS1（Monopolar Spindle 1）激酶的非特异性、具有口服活性的小分子抑制剂。Reversine常用于细胞分化和多种癌症的研究。

  • GC14709 structure
    GC14709AZD1152
    CAS: 722543-31-9
    纯度: >99.50%

    AZD1152是一种高度选择性的Aurora B激酶（AURKB）抑制剂，IC 50 值为0.37nM。AZD1152是一种前体药物，在体内转化为活性形式AZD1152-hydroxyquinazoline pyrazol anilide（AZD1152-hQPA），主要用于研究与治疗急性髓系白血病等恶性肿瘤。

  • GC14800 structure
    GC14800ML 141
    CAS: 71203-35-5
    纯度: >98.50% / >98.00%

    An allosteric Cdc42 inhibitor

  • GC14949 structure
    GC14949AZ20
    CAS: 1233339-22-4
    纯度: >99.50%

    A potent, selective ATR inhibitor

  • GC14955 structure
    GC14955Barasertib (AZD1152-HQPA)
    CAS: 722544-51-6
    纯度: >99.00%

    A selective Aurora kinase B inhibitor

  • GC15106 structure
    GC15106CYC116
    CAS: 693228-63-6
    纯度: >98.00%

    A potent Aurora kinase inhibitor

  • GC15162 structure
    GC15162Pyridostatin
    CAS: 1085412-37-8
    纯度: >98.00%

    Pyridostatin是一种高选择性的 G-quadruplex DNA 稳定剂 (Kd=490 nM),而不考虑序列可变性。

  • GC15217 structure
    GC15217Danusertib (PHA-739358)
    CAS: 827318-97-8
    纯度: >98.50%

    A pan-Aurora kinase and Abl inhibitor

  • GC15283 structure
    GC15283AZ3146
    CAS: 1124329-14-1
    纯度: >99.50%

    A selective inhibitor of the spindle checkpoint kinase Mps1

  • GC15337 structure
    GC15337Berzosertib (VE-822)
    CAS: 1232416-25-9

    Berzosertib (VE-822)是一种静脉给药的、高度强效且选择性的ATR抑制剂(IC 50 =19nM)。