GlpBio

MMP

MMP(基质金属蛋白酶)

Matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases, generally consisting of a single peptide, a propeptide domain, a catalytic domain with a highly conserved zinc-binding site and a haemopexin-like domain, that catalyze the degradation of all components of the extracellular matrix. Multiple studies have shown that MMPs are overexpressed in malignant tumor and involved in the process of tumor growth, invasion and metastasis. Thus, synthetic and naturally occurring MMP inhibitions have been investigated as anti-cancer agents for the treatment of a variety of cancers, which are divided into three pharmacologic categories, including collagen peptidomimetics and nonpeptidomimetics, tetracycline derivatives and bisphosphonates.

MMP 相关产品(191)

  • GC13750 structure
    GC13750Doxycycline HCl
    CAS: 10592-13-9

    Doxycycline HCl 是一种抗生素，是一种具有口服活性的广谱金属蛋白酶 (MMP) 抑制剂。

  • GC14523 structure
    GC14523GM 6001
    CAS: 142880-36-2
    纯度: >98.00%

    GM 6001 是一种广谱 MMP 抑制剂，可用于癌症和神经退行性疾病的研究，GM 6001对 MMP-1、2、3、8 和 9 的 Ki 值分别为 0.4、0.5、27、0.1和 0.2 nM。

  • GC16530 structure
    GC16530Batimastat (BB-94)
    CAS: 130370-60-4
    纯度: >98.50% / >98.00%

    Batimastat (BB-94)是一种有效的广谱基质金属蛋白酶（MMPs）抑制剂，能够抑制MMP-1，MMP-2，MMP-9，MMP-7和MMP-3，IC 50 值分别为3nM，4nM，4nM，6nM和20nM。

  • GC18144 structure
    GC18144CTS-1027
    CAS: 193022-04-7
    纯度: >98.00%

    An inhibitor of MMPs

  • GC10149 structure
    GC10149cis-ACCP
    CAS: 777075-44-2

    A matrix metalloproteinase inhibitor

  • GC11038 structure
    GC11038MMP-2/MMP-9 Inhibitor I
    CAS: 193807-58-8

    An inhibitor of MMP-2 and MMP-9

  • GC11764 structure
    GC11764MMP Inhibitor II
    CAS: 203915-59-7

    A broad-range inhibitor of MMPs

  • GC12344 structure
    GC12344TAPI-1
    CAS: 163847-77-6

    TAPI-1是一种TACE（肿瘤坏死因子-α转化酶）抑制剂，通过抑制TACE的蛋白水解酶活性，阻断其介导的细胞膜蛋白（两性调节蛋白（AREG））的胞外域脱落过程。

  • GC12838 structure
    GC12838Edaravone
    CAS: 89-25-8
    纯度: >99.50%

    Edaravone是一种经典的自由基清除剂，作为有机小分子可穿越血脑屏障，为脑细胞提供保护。

  • GC13005 structure
    GC13005MMP-2 Inhibitor II
    CAS: 869577-51-5

    A selective MMP-2 inhibitor

  • GC13456 structure
    GC13456Doxycycline hyclate
    CAS: 24390-14-5
    纯度: >98.00%

    Doxycycline hyclate是四环素的衍生物，具有抗炎和抗菌活性。

  • GC15206 structure
    GC15206DC_AC50
    CAS: 497061-48-0
    纯度: >99.00%

    DC_AC50是一种小分子化合物，可抑制铜转运蛋白ATOX-1与CCS，K d 值分别为6.8±1.7μM和8.2±2.7μM。

  • GC15726 structure
    GC15726NNGH
    CAS: 161314-17-6
    纯度: ≥99.00%

    A broad-spectrum MMP inhibitor

  • GC16165 structure
    GC16165T-5224
    CAS: 530141-72-1
    纯度: >98.00%

    T-5224 是一种非肽类小分子 AP-1 抑制剂，特异性抑制 AP-1 与启动子区 AP-1 结合位点的结合，最初开发为抗炎药用于治疗类风湿性关节炎 (RA) 抑制炎症细胞因子和 MMPs 而没有任何副作用。

  • GC16350 structure
    GC16350Actinonin
    CAS: 13434-13-4
    纯度: >99.00%

    Actinonin是一种肽模拟抗生素，能够抑制enkephalin-aminopeptidase、enkephalinase A和 dipeptidylaminopeptidase，IC 50 值分别为0.39μM、5.6μM和1.1μM。

  • GC16577 structure
    GC16577SB-3CT
    CAS: 292605-14-2
    纯度: >99.00%

    A selective inhibitor of MMP-2 and MMP-9

  • GC17242 structure
    GC17242(-)-epigallocatechin
    CAS: 970-74-1
    纯度: >98.00%

    (-)-epigallocatechin是绿茶中的一种主要多酚类化合物，具有抗氧化特性。

  • GC17245 structure
    GC17245MMP-13 Inhibitor
    CAS: 544678-85-5
    纯度: >98.00%

    A selective MMP-13 inhibitor

  • GC17702 structure
    GC17702K-Ras(G12C) inhibitor 9
    CAS: 1469337-91-4

    An allosteric inhibitor of oncogenic K-Ras(G12C)

  • GC17738 structure
    GC17738MMP-2 Inhibitor I
    CAS: 10335-69-0
    纯度: >98.00%

    A selective MMP-2 inhibitor

  • GC18359 structure
    GC183594-Epianhydrochlortetracycline (hydrochloride)
    CAS: 158018-53-2

    An inhibitor of MMP-9

  • GC18510 structure
    GC18510Siccanin
    CAS: 22733-60-4

    An inhibitor of mitochondrial complex II

  • GC18517 structure
    GC18517Diapocynin
    CAS: 29799-22-2

    An inhibitor of NADPH-oxidase

  • GC18608 structure
    GC18608MMP-2/MMP-9 Inhibitor II
    CAS: 193807-60-2

    A dual inhibitor of MMP-2 and MMP-9