GlpBio

Caspase

Caspase(半胱天冬酶蛋白)

Caspases (cysteine-dependent aspartate specific ptotease) are a family of cysteine proteases that play an essential role in cell apoptosis. Caspases contain a conserved QACXG pentapeptide active site motif and are characterized by specificity for aspartic acid in the P1 position. The synthesis of caspases involves the activation of inactive proenzymes, which contain an N-terminal peptide (prodomain) together with two subunits (one small and one large), following cleavage at specific aspartate cleavage sites. Caspases can be classified into three subfamilies, due to phylogenetic analysis, including an ICE subfamily (caspases-1, -4 and -5), a CED-3/CPP32 subfamily (caspases-3, -6, -7, -8, -9 and -10) and an ICH-1/Nedd2 subfamily (caspase-2).

Caspase 相关产品(113)

  • GC12407 structure
    GC12407Z-IETD-FMK
    CAS: 210344-98-2
    纯度: >98.00%

    Z-IETD-FMK（Z-IE(OMe)TD(OMe)-FMK）是一种选择性和细胞可渗透的 caspase-8抑制剂。

  • GC16744 structure
    GC16744Z-DQMD-FMK

    Caspase-3 inhibitor,cell-permeable

  • GC11713 structure
    GC11713Q-VD(OMe)-OPh

    Pan-caspase inhibitor

  • GC16990 structure
    GC16990Z-LEHD-FMK
    CAS: 210345-04-3
    纯度: >98.00%

    Z-LEHD-FMK是一种不可逆的caspase-9抑制剂。

  • GC11908 structure
    GC11908Cisplatin
    CAS: 15663-27-1
    纯度: >98.00% / >99.00% / >99.50%

    顺铂是最好的、最早的基于金属的化疗药物之一，用于治疗广泛的实体癌症，如睾丸癌、卵巢癌、膀胱癌、肺癌、宫颈癌、头颈部肿瘤和胃癌等。

  • GC11993 structure
    GC11993PAC-1
    CAS: 315183-21-2
    纯度: >98.00%

    PAC-1是一种具有口服活性的小分子procaspase-3激活剂，可诱导癌细胞凋亡，EC 50 为2.08μM。

  • GC14209 structure
    GC14209Apoptosis Activator 2
    CAS: 79183-19-0
    纯度: >98.00%

    An activator of caspases

  • GC14886 structure
    GC14886PETCM
    CAS: 10129-56-3

    PETCM 是 caspase-3 的激活剂，并以细胞色素 c (细胞 c) 依赖性方式发挥作用。 PETCM 促进 Apaf-1 寡聚化并诱导 HeLa 细胞中的细胞凋亡。

  • GC15066 structure
    GC15066Z-FA-FMK
    CAS: 197855-65-5
    纯度: >98.00%

    An inhibitor of cysteine proteases, including cathepsin B

  • GC10160 structure
    GC10160Apoptosis Inhibitor
    CAS: 54135-60-3
    纯度: >97.50%

    A cell-permeable inhibitor of caspase-3 activation

  • GC18137 structure
    GC18137Ivachtin
    CAS: 745046-84-8
    纯度: >98.00%

    A reversible caspase-3 inhibitor

  • GC13171 structure
    GC13171AZ 10417808
    CAS: 331645-84-2

    Caspase-3 inhibitor,selective non-peptide

  • GC16774 structure
    GC16774Boc-D-FMK
    CAS: 634911-80-1
    纯度: >95.00%

    Boc-D-FMK is a cell-permeable broad-spectrum caspase inhibitor that fully inhibits the pro-apoptotic effect of tumor necrosis factor-α (TNFα) with the half maximal inhibition concentration IC50 value of 39 μM .

  • GC10968 structure
    GC10968Ac-LEHD-AFC
    CAS: 210345-03-2

    A caspase-4, -5, and -9 fluorogenic substrate

  • GC12190 structure
    GC12190Z-WEHD-FMK
    CAS: 210345-00-9
    纯度: >98.50%

    Z-WEHD-FMK 是一种有效的、细胞渗透性和不可逆的 caspase-1/5 抑制剂。 Z-WEHD-FMK 还表现出对组织蛋白酶 B 活性的强大抑制作用 (IC50=6 μM)。 Z-WEHD-FMK 可用于研究细胞凋亡的证据。

  • GC10258 structure
    GC10258Ac-IEPD-AFC
    CAS: 1135417-31-0

    Ac-IEPD-AFC 是颗粒酶 B 的底物。

  • GC12139 structure
    GC12139Gambogic Acid
    CAS: 2752-65-0

    Gambogic Acid 是一种细胞渗透性 caspase 激活剂和细胞凋亡诱导剂，常用于乳腺癌、肺癌和肝癌等的研究。