PTP1B-IN-2

目录号: GC31324纯度: >99.50%同义词: Protein Tyrosine Phosphatase 1B Inhibitor 2

A PTP1B inhibitor

Cas No.: 1919853-46-5

规格	价格	库存	数量
1mg	¥477.00	现货	1
5mg	¥840.00	现货	1
10mg	¥1,190.00	现货	1
25mg	¥2,380.00	现货	1
50mg	¥3,500.00	现货	1
10mM (in 1mL DMSO)	¥1,260.00	现货	1

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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例

Nature
641, 529–536 (2025)
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628, 630–638 (2024)
Nature
632, 686–694 (2024)
Nature
618, 1017–1023 (2023)
Nature
610, 366–372 (2022)
Cell
187(9):2288-2304 (2024)
Cell
183(7):1867-1883 (2020)
Science
388(6745) (2025)
Science
387(6739) (2025)
Science
387(6734) (2025)
Cell Research
35, 97–116 (2025)
Cell Research
34, 683–706 (2024)
Cell Research
33, 273–287 (2023)
Cell Research
33, 546–561 (2023)
Cell Research
33, 904–922 (2023)
Cell Research
31, 1291–1307 (2021)

产品描述 Description

PTP1B-IN-2 is an inhibitor of protein tyrosine phosphatase 1B (PTP1B; IC₅₀ = 50 nM).¹ It is selective for PTP1B over T cell protein tyrosine phosphatase (TCPTP), Src homology region 2 domain-containing phosphatase 1 (SHP-1), SHP-2, and leukocyte common antigen-related (LAR) phosphatase (IC₅₀s = 760, 2,450, 2,160, and 12,610 nM, respectively). PTP1B-IN-2 (5-20 ?M) enhances insulin-induced glucose uptake in L6 myotubes.

1.Liu, P., Du, Y., Song, L., et al.Discovery of novel, high potent, ABC type PTP1B inhibitors with TCPTP selectivity and cellular activityEur. J. Med. Chem.11827-33(2016)

实验参考方法 Experimental Reference Method

Kinase experiment:

PTP1B-IN-2 is predispensed in 96-well microplates as 1.0 µL aliquots per well in 100% DMSO. The PTP1B enzymatic assay is carried out in a total volume of 100 µL per well in assay plates with 15 nM recombinant PTP1B protein, 2 mM p-nitrophenylphosphonic acid (pNPP), 1 mM dithiothreitol and 1 mM EDTA (pH 6.5). After 30 min incubation at 37oC, the reaction is terminated by addition of 2.5 M NaOH. The amount of hydrolysis product, pNP, is monitored by detection of the absorbance at 405 nm[1].

References:

[1]. Liu P, et al. Discovery of novel, high potent, ABC type PTP1B inhibitors with TCPTP selectivity and cellular activity. Eur J Med Chem. 2016 Aug 8;118:27-33.

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号

1919853-46-5

同义词

Protein Tyrosine Phosphatase 1B Inhibitor 2

SMILES

O=S(N(C1=CC(C(OC)=O)=C(OCC2=CC=C(C)C=C2)C=C1)CC3=CC=C(N(S(C)(=O)=O)CC(OC)=O)C=C3)(CC4=CC=CC=C4)=O

分子式

C₃₄H₃₆N₂O₉S₂

分子量

680.79 g/mol

溶解性

DMSO : ≥ 100 mg/mL (146.89 mM)

保存条件

Store at -20°C

General tips

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。

Shipping Condition

评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

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