GlpBio

MMP-2/MMP-9 Inhibitor III (trifluoroacetate salt)

目录号: GC44236纯度: >95.00%同义词: Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Inhibitor III
An inhibitor of MMP-2 and MMP-9
MMP-2/MMP-9 Inhibitor III (trifluoroacetate salt)
规格价格库存数量操作
1mg¥3,296.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
  • Nature cover
    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
  • Cell Research cover
    Cell Research
    34, 683–706 (2024)
  • Cell Research cover
    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

MMP-2/MMP-9 inhibitor III is a cyclic peptide inhibitor of matrix metalloproteinase-2 (MMP-2) and MMP-9 (IC50s = 10-20 μM for both). It is selective for MMP-2 and MMP-9 over MT1-MMP, MMP-8, and MMP-13 as well as the serine proteases trypsin-2, neutrophil elastase, and cathepsin G when used at a concentration of 500 μM. MMP-2/MMP-9 inhibitor III reduces migration of HT1080 fibrosarcoma, C8161 melanoma, SK-OV-3 ovarian carcinoma, and KS1767 Kaposi's sarcoma cells in vitro. Pretreatment with MMP-2/MMP-9 inhibitor III delays tumor formation in an MDA-MB-435 mouse xenograft model. MMP-2/MMP-9 inhibitor III (100-200 μg per animal) also prevents growth of established tumors in MDA-MB-435 and KS1767 mouse xenograft models.

产品文档 Product Documents

Purity:>95.00%Appearance:A solid

化学性质Chemical Properties

同义词
Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Inhibitor III
SMILES
O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@]([C@H](O)C)([H])C(N[C@@H](CC(C)C)C2=O)=O)=O)CNC([C@H](CC3=CNC4=C3C=CC=C4)NC([C@H](CC5=CNC=N5)NC([C@@]([C@H](O)C)([H])NC([C@@]([C@H](O)C)([H])NC([C@@H](N)CSSC[C@@H](C(O)=O)N2)=O)=O)=O)=O)=O.FC(F)(C(O)=O)F
分子式
C52H71N13O14S2•XCF3COOH
分子量
1166.3 g/mol
溶解性
Water: 1 mg/ml
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol