GlpBio

KEA1-97

目录号: GC63031纯度: >99.50%
KEA1-97 是一种选择性Thioredoxin-caspase 3相互作用干扰剂 (IC50=10 μM)。KEA1-97 在不影响 thioredoxin 活性的情况下, 破坏 thioredoxin 与 caspase 3 的相互作用, 激活 caspases, 诱导细胞 apoptosis。
KEA1-97
Cas No.: 2138882-71-8
规格价格库存数量操作
5mg¥450.00现货
1
10mg¥765.00现货
1
25mg¥1,575.00现货
1
50mg¥2,520.00现货
1
100mg¥4,140.00现货
1
10mM (in 1mL DMSO)¥495.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    641, 529–536 (2025)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

产品描述 Description

KEA1-97 is a selective Thioredoxin-caspase 3 interaction disruptor (IC50=10 μM). KEA1-97 disrupts the interaction of thioredoxin with caspase 3, activates caspases, and induces apoptosis without affecting thioredoxin activity[1].

KEA1-97 (100 μM; 231MFP cells) impaires thioredoxin pulldown of caspase 3[1].KEA1-97 (10 μM; 48 hours; 231MFP cells) impaires 231MFP serum-free cell proliferation[1].KEA1-97 (10 μM; 0~12 hours; 231MFP cells) activates caspase 3/7 and induces apoptotic cell death[1].KEA1-97 (231MFP cells) resistants to survival and proliferation impairments[1].

KEA1-97 (5 mg/kg; i.p.; 50 days) attenuates tumor xenograft growth[1].

[1]. Anderson KE, et al. Chemoproteomics-Enabled Covalent Ligand Screening Reveals a Thioredoxin-Caspase 3 Interaction Disruptor That Impairs Breast Cancer Pathogenicity. ACS Chem Biol. 2017;12(10):2522-2528.

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号
2138882-71-8
分子式
C15H9Cl2FN4
分子量
335.16 g/mol
溶解性
DMSO : 100 mg/mL (298.36 mM; Need ultrasonic)
保存条件
4°C, protect from light
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol