Ac-DEVD-CMK (trifluoroacetate salt)

Ac-DEVD-CMK is a cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, -7, -8, and -10.^1,2,3 It is commonly used at concentrations up to 100 μM to examine the role of caspase-3-dependent apoptosis in biological systems.^4,1

1.Mocanu, M.M., Baxter, G.F., and Yellon, D.M.Caspase inhibition and limitation of myocardial infarct size: Protection against lethal reperfusion injuryBritish Journal of Pharmacology130(2)197-200(2000) 2.Schrantz, N., Blanchard, D.A., Mitenne, F., et al.Manganese induces apoptosis of human B cells: Caspase-dependent cell death blocked by Bcl-2Cell Death and Differentiation6(5)445-453(1999) 3.Thornberry, N.A., and Lazebnik, Y.Caspases: Enemies withinScience2811312-1316(1998) 4.Zhang, Y., Wang, H., Li, J., et al.Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activationJournal of Neuroscience24(47)10616-10627(2004)