Caspase(半胱天冬酶蛋白)

Caspases (cysteine-dependent aspartate specific ptotease) are a family of cysteine proteases that play an essential role in cell apoptosis. Caspases contain a conserved QACXG pentapeptide active site motif and are characterized by specificity for aspartic acid in the P1 position. The synthesis of caspases involves the activation of inactive proenzymes, which contain an N-terminal peptide (prodomain) together with two subunits (one small and one large), following cleavage at specific aspartate cleavage sites. Caspases can be classified into three subfamilies, due to phylogenetic analysis, including an ICE subfamily (caspases-1, -4 and -5), a CED-3/CPP32 subfamily (caspases-3, -6, -7, -8, -9 and -10) and an ICH-1/Nedd2 subfamily (caspase-2).

Products for Caspase

Cat.No. 产品名称 Information
GN10686 Ginsenoside Rh2
人参皂苷 Rh2; 20(S)-Ginsenoside Rh2; 20(S)-Rh2; Ginsenoside-Rh2
A natural steroid glycoside with diverse effects
GN10564 Ecdysterone
β-蜕皮甾酮; 20-Hydroxyecdysone
Ecdysterone是一种天然存在的蜕皮激素，能够控制节肢动物的蜕皮（换羽）和变态。
GC11993 PAC-1
Procaspase activating compound 1
PAC-1是一种具有口服活性的小分子procaspase-3激活剂，可诱导癌细胞凋亡，EC₅₀为2.08μM。
GC15066 Z-FA-FMK
半胱氨酸蛋白酶抑制剂,Z-FA-FMK, Z-Phe-Ala-fluoromethyl ketone, Z-Phe-Ala-FMK, Zfa-FMK, Z-Phe-Ala-CH2F, Cathepsin B, Caspase Inhibitor
An inhibitor of cysteine proteases, including cathepsin B
GC11713 Q-VD(OMe)-OPh
Q-VD(OMe)-OPh
Pan-caspase inhibitor
GC10160 Apoptosis Inhibitor
2,2′-亚甲基双(1,3-环己二酮)
A cell-permeable inhibitor of caspase-3 activation
GC12190 Z-WEHD-FMK
N-[苄氧羰基]-L-色氨酰-L-ALPHA-谷氨酰-N-[(1S)-3-氟-1-(2-甲氧基-2-氧代乙基)-2-氧代丙基]-L-组胺酰胺甲基酯,Z-WEHD-FMK, Caspase-5 Inhibitor (fluoromethylketone)
Z-WEHD-FMK 是一种有效的、细胞渗透性和不可逆的 caspase-1/5 抑制剂。 Z-WEHD-FMK 还表现出对组织蛋白酶 B 活性的强大抑制作用 (IC50=6 μM)。 Z-WEHD-FMK 可用于研究细胞凋亡的证据。
GC13413 Z-VEID-FMK
Caspase-6 inhibitor (fluoromethylketone),Benzyloxycarbonyl-Val-Glu(OMe)-Ile-Asp(OMe)-fluoromethylketone
Caspase-6抑制剂
GC11218 Z-VDVAD-FMK
Z-VDVAD-fluoromethylketone, Caspase-2 Inhibitor (fluoromethylketone),Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-FMK
Z-VDVAD-FMK是一种不可逆的、具有细胞渗透性的caspase-2特异性抑制剂。
GC16744 Z-DQMD-FMK
Z-DQMD-FMK,Benzyloxycarbonyl-Asp(OMe)-Gln-Met-Asp(OMe)-fluoromethylketone
Caspase-3 inhibitor,cell-permeable
GC12287 Z-DEVD-FMK
CASPASE-3抑制剂,Caspase-3 Inhibitor II,Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-FMK
Z-DEVD-FMK是一种特异性的不可逆的半胱氨酸-天冬氨酸蛋白酶3（caspase-3）抑制剂，IC₅₀为18μM。
GC16774 Boc-D-FMK
(3S)-3-[[叔丁氧羰基]氨基]-5-氟-4-氧代-戊酸甲酯,Caspase Inhibitor III, Boc-Asp(OMe)-FMK, Boc-D(OMe)-FMK, Caspase3-Inhibitor BOC-D-FMK, Boc-Asp(OMe)-fluoromethylketone

Boc-D-FMK is a cell-permeable broad-spectrum caspase inhibitor that fully inhibits the pro-apoptotic effect of tumor necrosis factor-α (TNFα) with the half maximal inhibition concentration IC50 value of 39 μM .
GC16316 Q-VD-OPh hydrate
(3S)-5-(2,6-二氟苯氧基)-3-[[(2S)-3-甲基-1-氧代-2-[(2-喹啉甲酰基)氨基]丁基]氨基]-4-氧代-戊酸,QVD-OPH; Quinoline-Val-Asp-Difluorophenoxymethylketone
Q-VD-OPh hydrate是一种广谱、可渗透细胞、高效且无毒的caspase抑制剂，对重组caspase1,3,8和9的IC₅₀值在25-400nM范围内。