MMP
MMP(基质金属蛋白酶)
Matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases, generally consisting of a single peptide, a propeptide domain, a catalytic domain with a highly conserved zinc-binding site and a haemopexin-like domain, that catalyze the degradation of all components of the extracellular matrix. Multiple studies have shown that MMPs are overexpressed in malignant tumor and involved in the process of tumor growth, invasion and metastasis. Thus, synthetic and naturally occurring MMP inhibitions have been investigated as anti-cancer agents for the treatment of a variety of cancers, which are divided into three pharmacologic categories, including collagen peptidomimetics and nonpeptidomimetics, tetracycline derivatives and bisphosphonates.
MMP 相关产品(191)
- GC41552ω-3 Arachidonic AcidCAS: 24880-40-8纯度: >98.00%
A rare, natural 20:4 ω-3 polyunsaturated fatty acid
- GC41776Triolein (1,2,3-Trioleoyl-rac-glycerol)CAS: 122-32-7纯度: >80.00% / >95.00% / >99.00%
Triolein (1,2,3-Trioleoyl-rac-glycerol)是一种甘油三酯，被用于研究脂质代谢相关过程。Triolein可作为模型底物来探究脂肪在体内的消化、吸收以及转运等情况。
- GC43114Caffeic Acid-13C3CAS: 1185245-82-2纯度: >95.00%
An internal standard for the quantification of caffeic acid
- GC43912IsoapoptolidinCAS: 476647-30-0纯度: >90.00%
Isoapoptolidin is a stable derivative of apoptolidin that demonstrates 10-fold reduced F1FO-ATP synthase inhibitory activity compared to apoptolidin (IC50s = 17 and 0.7 μM, respectively).
- GC44186Metoclopramide (hydrochloride)CAS: 7232-21-5纯度: >98.00%
An orally bioavailable 5-HT 3 and D 2 receptor antagonist
- GC44306N-acetyl-S-geranylgeranyl-L-CysteineCAS: 139332-94-8纯度: >95.00%
A synthetic substrate for the SAM-dependent methyltransferase
- GC44441N-Oleoyl LeucineCAS: 136560-76-4纯度: >98.00%
An N-acyl amide involved in mitochondrial uncoupling
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC41251 | Pirlindole | 60762-57-4 | >98.00% | |
A selective and reversible MAO-A inhibitor | ||||
| GC41258 | Spiroxamine | 118134-30-8 | >95.00% | |
A fungicide | ||||
| GC41552 | ω-3 Arachidonic Acid | 24880-40-8 | >98.00% | |
A rare, natural 20:4 ω-3 polyunsaturated fatty acid | ||||
| GC41642 | 9(E),11(E),13(E)-Octadecatrienoic Acid | 544-73-0 | >97.00% | |
A polyunsaturated fatty acid | ||||
| GC41776 | Triolein (1,2,3-Trioleoyl-rac-glycerol) | 122-32-7 | >80.00% / >95.00% / >99.00% | |
Triolein (1,2,3-Trioleoyl-rac-glycerol)是一种甘油三酯，被用于研究脂质代谢相关过程。Triolein可作为模型底物来探究脂肪在体内的消化、吸收以及转运等情况。 | ||||
| GC42665 | AAF-CMK (trifluoroacetate salt) | 184901-82-4 | >95.00% | |
An inhibitor of TPPII | ||||
| GC42873 | Auraptene | 495-02-3 | >99.50% | |
A coumarin derivative with anti-inflammatory and chemopreventative activity | ||||
| GC43050 | C18 L-erythro Ceramide (d18:1/18:0) | 252039-52-4 | >98.00% | |
A naturally occurring ceramide | ||||
| GC43051 | C18 L-threo Ceramide (d18:1/18:0) | 95037-06-2 | >98.00% | |
A synthetic ceramide | ||||
| GC43114 | Caffeic Acid-13C3 | 1185245-82-2 | >95.00% | |
An internal standard for the quantification of caffeic acid | ||||
| GC43146 | Caspase-9 Inhibitor III (trifluoroacetate salt) | - | >95.00% | |
A caspase-9 inhibitor | ||||
| GC43188 | CAY10680 | 1439488-21-7 | >98.00% | |
A dual inhibitor of monoamine oxidase B and adenosine A 2A receptors | ||||
| GC43725 | Gallocyanine | 1562-85-2 | >95.00% | |
A Dkk1 inhibitor | ||||
| GC43780 | GM 1489 | 171347-75-4 | >98.00% | |
An MMP inhibitor | ||||
| GC43912 | Isoapoptolidin | 476647-30-0 | >90.00% | |
Isoapoptolidin is a stable derivative of apoptolidin that demonstrates 10-fold reduced F1FO-ATP synthase inhibitory activity compared to apoptolidin (IC50s = 17 and 0.7 μM, respectively). | ||||
| GC44186 | Metoclopramide (hydrochloride) | 7232-21-5 | >98.00% | |
An orally bioavailable 5-HT 3 and D 2 receptor antagonist | ||||
| GC44214 | ML-162 | 1035072-16-2 | >99.50% | |
ML-162是一种可抑制谷胱甘肽过氧化物酶4（GPX4）的小分子化合物，IC 50 值为1.42μM。 | ||||
| GC44236 | MMP-2/MMP-9 Inhibitor III (trifluoroacetate salt) | - | >95.00% | |
An inhibitor of MMP-2 and MMP-9 | ||||
| GC44237 | MMP-9 Inhibitor I | 206549-55-5 | >95.00% | |
An inhibitor of MMP-9 | ||||
| GC44306 | N-acetyl-S-geranylgeranyl-L-Cysteine | 139332-94-8 | >95.00% | |
A synthetic substrate for the SAM-dependent methyltransferase | ||||
| GC44341 | ND-336 | 1807453-83-3 | >95.00% | |
A selective inhibitor of MMP-2, -9, and -14 | ||||
| GC44431 | nNOS Inhibitor I | 357965-99-2 | >95.00% | |
A selective inhibitor of nNOS | ||||
| GC44441 | N-Oleoyl Leucine | 136560-76-4 | >98.00% | |
An N-acyl amide involved in mitochondrial uncoupling | ||||
| GC44891 | Simeprevir (sodium salt) | 1241946-89-3 | >98.00% | |
A potent NS3/4A protease inhibitor | ||||