GlpBio

MMP

MMP(基质金属蛋白酶)

Matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases, generally consisting of a single peptide, a propeptide domain, a catalytic domain with a highly conserved zinc-binding site and a haemopexin-like domain, that catalyze the degradation of all components of the extracellular matrix. Multiple studies have shown that MMPs are overexpressed in malignant tumor and involved in the process of tumor growth, invasion and metastasis. Thus, synthetic and naturally occurring MMP inhibitions have been investigated as anti-cancer agents for the treatment of a variety of cancers, which are divided into three pharmacologic categories, including collagen peptidomimetics and nonpeptidomimetics, tetracycline derivatives and bisphosphonates.

MMP 相关产品(191)

  • GC18612 structure
    GC18612MMP-9/MMP-13 Inhibitor I
    CAS: 204140-01-2

    An MMP inhibitor

  • GC18616 structure
    GC18616MMP-8 Inhibitor I
    CAS: 236403-25-1
    纯度: >95.00% / >98.00%

    MMP-8 Inhibitor I是一种强效的基质金属蛋白酶-8（MMP-8）抑制剂，但口服生物利用度较低。

  • GC18659 structure
    GC18659Ribavirin 5'-monophosphate (lithium salt)
    CAS: 66983-94-6

    A potent, broad-spectrum antiviral agent

  • GC18706 structure
    GC18706SR 9186
    CAS: 1361414-26-7

    A selective inhibitor of CYP3A4

  • GC18709 structure
    GC18709D-NMMA (acetate)
    CAS: 137694-75-8

    A control compound for studying NOS inhibition

  • GC18791 structure
    GC18791Prostaglandin H1
    CAS: 52589-22-7
    纯度: >95.00%

    The precursor to all 1-series prostaglandins and thromboxanes

  • GC19347 structure
    GC19347TAPI-2
    CAS: 187034-31-7
    纯度: >99.00%

    An inhibitor of TACE and MMPs

  • GC19483 structure
    GC19483MS-PPOH
    CAS: 206052-02-0

    A potent, selective inhibitor of microsomal CYP450 epoxidase activity

  • GC26385 structure
    GC26385CL-82198
    CAS: 307002-71-7
    纯度: >98.00%

    CL-82198 是一个选择性的 MMP-13 抑制剂。

  • GC31734 structure
    GC31734S-methyl-KE-298 (M-2)
    CAS: 143584-75-2

    S-methyl-KE-298 (M-2) 是 KE-298 的活性代谢物。

  • GC31862 structure
    GC31862T-26c
    CAS: 869296-13-9
    纯度: >98.00%

    A selective inhibitor of MMP-13

  • GC31898 structure
    GC31898Histatin 5
    CAS: 115966-68-2

    Histatin 5可抑制基质金属蛋白酶MMP-2和MMP-9的活性，IC 50 值分别为0.57μM和0.25μM。

  • GC32442 structure
    GC32442BR351
    CAS: 960113-85-3

    BR351是可渗透血脑屏障的MMP抑制剂，抑制MMP2，MMP8，MMP9，MMP13的IC50分别为4，2，11，50nM。是正电子发射断层扫描成像活化MMP分子的潜在工具。

  • GC32505 structure
    GC32505XL-784
    CAS: 1224964-36-6
    纯度: >98.00%

    XL-784是MMP的一个选择性抑制剂，其对MMP-1，MMP-3，MMP-8，MMP-9，MMP-13的IC50值分别约为1900，0.81，120，10.8，18，0.56nM。

  • GC32758 structure
    GC32758Isoginkgetin
    CAS: 548-19-6
    纯度: >99.50% / >98.00%

    Isoginkgetin是一种双黄酮类化合物，可抑制胰脂肪酶活性，IC 50 值为2.9µM。

  • GC32792 structure
    GC32792JNJ0966
    CAS: 315705-75-0
    纯度: >99.00%

    An inhibitor of MMP-9 zymogen activation

  • GC32823 structure
    GC32823Incyclinide (CMT-3)
    CAS: 15866-90-7
    纯度: >98.00%

    Incyclinide (CMT-3)是一种非抗生素，由四环素衍生的基质金属蛋白酶（MMP）抑制剂。

  • GC32938 structure
    GC32938S 3304
    CAS: 203640-27-1
    纯度: >99.00%

    S-3304是一个新型的基质金属蛋白酶(MMP)抑制剂,且对MMP-2和MMP-9有特异的抑制活性。

  • GC32951 structure
    GC32951Prinomastat (AG3340)
    CAS: 192329-42-3

    An inhibitor of MMP-2, -3, -9, -13, and -14

  • GC33164 structure
    GC33164PNU-248686A
    CAS: 341498-89-3

    PNU-248686A是一种新型的基质金属蛋白酶(MMP)抑制剂。

  • GC33330 structure
    GC33330Cynaropicrin
    CAS: 35730-78-0
    纯度: >98.00%

    A sesquiterpene lactone

  • GC33365 structure
    GC33365BR351 precursor
    CAS: 960113-89-7

    BR351precursor是BR351的前体。BR351是可渗透血脑屏障的MMP抑制剂，抑制MMP2，MMP8，MMP9，MMP13的IC50分别为4，2，11，50nM。是正电子发射断层扫描成像活化MMP分子的潜在工具。

  • GC33881 structure
    GC33881Ro 31-9790 (GI4747)
    CAS: 145337-55-9

    Ro 31-9790 (GI4747) 是一种合成金属蛋白酶 (MMP) 抑制剂。

  • GC35300 structure
    GC35300Aloin(mixture of A&B)
    CAS: 8015-61-0
    纯度: >95.00%

    An anthroquinone with diverse biological activities