GlpBio

MMP

MMP(基质金属蛋白酶)

Matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases, generally consisting of a single peptide, a propeptide domain, a catalytic domain with a highly conserved zinc-binding site and a haemopexin-like domain, that catalyze the degradation of all components of the extracellular matrix. Multiple studies have shown that MMPs are overexpressed in malignant tumor and involved in the process of tumor growth, invasion and metastasis. Thus, synthetic and naturally occurring MMP inhibitions have been investigated as anti-cancer agents for the treatment of a variety of cancers, which are divided into three pharmacologic categories, including collagen peptidomimetics and nonpeptidomimetics, tetracycline derivatives and bisphosphonates.

MMP 相关产品(191)

  • GC35369 structure
    GC35369Apigenin-7-glucuronide
    CAS: 29741-09-1
    纯度: >98.50%

    Apigenin-7-O-glucuronide (Apigenin-7-glucuronide) is the major flavonoid found in milk thistle. Apigenin 7-o-glucuronide inhibits tumor necrosis factor alpha (TNF-α) and total nitrite release in lipopolysaccharide-activated macrophages.

  • GC35377 structure
    GC35377Apratastat
    CAS: 287405-51-0
    纯度: >99.00%

    Apratastat是一种口服活性、可逆的双重抑制剂，能够抑制肿瘤坏死因子-α转换酶（TACE；IC 50 =81.7ng/mL）和基质金属蛋白酶（MMPs）的活性。

  • GC35470 structure
    GC35470Batimastat sodium salt
    CAS: 130464-84-5

    A potent broad spectrum inhibitor of MMPs

  • GC35754 structure
    GC35754CTTHWGFTLC, CYCLIC
    CAS: 244082-19-7

    CTTHWGFTLC, CYCLIC 是基质金属蛋白酶 MMP-2 和 MMP-9 的环肽抑制剂。

  • GC36137 structure
    GC36137Ginsenoside F4
    CAS: 181225-33-2

    Ginsenoside F4 (GF4)，人参皂甙，从三七或红参中分离。Ginsenoside F4 (GF4) 通过诱导凋亡 (apoptosis) 对人淋巴细胞瘤 JK 细胞具有抑制作用。Ginsenoside F4 (GF4) 抑制 IL-1β 处理的软骨细胞中基质金属蛋白酶 13 (MMP 13) 的表达，阻断兔软骨组织培养中的软骨损坏，具有防止病变组织的软骨胶原基质分解的治疗潜力。

  • GC36230 structure
    GC36230Histatin 5 (TFA)

    Histatin 5 TFA 抑制宿主基质金属蛋白酶 MMP-2 和 MMP-9 活性，IC50s 分别为 0.57 和 0.25 μM。

  • GC36456 structure
    GC36456Licoricidin
    CAS: 30508-27-1

    Licoricidin (LCD) 从甘草 Glycyrrhiza uralensis Fisch 中分离，具有抗癌活性。Licoricidin (LCD) 通过诱导周期停滞，诱导细胞凋亡 (apoptosis) 和自噬 (autophagy)，是一种对抗结直肠癌的潜在化学预防或化学治疗剂。Licoricidin (LCD) 通过抑制肿瘤血管生成和淋巴管生成以及肿瘤组织局部微环境的变化抑制肺转移。Licoricidin (LCD) 通过体外和体内 Akt 和 NF-κB 途径的失活，增强吉西他滨诱导的骨肉瘤 (OS) 细胞的细胞毒性。Licoricidin (LCD) 通过 ROS 清除阻断 UVA 诱导的光老化，限制 MMP-1 的活性，被认为是新的局部应用的抗衰老制剂中的活性成分。

  • GC36489 structure
    GC36489Lucidenic acid C
    CAS: 95311-96-9

    Lucidenic acid C 是从灵芝中分离得到的天然产物，可抑制 PMA 诱导的 MMP-9 活性，对肝癌细胞具有抗侵袭作用。

  • GC36491 structure
    GC36491Lucideric acid A
    CAS: 95311-94-7

    A triterpene with anticancer activity

  • GC36495 structure
    GC36495Luteolin 7-O-glucuronide
    CAS: 29741-10-4
    纯度: >98.00%

    A flavone with diverse biological activities

  • GC36635 structure
    GC36635MMP3 inhibitor 1
    CAS: 312930-75-9

    MMP3 inhibitor 1 是一种有效的高选择性 MMP-3 抑制剂，IC50 为 1 nM。

  • GC38831 structure
    GC38831PF-00356231 hydrochloride
    CAS: 820223-77-6
    纯度: >99.50%

    PF-00356231 hydrochloride 是一种非肽、非锌螯合的基质金属蛋白酶 MMP-12 的配体和抑制剂 (IC50=1.4 μM)。它对 MMP-12 具有特异性并形成 PF-00356231/MMP-12 复合体。PF-00356231 hydrochloride 对 MMP-13、MMP-8、MMP-9、MMP-3 有抑制作用，IC50 分别为 0.00065、1.7、0.98、0.39 μM。

  • GC38837 structure
    GC38837Prinomastat hydrochloride
    CAS: 1435779-45-5
    纯度: >98.00%

    An inhibitor of MMP-2, -3, -9, -13, and -14

  • GC38871 structure
    GC38871XL-784 free base
    CAS: 1356992-21-6

    XL-784 free base 是 MMP 的一个选择性抑制剂，其对 MMP-1，MMP-3，MMP-8，MMP-9，MMP-13 的 IC50 值分别约为 1900，0.81，120，10.8，18，0.56 nM。

  • GC38929 structure
    GC38929MMP-9-IN-1
    CAS: 502887-71-0
    纯度: >98.00%

    MMP-9-IN-1是基质金属蛋白酶-9（MMP-9）的特异性抑制剂。它通过选择性靶向MMP-9的血浆铜蓝蛋白（PEX）结构域发挥作用，Kd值为2.1μM。

  • GC39095 structure
    GC39095Isoliquiritin apioside
    CAS: 120926-46-7
    纯度: >99.50%

    Isoliquiritin apioside (ISLA, ILA), a component isolated from Glycyrrhizae radix rhizome (GR), significantly decreases PMA-induced increases in matrix metalloproteinase (MMP) activities and suppresses PMA-induced activation of mitogen-activated protein kinase (MAPK) and NF-κB. Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and ECs, with no cytotoxicity.

  • GC39134 structure
    GC39134Isofraxidin
    CAS: 486-21-5
    纯度: >98.00%

    Isofraxidin (6,8-Dimethoxyumbelliferone), a bioactive coumarin compound isolated from the functional foods Siberian ginseng and Apium graveolens, is an anti-bacterial, anti-oxidant, and anti-inflammatory agent.

  • GC39640 structure
    GC39640GPLGIAGQ TFA
    纯度: >99.50% / >98.00%

    GPLGIAGQ TFA 是一种 MMP2 可切割的多肽，在脂质体和胶束纳米载体中都被用作刺激敏感的连接物，用于 MMP2 触发的肿瘤靶向治疗。GPLGIAGQ TFA可用于合成光动力治疗 (PDT) 中独特的 MMP2 靶向光敏剂。

  • GC40220 structure
    GC40220Pravastatin-d3 (sodium salt)
    CAS: 1329836-90-9
    纯度: >99.00%

    An internal standard for the quantification of pravastatin

  • GC40221 structure
    GC40221Ritonavir-d6
    CAS: 1217720-20-1
    纯度: >99.00%

    An internal standard for the quantification of ritonavir

  • GC40229 structure
    GC40229(±)-Warfarin-d5
    CAS: 75472-93-4
    纯度: >99.00%

    An internal standard for the quantification of warfarin

  • GC40234 structure
    GC40234Ramipril-d5
    CAS: 1132661-86-9
    纯度: >99.00%

    An internal standard for the quantification of ramipril

  • GC40538 structure
    GC40538Decylubiquinone
    CAS: 55486-00-5
    纯度: >98.00%

    An analog of ubiquinone (coenzyme Q 10 )

  • GC40624 structure
    GC40624MMP-3 Inhibitor VIII
    CAS: 208663-26-7
    纯度: >95.00%

    A selective inhibitor of MMP-3