GlpBio

Stigmasterol

目录号: GN10359纯度: >98.00%同义词: 豆甾醇; Stigmasterin
COASDSData SheetHPLC

Stigmasterol豆甾醇是一种天然的甾醇。Stigmasterol具有显著的抗关节炎和抗炎作用。

Stigmasterol
Cas No.: 83-48-7
规格价格库存数量操作
20mg¥330.00现货
1
10mM (in 1mL Ethanol)¥330.00现货
1
电话: 400-920-5774Email: sales@glpbio.cn

文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
  • Nature cover
    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
  • Cell Research cover
    Cell Research
    34, 683–706 (2024)
  • Cell Research cover
    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

Stigmasterol is a naturally available sterol. stigmasterol has significant anti-arthritis and anti-inflammatory effects[1-3].

Stigmasterol(0-100μM;14 h) inhibited glutamate-induced neuronal cell death in the HT-22 cells[4].Stigmasterol(0-20μM;4 h) alleviated Aβ42 oligomers induced inflammatory response in BV2 cells[5].

Stigmasterol(400 mg/kg/d; i. g; 10 days) treatment attenuates DSS-induced colitis in mice[6].Stigmasterol(100 mg/kg;i.p;21-27days) inhibited inflammation and oxidative stress in a mouse model of asthma by NK1-R[7].In the hippocampus of APP/PS1 mice, stigmasterol suppressed the microglia activation[8], and stigmasterol also decreased the TNF-α levels in the cortex of Swiss albino mice[9].

References:

[1]. Antwi AO, Obiri DD, et,al. Stigmasterol Alleviates Cutaneous Allergic Responses in Rodents. Biomed Res Int. 2018 Jul 24;2018:3984068. doi: 10.1155/2018/3984068. PMID: 30140696; PMCID: PMC6081592.

[2]. Gabay O, Sanchez C, et,al. Stigmasterol: a phytosterol with potential anti-osteoarthritic properties. Osteoarthritis Cartilage. 2010 Jan;18(1):106-16. doi: 10.1016/j.joca.2009.08.019. Epub 2009 Sep 15. PMID: 19786147.

[3]. Chen WP, Yu C, et,al. Stigmasterol blocks cartilage degradation in rabbit model of osteoarthritis. Acta Biochim Pol. 2012;59(4):537-41. Epub 2012 Oct 16. PMID: 23074702.

[4]. Mongkolpobsin K, Sillapachaiyaporn C, et,al. Stigmasterol isolated from Azadirachta indica flowers attenuated glutamate-induced neurotoxicity via downregulation of the Cdk5/p35/p25 signaling pathway in the HT-22 cells. Phytomedicine. 2023 May;113:154728. doi: 10.1016/j.phymed.2023.154728. Epub 2023 Feb 24. PMID: 36898255.

[5]. Jie F, Yang X, et,al. Stigmasterol attenuates inflammatory response of microglia via NF-κB and NLRP3 signaling by AMPK activation. Biomed Pharmacother. 2022 Sep;153:113317. doi: 10.1016/j.biopha.2022.113317. Epub 2022 Jun 27. PMID: 35772378.

[6]. Wen S, He L, et,al. Stigmasterol Restores the Balance of Treg/Th17 Cells by Activating the Butyrate-PPARγ Axis in Colitis. Front Immunol. 2021 Oct 6;12:741934. doi: 10.3389/fimmu.2021.741934. PMID: 34691046; PMCID: PMC8526899.

[7]. Zhang J, Zhang C, et,al. Stigmasterol alleviates allergic airway inflammation and airway hyperresponsiveness in asthma mice through inhibiting substance-P receptor. Pharm Biol. 2023 Dec;61(1):449-458. doi: 10.1080/13880209.2023.2173252. PMID: 36788676; PMCID: PMC9930798.
[8]. Koivisto H, Grimm MO, et,al. Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease independent of brain amyloid deposition. J Nutr Biochem. 2014 Feb;25(2):157-69. doi: 10.1016/j.jnutbio.2013.09.015. Epub 2013 Nov 6. PMID: 24445040.
 
[9]. Yadav M, Parle M, et,al. Protective effects of stigmasterol against ketamine-induced psychotic symptoms: Possible behavioral, biochemical and histopathological changes in mice. Pharmacol Rep. 2018 Jun;70(3):591-599. doi: 10.1016/j.pharep.2018.01.001. Epub 2018 Jan 11. PMID: 29679883.

Stigmasterol豆甾醇是一种天然的甾醇。Stigmasterol具有显著的抗关节炎和抗炎作用[1-3]。

Stigmasterol (0-100μM;14 h)抑制谷氨酸诱导的HT-22细胞死亡[4]。Stigmasterol (0-20μM;4 h)可减轻Aβ42低聚物诱导的BV2细胞炎症反应[5]。

Stigmasterol (400 mg/kg/d; i. g; 10 days) 治疗可减轻DSS诱导的小鼠结肠炎[6]。Stigmasterol (100 mg/kg;i.p;21-27days)通过NK1-R抑制小鼠哮喘模型的炎症和氧化应激[7]。在APP/PS1小鼠海马体中，Stigmasterol抑制了小胶质细胞的激活，并降低了Swiss albino小鼠皮质中TNF-α的水平[8-9]。

实验参考方法 Experimental Reference Method

Cell experiment [1]:

Cell lines

Murine BV2 microglia cells

Preparation method

Cells were treated with Aβ42 oligomers for 24 h, followed by treatment of stigmasterol (dissolved in ethanol) for 4 h.

Reaction Conditions

0-20μM;4 h

Applications

Stigmasterol alleviated Aβ42 oligomers induced inflammatory response in BV2 cells.

Animal experiment [2]:

Animal models

Male C57bl/6J mice (ovalbumin (OVA)-induced asthma model)

Preparation method

Asthma mice were divided into OVA group, Stigmasterol group, and Stigmasterol + rh-NK1R protein (Stig-NK1R) group. In corresponding groups, 100 mg/kg stigmasterol, and 100 μg rh-NK1R were intraperitoneally injected into mice on days 21, 22, 23, 24, 25, 26, 27 before the challenge with OVA.

Dosage form

100 mg/kg;i.p;21-27days

Applications

Stigmasterol inhibited inflammation and oxidative stress in a mouse model of asthma by NK1-R.

References:

[1]. Jie F, Yang X,et,al. Stigmasterol attenuates inflammatory response of microglia via NF-κB and NLRP3 signaling by AMPK activation. Biomed Pharmacother. 2022 Sep;153:113317. doi: 10.1016/j.biopha.2022.113317. Epub 2022 Jun 27. PMID: 35772378.

[2]. Zhang J, Zhang C, et,al. Stigmasterol alleviates allergic airway inflammation and airway hyperresponsiveness in asthma mice through inhibiting substance-P receptor. Pharm Biol. 2023 Dec;61(1):449-458. doi: 10.1080/13880209.2023.2173252. PMID: 36788676; PMCID: PMC9930798.

产品文档 Product Documents

Purity:>98.00%
COASDSData SheetHPLC

化学性质Chemical Properties

CAS 号
83-48-7
同义词
豆甾醇; Stigmasterin
化学名
(3S,8S,9S,10R,13R,14S,17R)-17-[(E,2R,5S)-5-ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
SMILES
CCC(C=CC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)C(C)C
分子式
C29H48O
分子量
412.69 g/mol
溶解性
5mg/mL in Ethanol (Need ultrasonic)
保存条件
Store at 2-8°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol