Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

Products for Cell Cycle/Checkpoint

Cat.No. 产品名称 Information
GC40202 7α-hydroxy Cholesterol-d7

7ALPHA-羟基胆固醇-25,26,26,26-27,27,27-D7,7α-hydroxycholesterol-d7
An internal standard for the quantification of 7α-hydroxy cholesterol
GC46733 7,12-Dimethylbenz[a]anthracene

9,10-二甲基-1,2-苯并蒽；DMBA
7,12-Dimethylbenz[a]anthracene是一种免疫抑制剂，也是一种强效的器官特异性致癌物。
GC35188 7-Epi-10-oxo-docetaxel

7-表-10-氧多西他塞,Docetaxel Impurity 2
7-Epi-10-oxo-docetaxel (Docetaxel Impurity 2) 是多西他赛（docetaxel）的杂质。
GC35189 7-Epi-docetaxel

7-表多西他赛,4-epi-Docetaxel; 7-Epidocetaxel; 7-Epitaxotere
7-Epi-10-oxo-docetaxel (Docetaxel Impurity C; 7-Epitaxotere)是多西他赛（docetaxel）的杂质。
GN10625 7-Epitaxol

7-表紫杉醇; 7-epi-Paclitaxel
An active metabolite of paclitaxel
GC42610 7-hydroxy Pestalotin

LL-P880β
A fungal metabolite
GC42616 7-oxo Staurosporine

BMY 41950, RK-1409
An antibiotic with diverse biological activities
GC35197 7-xylosyltaxol

7-木糖基紫杉醇,7-Xylosylpaclitaxel; Taxol-7-xyloside
A taxane with microtubule disruptor and anticancer activities
GC49443 7α-hydroxy Cholesterol

胆甾-5-烯-3,7二醇
An oxysterol and bile acid precursor
GC52126 8-chloro Caffeine

茶苯海明相关物质E
A derivative of caffeine
GC40844 9-(2,2-Dicyanovinyl)julolidine

9-(2,2-二氰乙烯基)久洛啶,9-(2,2-Dicyanovinyl)julolidine
A fluorogenic dye
GC48986 9-hydroxy Stearic Acid

9-羟基十八酸
A hydroxy fatty acid
GC13100 [Ala92]-p16 (84-103) inhibitor of cyclin-dependent kinase-4 (cdk4)/cyclin D1
GC68588 AA-T3A-C12 AA-T3A-C12 是一种茴香酰胺配体-栓系类脂质 (AA-lipidoid)。AA-T3A-C12 介导大量 RNA 递送和活化的成纤维细胞的转染。
GC42665 AAF-CMK (trifluoroacetate salt)

NAlaAlaPheCMK, Tripeptidyl Peptidase Inhibitor II
An inhibitor of TPPII
GC35216 AAPK-25 AAPK-25 是一种有效选择性的 Aurora/PLK 激酶双重抑制剂，具有抗肿瘤活性。AAPK-25 可引起有丝分裂延迟并阻滞前中期细胞，通过生物标志物组蛋白 H3Ser10 磷酸化反应，随后细胞凋亡激增。AAPK-25 靶向 Aurora-A, -B, -C 的 Kd 值为 23 nM-289 nM，靶向 PLK-1, -2, -3 的 Kd 值为 55-456 nM。
GC25025 Abraxane

Nab-Paclitaxel

Abraxane (Nab-Paclitaxel), a novel solvent-free taxane with the binding ratio of Paclitaxel to human serum albumin of 1:9, is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimer and inhibits microtubule depolymerization to stabilize the microtubule system.
GC15875 ABT-751 (E7010)

N-[2-[(4-羟基苯基)氨基]-3-吡啶基]-4-甲氧基苯磺酰胺,E7010
An inhibitor of microtubule polymerization
GC42683 Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp A sensitive substrate for neutrophil elastase
GC52499 Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp (trifluoroacetate salt) A sensitive substrate for neutrophil elastase
GC42684 Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp (trifluoroacetate salt)
A sensitive substrate for proteinase 3
GC40122 Ac-AAVALLPAVLLALLAP-DEVD-CHO (trifluoroacetate salt)

Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Glu-Val-Asp-CHO, Ac-AAVALLPAVLLALLAP-DEVD-aldehyde, Ac-AAVALLPAVLLALLAPDEVD-CHO, Caspase-3 Inhibitor I, DEVD-CHO-CPP 32
A caspase-3 inhibitor
GC40118 Ac-AAVALLPAVLLALLAP-IETD-CHO (trifluoroacetate salt)

Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-CHO, Caspase-8 Inhibitor I
An inhibitor of caspase-8 and granzyme B
GC40123 Ac-AAVALLPAVLLALLAP-VAD-CHO (trifluoroacetate salt)

Caspase Inhibitor II, Ac-AAVALLPAVLLALLAP-VAD-aldehyde, Ac-AAVALLPAVLLALLAPVAD-CHO
A non-selective caspase inhibitor
GA20494 Ac-Asp-Glu-Val-Asp-pNA

Ac-Asp-Glu-Val-Asp-pNA
A colorimetric caspase substrate
GC48470 Ac-DEVD-CHO (trifluoroacetate salt)

N-Ac-Asp-Glu-Val-Asp-CHO
A dual caspase-3/caspase-7 inhibitor
GC48430 Ac-DEVD-CMK (trifluoroacetate salt)

AcAspGluValAspCMK, Caspase3 Inhibitor III
An inhibitor of caspase-3
GC42687 Ac-DMQD-AMC (trifluoroacetate salt)

Ac-Asp-Met-Gln-Asp-AMC, Ac-Asp-Met-Gln-Asp-7-amino-4-methylcoumarin
A fluorogenic substrate for caspase-3
GC42688 Ac-DMQD-CHO (trifluoroacetate salt)

Ac-Asp-Met-Gln-Asp-CHO, Caspase-3 Inhibitor
An inhibitor of caspase-3
GC42689 Ac-DNLD-AMC

Ac-Asp-Asn-Leu-Asp-MCA, N-Acetyl-Asp-Asn-Leu-Asp-7-amido-Methylcoumarin, Caspase-3 Substrate
A fluorogenic caspase-3 substrate
GC40154 Ac-ESMD-CHO (trifluoroacetate salt)

Ac-Glu-Ser-Met-Asp-CHO
An inhibitor of caspase-3 maturation
GC49704 Ac-FLTD-CMK (trifluoroacetate salt)

Ac-Phe-Leu-Thr-Asp-CMK
An inhibitor of caspase-1, -4, -5, and -11
GC42706 Ac-IEPD-AMC (trifluoroacetate salt)

Acetyl-Ile-Glu-Pro-Asp-7-amino-4-Methylcoumarin, Ac-Ile-Glu-Pro-Asp-AMC
A fluorogenic substrate for granzyme B
GC40152 Ac-IEPD-pNA (trifluoroacetate salt)

Ac-Ile-Glu-Pro-Asp-p-nitroanilide, Caspase-8 Chromogenic Substrate, Granzyme B Substrate VIII
A colorimetric granzyme B and caspase-8 substrate
GC40164 Ac-IETD-CHO (trifluoroacetate salt)

Caspase-8 Inhibitor
A caspase-8 inhibitor
GC42708 Ac-LEHD-AFC (trifluoroacetate salt)

N-Acetyl-Leu-Glu-His-Asp-7-amino-4-Trifluoromethylcoumarin, Caspase-9 substrate (Fluorogenic)
A caspase-4, -5, and -9 fluorogenic substrate
GC18226 Ac-LEHD-AMC (trifluoroacetate salt)

Ac-Leu-Glu-His-Asp-AMC, Caspase-9 Substrate
A caspase-9 fluorogenic substrate
GC46791 Ac-LEHD-pNA (trifluoroacetate salt)

Ac-Leu-Glu-His-Asp-pNA, Caspase-9 Chromogenic Substrate I
A neuropeptide with diverse biological activities
GC40556 Ac-LETD-AFC

NAcetylLeuGluThrAsp7amino4Trifluoromethylcoumarin, Caspase8 Substrate (Fluorogenic)
A caspase-8 fluorogenic substrate
GC15171 Ac-LEVD-AFC

Ac-Leu-Glu-Val-Asp-AFC, Ac-Leu-Glu-Val-Asp-7-amino-4-trifluormethylcoumarin
A fluorogenic substrate for caspase-4
GC42709 Ac-LEVD-CHO (trifluoroacetate salt)

Ac-Leu-Glu-Val-Asp-CHO, Caspase-4 Inhibitor I
A caspase-4 inhibitor
GC13400 Ac-VDVAD-AFC

N-Acetyl-Val-Asp-Val-Ala-Asp-7-amino-4-Trifluoromethylcoumarin Caspase-2 Substrate (Fluorogenic)
A fluorogenic substrate for caspase-2
GC52372 Ac-VDVAD-AFC (trifluoroacetate salt)

N-Acetyl-Val-Asp-Val-Ala-Asp-AFC, N-Acetyl-Val-Asp-Val-Ala-Asp-7-amino-4-Trifluoromethylcoumarin, Caspase-2 Substrate (Fluorogenic)
A fluorogenic substrate for caspase-2
GC42715 Ac-VDVAD-CHO (trifluoroacetate salt)

Ac-Val-Asp-Val-Ala-Asp-CHO
A caspase-2, caspase-3, and caspase-7 inhibitor
GC42716 Ac-VDVAD-pNA (trifluoroacetate salt)

Ac-Val-Asp-Val-Ala-Asp-pNA, Caspase-2 Chromogenic Substrate, acetyl-Val-Asp-Val-Ala-Asp-p-nitroanilide, acetyl-VDVAD-p-nitroanilide
A colorimetric caspase-2 substrate
GC48974 Ac-VEID-AMC (ammonium acetate salt)

NAcetylValGluIleAsp7amido4Methylcoumarin, Caspase6 Substrate (Fluorogenic)
A caspase-6 fluorogenic substrate
GC42718 Ac-VEID-CHO (trifluoroacetate salt)

Ac-Val-Glu-Ile-Asp-CHO
A caspase-6 inhibitor
GC40162 Ac-VEID-pNA (trifluoroacetate salt)

Ac-Val-Glu-Ile-Asp-pNA, Ac-Val-Glu-Ile-Asp-p-nitroanilide, Caspase-6 Chromogenic Substrate
A colorimetric caspase-6 substrate
GC40124 Ac-WEAD-AMC (trifluoroacetate salt)

Ac-Trp-Glu-Ala-Asp-AMC
A caspase-1 and caspase-4 fluorogenic substrate
GC42719 Ac-WEAD-pNA (trifluoroacetate salt)

Ac-Trp-Glu-Ala-Asp-pNA, Ac-Trp-Glu-Ala-Asp-p-nitroanilide, Caspase-1 and Caspase-4 Chromogenic Substrate
A colorimetric caspase-1 and caspase-4 substrate