MMP
MMP(基质金属蛋白酶)
Matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases, generally consisting of a single peptide, a propeptide domain, a catalytic domain with a highly conserved zinc-binding site and a haemopexin-like domain, that catalyze the degradation of all components of the extracellular matrix. Multiple studies have shown that MMPs are overexpressed in malignant tumor and involved in the process of tumor growth, invasion and metastasis. Thus, synthetic and naturally occurring MMP inhibitions have been investigated as anti-cancer agents for the treatment of a variety of cancers, which are divided into three pharmacologic categories, including collagen peptidomimetics and nonpeptidomimetics, tetracycline derivatives and bisphosphonates.
MMP 相关产品(191)
- GN10494Astragaloside IVCAS: 84687-43-4纯度: >98.00%
Astragaloside IV是黄芪中提取的一种有效成分，可减轻心肌缺血/再灌注损伤，抑制HAdV-3复制，减少HAdV-3诱导的细胞凋亡 。
- GN10578Polygalacic acidCAS: 22338-71-2纯度: >98.50%
A triterpenoid saponin with antioxidant and neuroprotective activities
- GN10783(R) Ginsenoside Rh2CAS: 112246-15-8纯度: >98.00%
A steroid glycoside with diverse biological activities
- GN10810CordycepinCAS: 73-03-0纯度: >99.00% / >97.50% / >98.00%
Cordycepin（3’-deoxyadenosine; 虫草素）是一种核苷类似物，抑制聚腺苷酸化。
- GP26167MMP2 Mouse
MMP2 Mouse produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 644 amino acids (30-662 aa) and having a molecular mass of 72
- GP26168MMP9 Mouse
MMP9 Mouse produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 711 amino acids (20-730 a
- GP10057Amyloid β-Peptide (10-20) (human)CAS: 152286-31-2
Amyloid β-Peptide (10-20) (human) 是 Amyloid-β 的片段；肽，可用于神经系统疾病的研究。
- GC14578GI 254023XCAS: 260264-93-5纯度: >98.00%
GI 254023X是一种选择性抑制剂，针对MMP9（Matrix Metalloproteinase 9）的IC 50 值为5.3nM，GI 254023X对ADAM10（A Disintegrin and Metalloproteinase 10）的选择性是ADAM17的100倍，IC 50 值为2.5nM。GI 254023X主要用于免疫学、炎症和神经退行性疾病的研究。
- GC13707WAY 170523CAS: 307002-73-9
WAY 170523 是一种有效的选择性 MMP-13（基质金属蛋白酶 13）抑制剂，IC50 为 17 nM。 WAY 170523 可以直接减弱 ERK1/2 磷酸化。 WAY 170523抑制PC-3细胞的侵袭，可用于前列腺癌研究。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GN10359 | Stigmasterol | 83-48-7 | >98.00% | |
Stigmasterol豆甾醇是一种天然的甾醇。Stigmasterol具有显著的抗关节炎和抗炎作用。 | ||||
| GN10360 | Morroniside | 25406-64-8 | >98.00% | |
A mixture of iridoid glucosides | ||||
| GN10473 | Ginkgolide C | 15291-76-6 | >98.00% | |
A PAF receptor antagonist | ||||
| GN10494 | Astragaloside IV | 84687-43-4 | >98.00% | |
Astragaloside IV是黄芪中提取的一种有效成分，可减轻心肌缺血/再灌注损伤，抑制HAdV-3复制，减少HAdV-3诱导的细胞凋亡 。 | ||||
| GN10578 | Polygalacic acid | 22338-71-2 | >98.50% | |
A triterpenoid saponin with antioxidant and neuroprotective activities | ||||
| GN10783 | (R) Ginsenoside Rh2 | 112246-15-8 | >98.00% | |
A steroid glycoside with diverse biological activities | ||||
| GN10810 | Cordycepin | 73-03-0 | >99.00% / >97.50% / >98.00% | |
Cordycepin（3’-deoxyadenosine; 虫草素）是一种核苷类似物，抑制聚腺苷酸化。 | ||||
| GP26167 | MMP2 Mouse | - | - | |
MMP2 Mouse produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 644 amino acids (30-662 aa) and having a molecular mass of 72 | ||||
| GP26168 | MMP9 Mouse | - | - | |
MMP9 Mouse produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 711 amino acids (20-730 a | ||||
| GC14210 | NSC 405020 | 7497-07-6 | >99.50% | |
NSC 405020是一种特异性膜基质金属蛋白酶（MT1-MMP）小分子抑制剂。 | ||||
| GP10057 | Amyloid β-Peptide (10-20) (human) | 152286-31-2 | - | |
Amyloid β-Peptide (10-20) (human) 是 Amyloid-β 的片段；肽，可用于神经系统疾病的研究。 | ||||
| GC14578 | GI 254023X | 260264-93-5 | >98.00% | |
GI 254023X是一种选择性抑制剂，针对MMP9（Matrix Metalloproteinase 9）的IC 50 值为5.3nM，GI 254023X对ADAM10（A Disintegrin and Metalloproteinase 10）的选择性是ADAM17的100倍，IC 50 值为2.5nM。GI 254023X主要用于免疫学、炎症和神经退行性疾病的研究。 | ||||
| GC13487 | ARP 100 | 704888-90-4 | >99.00% / >98.00% | |
A selective inhibitor of MMP-2 | ||||
| GC15954 | UK 356618 | 230961-08-7 | >98.50% | |
An inhibitor of MMP-3 | ||||
| GC12465 | ARP 101 | 849773-63-3 | >99.00% | |
ARP 101 是一种有效的选择性抑制剂基质金属蛋白酶 2 (MMP-2)。 ARP 101 在癌细胞中诱导自噬相关的细胞死亡。 ARP 101 可有效诱导自噬体的形成和 LC3I 转化为 LC3II。 | ||||
| GC14099 | Marimastat | 154039-60-8 | >98.00% | |
Marimastat是一种广谱的，具有口服活性的基质金属蛋白酶（MMP）抑制剂，IC 50 值为3~13nM。 | ||||
| GC15952 | CL 82198 hydrochloride | 1188890-36-9 | >98.00% | |
An inhibitor of MMP-13 | ||||
| GC12157 | CP 471474 | 210755-45-6 | - | |
A broad-spectrum MMP inhibitor | ||||
| GC15005 | ONO 4817 | 223472-31-9 | - | |
An inhibitor of MMP-2 and MMP-9 | ||||
| GC12111 | PD 166793 | 199850-67-4 | >99.00% | |
An broad-spectrum MMP inhibitor | ||||
| GC10805 | Ro 32-3555 | 190648-49-8 | - | |
Ro 32-3555 是一种有效的、竞争性的人类胶原酶 1、2 和 3 抑制剂，Kis 分别为 3.0、4.4 和 3.4 nM。 | ||||
| GC16579 | UK 370106 | 230961-21-4 | - | |
UK 370106 是一种有效且高度选择性的 MMP-3（IC50 为 23 nM）和 MMP-12（IC50 为 42 nM）抑制剂，其效力比 MMP-1、MMP-2、MMP-9 和 MMP 高 1200 倍以上-14，大约是 MMP-13 和 MMP-8 的 100 倍。 | ||||
| GC13707 | WAY 170523 | 307002-73-9 | - | |
WAY 170523 是一种有效的选择性 MMP-13（基质金属蛋白酶 13）抑制剂，IC50 为 17 nM。 WAY 170523 可以直接减弱 ERK1/2 磷酸化。 WAY 170523抑制PC-3细胞的侵袭，可用于前列腺癌研究。 | ||||