Asperosaponin VI is a triterpenoid saponin that has been found in D. asper and has diverse biological activities.1,2,3 It increases bone morphogenetic protein 2 (BMP2) levels in, and induces differentiation of, MC3T3-E1 mouse preosteoblasts in a concentration-dependent manner.1 It also inhibits osteoclast formation induced by RANKL in vitro and reduces joint inflammation and bone loss in a mouse model of collagen-induced arthritis when administered at a dose of 20 mg/kg.2 Asperosaponin VI (150 and 450 mg/kg) reduces increases in acetic acid-induced vascular permeability and increases the latency to paw withdrawal in the hot plate test in mice.3
1.Niu, Y., Li, Y., Huang, H., et al.Asperosaponin VI, a saponin component from Dipsacus asper wall, induces osteoblast differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathwayPhytother. Res.25(11)1700-1706(2011) 2.Liu, K., Liu, Y., Xu, Y., et al.Asperosaponin VI protects against bone destructions in collagen induced arthritis by inhibiting osteoclastogenesisPhytomedicine63153006(2019) 3.Gong, L.-L., Yang, S., Liu, H., et al.Anti-nociceptive and anti-inflammatory potentials of Akebia saponin DEur. J. Pharmacol.84585-90(2019)