GlpBio

Thrombin

Thrombin(凝血酶)

Thrombin is a Na+ -activated allosteric serine protease that catalyzes the formation of thrombus as well as a series of flux-regulating reactions through the coagulation cascade. In response to vascular injury, thrombin is produced through the activation of its inactive precursor, prothrobin, catalyzed by Factor Xa (a trypsin-like proteinase). As a serine protease characterized by the presence of a catalytic triad, thrombin possess a triad of S195-H57-D189 in its active center, which is required for the nucleophilic attack of the target peptide bond. Located “south-west” of the active center is a Na+ -binding site, through which the binding of a sodium ion allosterically modulates the activity of the serine proteinase.

Thrombin 相关产品(44)

  • GC10277 structure
    GC10277PPACK Dihydrochloride
    纯度: >98.00%

    PPACK是一种有效的选择性和不可逆凝血酶抑制剂，能够抑制人α凝血酶，Ki值为0.24 nM。

  • GC10448 structure
    GC10448Bivalirudin Trifluoroacetate
    CAS: 128270-60-0

    A thrombin inhibitor

  • GC11101 structure
    GC111015-R-Rivaroxaban
    CAS: 865479-71-6
    纯度: >99.50%

    5-R-Rivaroxaban 是 Rivaroxaban 的 (R)-对映异构体。

  • GC11644 structure
    GC11644Edoxaban
    CAS: 480449-70-5
    纯度: >98.00%

    Edoxaban (DU-176b) 是一种具有口服活性、高效、选择性和直接的因子 Xa (FXa) 抑制剂，对游离人 FXa 和凝血酶原酶的 Ki 值分别为 0.561 和 2.98 nM。

  • GC12839 structure
    GC12839Edoxaban tosylate monohydrate
    CAS: 1229194-11-9
    纯度: >99.50%

    A potent inhibitor of Factor Xa

  • GC12875 structure
    GC12875Dabigatran ethyl ester
    CAS: 429658-95-7
    纯度: >98.00%

    达比加群乙酯是一种新兴的口服抗凝剂，是凝血酶活性的直接抑制剂。

  • GC15180 structure
    GC15180BIBR-1048
    CAS: 211915-06-9
    纯度: >99.50%

    A prodrug form of dabigatran

  • GC15390 structure
    GC15390Dabigatran etexilate mesylate
    CAS: 872728-81-9
    纯度: >98.00%

    A prodrug form of dabigatran

  • GC16293 structure
    GC16293BIBR 953 (Dabigatran, Pradaxa)
    CAS: 211914-51-1
    纯度: >98.50%

    A thrombin inhibitor

  • GC10140 structure
    GC10140Thrombin Receptor Agonist Peptide
    CAS: 137339-65-2

    A peptide agonist of the α-thrombin receptor

  • GC10398 structure
    GC10398Heparin sodium
    CAS: 9041-08-1
    纯度: >98.00%

    肝素钠作为抗凝剂，属于一类葡聚糖，可与多种蛋白质相互作用，产生多种生物活性。

  • GC11672 structure
    GC11672Argatroban
    CAS: 74863-84-6

    A thrombin inhibitor

  • GC13130 structure
    GC13130Apixaban
    CAS: 503612-47-3
    纯度: >99.50%

    An inhibitor of Factor Xa

  • GC14502 structure
    GC14502AEBSF.HCl
    CAS: 30827-99-7
    纯度: >99.50% / >98.50% / >98.00% / >99.00%

    AEBSF.HCl是丝氨酸蛋白酶广谱的不可逆的抑制剂，可抑制胰凝乳蛋白酶，激肽释放酶，纤溶酶，凝血酶，胰蛋白酶和相关的溶栓酶等。

  • GC17362 structure
    GC17362Metolazone
    CAS: 17560-51-9
    纯度: >99.50%

    A thiazide-like diuretic

  • GC17423 structure
    GC17423TS 155-2
    CAS: 1314486-37-7
    纯度: >95.00%

    An antihypertensive antibiotic

  • GC17726 structure
    GC17726Otamixaban
    CAS: 193153-04-7
    纯度: >98.50%

    Otamixaban(FXV673) 是一种有效的 (Ki = 0.5 nM)、选择性、快速作用、竞争性和可逆的 fXa 抑制剂，可有效抑制游离和凝血酶原结合的 fXa。

  • GC18249 structure
    GC18249NQ301
    CAS: 130089-98-4
    纯度: >98.50%

    A naphthoquinone with diverse biological activities

  • GC19766 structure
    GC19766Heparin sodium salt (MW 15kDa)
    CAS: 9041-08-1
    纯度: >99.50%

    肝素钠盐（MW 15kDa）（Sodium heparin (MW 15kDa)）是肝素的聚合物，分子量为15kDa。

  • GC32554 structure
    GC32554Inogatran (H-314-27)
    CAS: 155415-08-0

    Inogatran (H-314-27) (H-314-27) 是一种合成凝血酶抑制剂，用于治疗和预防动脉和静脉血栓性疾病。

  • GC32567 structure
    GC32567RWJ-445167 (3DP-10017)
    CAS: 226566-43-4

    RWJ-445167 (3DP-10017) (3DP-10017) 是凝血酶和因子 Xa 的双重抑制剂，Ki 分别为 4.0 nM 和 230 nM，具有有效的抗血栓形成活性。

  • GC32619 structure
    GC32619OM-189
    CAS: 55381-18-5

    OM-189是一种人工合成且有选择性的凝血酶抑制剂。

  • GC32639 structure
    GC32639Thrombin inhibitor 1
    CAS: 855998-46-8

    Thrombininhibitor1是一种有效的凝血酶抑制剂(Ki=0.66nM，2xaPTT=0.43μM)。

  • GC32663 structure
    GC32663Desethyl KBT-3022
    CAS: 101001-72-3

    DesethylKBT-3022是新型抗血小板药物KBT-3022的主要活性代谢物。